1. 2018
  2. Published

    Valproic acid and its congener propylisopropylacetic acid reduced the amount of soluble amyloid-β oligomers released from 7PA2 cells

    Williams, R. & Bate, C. 1 Jan 2018 In : Neuropharmacology. 128, p. 54-62 9 p.

    Research output: Contribution to journalArticle

  3. 2017
  4. E-pub ahead of print

    Curcumin and derivatives function through protein phosphatase 2A and presenilin orthologues in Dictyostelium discoideum

    Cocorocchio, M., A, B., Stewart, B. L., Harwood, A. J., Thompson, C., Andrews, P. & Williams, R. 28 Dec 2017 In : Disease Models and Mechanisms.

    Research output: Contribution to journalArticle

  5. Forthcoming
  6. Forthcoming
  7. E-pub ahead of print

    Induction of the cell survival kinase Sgk1: a possible novel mechanism for α-phenyl-N-tertbutyl nitrone (PBN) in experimental stroke

    McCaig, C., Ataliotis, P., Shtaya, A., Omar, A. S., Green, A. R., Kind, C. N., Pereira, A. C., Naray-Fejes-Toth, A., Fejes-Toth, G., Yanez, R., Murray, J. T. & Hainsworth, A. H. 20 Dec 2017 In : Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

    Research output: Contribution to journalArticle

  8. Published

    Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy

    Moore, M. , Popplewell, L. , Dickson, G. & 18 others Benedetti, S., Uno, N., Hoshiya, H., Ragazzi, M., Ferrari, G., Kazuki, Y., Moyle, L. A., Tonlorenzi, R., Lombardo, A., Chaouch, S., Mouly, V., Kazuki, K., Katoh, M., Naldini, L., Messina, G., Oshimura, M., Cossu, G. & Tedesco, F. S. 14 Dec 2017 In : EMBO Reports.

    Research output: Contribution to journalArticle

  9. Forthcoming

    Mechanisms of action for the medium-chain triglyceride ketogenic diet in neurological and metabolic disorders

    Augustin, K., Khabbush, A., Williams, S., Eaton, S., Orford, M., Cross, H., Heales, S., Walker, M. & Williams, R. 20 Nov 2017 In : Lancet Neurology.

    Research output: Contribution to journalLiterature review

  10. Forthcoming

    Biological Containment of Genetically Modified Bacillus subtilis

    Hosseini, S., Curilovs, A. & Cutting, S. 15 Nov 2017 In : Applied and environmental microbiology. 84, 3, 10.1128/AEM.02334-17

    Research output: Contribution to journalArticle

  11. Forthcoming

    Evaluation of anticoagulation status for atrial fibrillation on early ischaemic stroke outcomes: a registry-based, prospective cohort study of acute stroke care in Surrey, United Kingdom

    Han, T., Fry, C., Fluck, D., Affley, B., Gulli, G., Barrett, C., Kakar, P., Patel, T. & Sharma, P. 1 Nov 2017 In : BMJ Open.

    Research output: Contribution to journalArticle

  12. Published

    Impacts of undetected and inadequately treated hypertension on incident stroke in China

    Han, T., Wang, H., Wei, L., Pan, Y., Ying Ma, Y. M., Wang, Y., Wang, J., Hu, Z., Sharma, P. & Chen, R. 8 Oct 2017 In : BMJ Open. 7, 10, p. 1-10 10 p.

    Research output: Contribution to journalArticle

  13. Published

    Beneficial effects of carotenoid-producing cells of Bacillus indicus HU16 in a rat model of diet-induced metabolic syndrome

    Crescenzo, R., Mazzoli, A., Cancelliere, R., Bucci, A., Naclerio, G., Baccigalupi, L., Cutting, S., Ricca, E. & Iossa, S. 3 Oct 2017 In : Beneficial microbes. 8, 5, p. 823 - 831 8 p.

    Research output: Contribution to journalArticle

  14. Published

    Design and Rationale for Examining Neuroimaging Genetics in Ischemic Stroke: the MRI- GENIE Study

    Sharma, P. & 40 others Giese, A. K., Schirmer, M. D., Donahue, K. L., Cloonan, L., Irie, R., Winzeck, S., Bouts, M. J. R. J., McIntosh, E. C., Mocking, S. J., Dalca, A. V., Sridharan, R., Xu, H., Frid, P., Giralt-Steinhauer, E., Holmegaard, L., Roquer, J., Wasselius, J., Cole, J. W., McArdle, P. F., Broderick, J. P., Jimenez-Conde, . J., Jern, C., Kissela, B. M., Kleindorfer, D. O., Lemmens, R., Lindgren, A., Meschia, J. F., Rundek, T., Sacco , R. L., Schmidt, R., Slowik, A., Thijs, V., Woo, D., Worrall, B. B., Kittner, S. J., Mitchell, B. D., Rosand, J., Golland, P., Wu, O. & Rost, N. S. 1 Oct 2017 In : Neurology: Genetics. 3, 5

    Research output: Contribution to journalArticle

  15. Published

    Nonintegrating Gene Therapy Vectors

    Athanasopoulos, T., Munye, M. M. & Yáñez-Muñoz, R. J. 1 Oct 2017 In : Hematology/Oncology Clinics of North America. 31, 5, p. 753-770 18 p.

    Research output: Contribution to journalArticle

  16. Published

    Synapsin I phosphorylation is dysregulated by beta-amyloid oligomers and restored by valproic acid

    Marsh, J., Bagol, S. H., Williams, R., Dickson, J. & Alifragis, P. 1 Oct 2017 In : Neurobiology of Disease.

    Research output: Contribution to journalArticle

  17. Published

    Inducible Expression of Spo0A as a Universal Tool for Studying Sporulation in Clostridium difficile

    Dembek, M., Willing, S., Huynh, H., Hosseini, S., Salgado, P. & Cutting, S. 21 Sep 2017 In : Frontiers in microbiology.

    Research output: Contribution to journalArticle

  18. Published

    Dysfunctional transcripts are formed by alternative polyadenylation in OPMD

    Raz, V., Dickson, J. & 't Hoen, P. A. C. 5 Sep 2017 In : Oncotarget. 8, 43, p. 73516-73528 13 p.

    Research output: Contribution to journalArticle

  19. Published
  20. Published

    Protein Conjugation to Nanoparticles by Designer Affinity Tags

    Ma, W., Aboagye-Mensaha, D., Soloviev, M., Davletov, B. & Ferrari, E. 1 Sep 2017 In : Materials Today: Proceedings. 4, p. 6923–6929 7 p.

    Research output: Contribution to journalArticle

  21. Published
  22. E-pub ahead of print

    BCAP is a centriolar satellite protein and inhibitor of ciliogenesis

    De Saram, P., Iqbal, A., Murdoch, J. & Wilkinson, C. 3 Aug 2017 In : Journal of Cell Science. p. 1-43 43 p.

    Research output: Contribution to journalArticle

  23. Published

    Therapeutic strategies for spinal muscular atrophy: SMN and beyond

    Bowerman, M., Becker, C. G., Yáñez-Muñoz, R. J., Ning, K., Wood, M. J. A., Gillingwater, T. H., Talbot, K. & UK SMA Research Consortium 1 Aug 2017 In : Disease Models and Mechanisms. 10, 8, p. 943-954 12 p.

    Research output: Contribution to journalArticle

  24. Published

    Monitoring risk factors of cardiovascular disease in cancer survivors

    Kapoor, A., Pakash, V., Sekhar, M., Greenfield, D., Hatton, M., Lean, M., Sharma, P. & Han, T. 1 Jul 2017 In : Clinical Medicine. 17, 4, p. 293-297 5 p.

    Research output: Contribution to journalArticle

  25. Published

    Nutrition for the aging brain: towards evidence for an optimal diet

    Robles, M. C., Williams, R., Robles, M. C. & Ramirez, M. 1 May 2017 In : Ageing research reviews. 35, p. 222–240 19 p.

    Research output: Contribution to journalLiterature review

  26. Published

    Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies

    Sharma, P. & The Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, the Stroke Genetics Network (SiGN), and the International Stroke Genetics Consortium (ISGC)† 7 Apr 2017 In : Lancet Neurology. 15, 7, p. 695–707 13 p.

    Research output: Contribution to journalArticle

  27. Published

    PABPN1 gene therapy for oculopharyngeal muscular dystrophy

    Malerba, A., Klein, P., Bachtarzi, H., Jarmin, S. A., Cordova, G., Ferry, A., Strings, V., Espinoza, M. P., Mamchaoui, K., Blumen, S. C., St Guily, J. L., Mouly, V., Graham, M., Butler-Browne, G., Suhy, D. A., Trollet, C. & Dickson, G. 31 Mar 2017 In : Nature Communications. 8, p. 14848

    Research output: Contribution to journalArticle

  28. Published

    Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice

    Lu-Nguyen, N., Malerba, A., Popplewell, L., Schnell, F., Hanson, G. & Dickson, G. 17 Mar 2017 In : Molecular therapy. Nucleic acids. 6, p. 15-28 14 p.

    Research output: Contribution to journalArticle

  29. Published

    Protection of Penaeus monodon against white spot syndrome by continuous oral administration of a low concentration of Bacillus subtilis spores expressing the VP28 antigen

    Pham, K-C., Tran, H. T. T., Van Doan, C., Le, P. H., Van Nguyen, A. T., Nguyen, H. A., Huynh, H., Cutting, S. & Phan, T-N. Mar 2017 In : Letters in applied microbiology. 64, 3, p. 184-191 8 p.

    Research output: Contribution to journalArticle

  30. Published

    10 Years of Rare Disease Day

    Yáñez-Muñoz, R. J. Feb 2017 In : Gene Therapy. 24, 2, p. 67

    Research output: Contribution to journalEditorial

  31. Published
  32. Published

    Identifying the Molecular Mechanism of the MCT (Ketogenic) Diet

    Walker, M. & Williams, R. 5 Jan 2017 Ketogenic Diet and Metabolic Therapies : Expanded Roles in Health and Disease. Masino, S. (ed.). Oxford University Press

    Research output: Chapter in Book/Report/Conference proceedingChapter

  33. 2016
  34. E-pub ahead of print

    Meta-analysis of therapeutic hypothermia for traumatic brain injury in adult and paediatric patients

    Crompton, E., Lubormirova , I., Cotlarciuc, I., Han, T. & Sharma, P. 9 Dec 2016 In : Critical Care Medicine.

    Research output: Contribution to journalArticle

  35. Published
  36. Published

    Towards the genetic basis of cerebral venous thrombosis. The BEAST consortium: a study protocol

    Cotlarciuc, I. , Sharma, P. & 35 others Marjot, T., Khan, M., Hiltunen, S., Haapaniemi, E., Metso, T., Putaala, J., Zuurbier, S., Brouwer, M., Passamonti, S., Bucciarelli, P., Pappalardo, E., Patel, T., Costa, P., Colombi, M., Canhão, P., Tkach, A., Santacroce, R., Margaglione, M., Favuzzi, G., Grandone, E., Colaizzo, D., Spengos, K., Arauz, A., Hodge, A., Ditta, R., Debette, S., Zedde, M., Pare, G., Ferro, J., Thijs, V., Pezzini, A., Majersik, J., Martinelli, I., Coutinho, J. & Tatlisumak, T. 22 Nov 2016 In : BMJ Open.

    Research output: Contribution to journalArticle

  37. Published
  38. Published

    Democratizing neurorehabilitation: how accessible are low-cost mobile-gaming technologies for self-rehabilitation of arm disability in stroke?

    Rinne, P., Mace, M., Nakornchai, T., Zimmerman, K., Fayer, S., Sharma, P., Liardon, J-L., Burdet, E. & Bentley, P. 5 Oct 2016 In : PLoS One.

    Research output: Contribution to journalArticle

  39. Published

    Advances in gene therapy for muscular dystrophies

    Abdul-Razak, H., Malerba, A. & Dickson, G. 18 Aug 2016 In : F1000Research. 5, p. 1-7 7 p.

    Research output: Contribution to journalArticle

  40. Published

    Strain-dependent and distinctive T-cell responses to HIV antigens following immunisation of mice with differing chimpanzee adenovirus vaccine vectors

    Herath, S., Le Heron, A., Colloca, S., Patterson, S., Tatoud, R., Weber, J. & Dickson, G. 17 Aug 2016 In : Vaccine. 34, 37, p. 4378-85 8 p.

    Research output: Contribution to journalArticle

  41. Published

    Cytokine genes as potential biomarkers for muscle weakness in OPMD

    Riaz, M., Raz, Y., van der Slujis, B., Dickson, G., van Engelen, B., Vissing, J. & Raz, V. 9 Aug 2016 In : Human Molecular Genetics. p. 1-23 23 p.

    Research output: Contribution to journalArticle

  42. Published

    Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing

    Klein, P., Oloko, M., Roth, F., Montel, V., Malerba, A., Jarmin, S., Gidaro, T., Popplewell, L., Perie, S., Lacau St Guily, J., de la Grange, P., Antoniou, M. N., Dickson, G., Butler-Browne, G., Bastide, B., Mouly, V. & Trollet, C. 9 Aug 2016 In : Nucleic Acids Research.

    Research output: Contribution to journalArticle

  43. Published

    Antisense pre-treatment increases gene therapy efficacy in dystrophic muscles

    Peccate, C., Mollard, A., Le Hir, M., Julien, L., McClorey, G., Jarmin, S., Le Heron, A., Dickson, G., Benkhelifa-Ziyyat, S., Piétri-Rouxel, F., Wood, M. J., Voit, T. & Lorain, S. 4 Jul 2016 In : Human Molecular Genetics. p. 1-25 25 p.

    Research output: Contribution to journalArticle

  44. Published

    Intrastriatal delivery of integration-deficient lentiviral vectors in a rat model of Parkinson's disease

    Lu-Nguyen, N., Broadstock, M. & Yáñez-Muñoz, R. J. 18 Jun 2016 In : Methods in Molecular Biology. 1448, p. 175-184 10 p.

    Research output: Contribution to journalArticle

  45. Published

    Employing Dictyostelium as an Advantageous 3Rs Model for Pharmacogenetic Research

    Otto, G., Cocorocchio, M., Munoz, L., Tyson, R., Bretschneider, T. & Williams, R. 7 Jun 2016 Methods in Molecular Biology: Chemotaxis. Springer New York: Springer, Vol. 1407, p. 123-130 8 p. (Methods in Molecular Biology; vol. 1407)

    Research output: Chapter in Book/Report/Conference proceedingChapter

  46. Published

    Non-Catalytic Roles of Presenilin throughout evolution

    Otto, G., Sharma, D. & Williams, R. 7 Jun 2016 In : Journal of Alzheimer's Disease. 52, 4, p. 177-1187 11 p.

    Research output: Contribution to journalLiterature review

  47. Published

    Non-invasive early detection and stratification of breast cancer

    Alsaidi, Y., Milnthorpe, A. & Soloviev, M. 28 May 2016

    Research output: Contribution to conferencePoster

  48. Published

    Alzheimer disease research in the 21st century: past and current failures, new perspectives and funding priorities: Funding priorities in Alzheimer disease research

    Pistollato, F., Ohayon, E., Lam, A., Langley, G., Novak, T., Pamies, D., Perry, G., Trushina, E., Williams, R., Roher, A., hartung, T., Merkley, R. & Chandrasekera, C. 4 May 2016 In : Oncotarget. p. 1-18 18 p.

    Research output: Contribution to journalLiterature review

  49. Published

    The inositol-3-phosphate synthase biosynthetic enzyme has distinct catalytic and metabolic roles

    Frej, A., Clark, J., Le Roy, C., Lilla, S., Thomason, P., Otto, G., Churchill, G., Insall, R., Claus, S., Hawkins, P., Stephens, L. & Williams, R. 1 May 2016 In : Molecular and Cellular Biology. 36, 10, p. 1464-1479 16 p.

    Research output: Contribution to journalArticle

  50. Published
  51. Published

    Low-frequency and common genetic variation in ischemic stroke: The METASTROKE collaboration

    Cotlarciuc, I. , Sharma, P. & 48 others Malik, R., Traylor, M., Pulit, S. L., Bevan, S., Hopewell, J. C., Holliday, E. G., Zhao, W., Abrantes, P., Amouyel, P., Attia, J. R., Battey, T. W. K., Berger, K., Boncoraglio, G. B., Chauhan, G., Cheng, Y-C., Chen, W-M., Clarke, R., Debette, S., Falcone, G. J., Ferro, J. M., Gamble, D. M., Ilinca, A., Kittner, S. J., Kourkoulis, C. E., Lemmens, R., Levi, C. R., Lichtner, P., Lindgren, A., Liu, J., Meschia, J. F., Mitchell, B. D., Oliveira, S. A., Pera, J., Reiner, A. P., Rothwell, P. M., Slowik, A., Sudlow, C. L. M., Tatlisumak, T., Thijs, V., Vicente, A. M., Woo, D., Seshadri, S., Saleheen, D., Rosand, J., Markus, H. S., Worrall, B. B., Dichgans, M. & ISGC Analysis Group 29 Mar 2016 In : Neurology. 86, 13, p. 1217-26 10 p.

    Research output: Contribution to journalArticle

  52. Published

    Current Progress in Therapeutic Gene Editing for Monogenic Diseases

    Prakash, V., Moore, M. & Yáñez-Muñoz, R. J. Mar 2016 In : Molecular Therapy. 24, 3, p. 465-474 10 p.

    Research output: Contribution to journalArticle

  53. Published

    Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization Study

    Cheng, Y-C. , Sharma, P. & 55 others Keenan, T., Zhao, W., Rasheed, A., Ho, W. K., Malik, R., Felix, J. F., Young, R., Shah, N., Samuel, M., Sheikh, N., Mucksavage, M. L., Shah, O., Li, J., Morley, M., Laser, A., Mallick, N. H., Zaman, K. S., Ishaq, M., Rasheed, S. Z., Memon, F-U-R., Ahmed, F., Hanif, B., Lakhani, M. S., Fahim, M., Ishaq, M., Shardha, N. K., Ahmed, N., Mahmood, K., Iqbal, W., Akhtar, S., Raheel, R., O'Donnell, C. J., Hengstenberg, C., März, W., Kathiresan, S., Samani, N., Goel, A., Hopewell, J. C., Chambers, J., Yang, Q., Rosand, J., Boncoraglio, G. B., Kazmi, S. U., Hakonarson, H., Köttgen, A., Kalogeropoulos, A., Frossard, P., Kamal, A., Dichgans, M., Cappola, T., Reilly, M. P., Danesh, J., Rader, D. J., Voight, B. F. & Saleheen, D. 2 Feb 2016 In : Journal of the American College of Cardiology. 67, 4, p. 407-16 10 p.

    Research output: Contribution to journalArticle

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