Centre for Biomedical Sciences

Projects

Projects per year 2000 2010 2011 2012 2013 2015 2016 2021 2022 2026

• 3 Active
• 4 Not started
• 65 Finished

Projects per year

Search results

• Active

  Improving protein folding to enhance microdystrophin expression in Duchenne muscular dystrophy

  Malerba, A. (PI)

  AFM Telethon

  1/11/24 → 31/10/26

  Project: Research

• Protein folding strategies to enhance microdystrophin expression in Duchenne Muscular Dystrophy

  Boulinguiez, A. (Fellow) & Malerba, A. (Mentor)

  AFM Telethon

  1/11/24 → 31/10/26

  Project: Research

• Replacing valproate with a safer, broad-spectrum drug for epilepsy treatment

  Williams, R. (PI)

  Medical Research Council MRC

  1/04/24 → 31/03/26

  Project: Research

• Not started

  Combining CRISPRa-mediated inhibition of fibrosis with U7snRNAmediated exon skipping for Dystrophin rescue for Duchenne muscular dystrophy gene therapy

  March, J. (PI) & Malerba, A. (Mentor)

  Duchenne Parent Project

  1/01/25 → 31/12/25

  Project: Research

• Identifying novel molecular mechanisms of action of THCA, THCV adn CBG using Dictyostelium

  Williams, R. (PI)

  Project: Research

• Purchase of a shutter for IX711 : Microscope:research involving analyzing the uptake of epilepsy treatment

  Williams, R. (PI)

  University of London Central Research Fund

  Project: Research

• Replacing valproate with a safer, broad-spectrum drug for epilepsy treatment

  Williams, R. (PI)

  Project: Research

• Finished

  To develop an assay capable of evaluating whether MitoRx compounds ameliorate the effects of oxidative stress on mitochondrial bioenergetics in DMD patient cells

  Malerba, A. (PI)

  MitoRx Therapeutics Limited

  1/02/23 → 31/10/23

  Project: Research

• To develop an assay capable of evaluating whether MitoRx compounds ameliorate the effects of oxidative stress on mitochondrial bioenergetics in DMD patient cells

  Lu-Nguyen, N. (Researcher) & Malerba, A. (PI)

  1/02/23 → 31/10/23

  Project: Research

• Proof‐of‐concept demonstration that combined dystrophin restoration and periostin manipulation synergistically improve skeletal muscle pathology

  Lu-Nguyen, N. (Researcher), Boulinguiez, A. (Researcher) & Malerba, A. (PI)

  1/01/23 → 31/12/23

  Project: Research

• Metabolomic investigation of the effects of nonanoic acid and 4-MOA in a C9Orf72 Drosophila model of ALS

  Augustin, H. (PI) & Snowden, S. (CoI)

  Motor Neurone Disease Association

  15/08/22 → 14/10/22

  Project: Research

• Enhanced Steady-State Levels of Exon Skipped and gene therapy expressed “BMD-LIKE” Dystrophins Through Unfolded Protein Response (UPR) inhibition

  Malerba, A. (PI)

  Muscular Dystrophy UK

  3/05/22 → 2/05/23

  Project: Research

• An investigation of the synaptic role of the proto-oncogene Yorkie at the Drosophila larval neuromuscular junction

  Augustin, H. (PI)

  Royal Society

  21/03/22 → 20/09/23

  Project: Research

• In Vivo Evaluation of Muscle Specific Synthetic Promoters

  Popplewell, L. (PI) & Malerba, A. (PI)

  SynPromics Ltd

  14/03/22 → 31/03/23

  Project: Research

• In Vivo Evaluation of Muscle Specific Synthetic Promoters

  Lu-Nguyen, N. (Researcher), Popplewell, L. (CoPI) & Malerba, A. (PI)

  14/03/22 → 31/03/23

  Project: Research

• Proof of concept study: Local in vivo delivery

  Popplewell, L. (PI)

  Replay Holdings LLC

  1/01/22 → 31/03/23

  Project: Research

• Identifying metabolic signatures of pathology in muscle and blood to identify biomarkers of oculopharyngeal muscular dystrophy.

  Snowden, S. (PI) & Popplewell, L. (CoI)

  AFM Telethon

  1/09/21 → 31/08/22

  Project: Research

• Identification of novel modifiers of synaptic function, neurodegeneration and longevity in a Drosophila FTD/ALS model

  Augustin, H. (PI)

  Academy of Medical Sciences

  1/06/21 → 30/11/23

  Project: Research

• Optimisation of a gene therapy for Oculopharyngeal muscular dystrophy

  Popplewell, L. (PI) & Malerba, A. (CoI)

  LifeArc

  17/05/21 → 16/05/24

  Project: Research

• Delivery of codon-optimised full-length dystrophin to muscle using 4BaseBio non-viral methodology - Phase 1

  Popplewell, L. (PI)

  4BaseBio Discovery

  4/05/21 → 3/10/21

  Project: Research

• Pilot Study

  Popplewell, L. (PI)

  Healx

  4/05/21 → 3/08/21

  Project: Research

• Exon skipping to treat Neurofibromatosis Type I (NF1) mutations

  Dickson, G. (CoI) & Popplewell, L. (PI)

  Gilbert Family Foundation

  1/12/18 → 31/01/23

  Project: Research

• Universal Microdystrophin (MD) Gene Therapy Clinical Trial for DMD (UNITE-DMD)

  Dickson, G. (PI), Popplewell, L. (CoI) & Malerba, A. (Researcher)

  Muscular Dystrophy UK

  1/07/17 → 30/06/21

  Project: Other

• Identifying the underlying mechanisms of medium chain fatty acids in health using a simple model system

  Williams, R. (PI)

  Biotechnology&BioSci Research BBSRC

  5/09/16 → 4/09/20

  Project: Research

• Identifying novel molecular mechanisms of action of THCA, THCV, and CBG using Dictyostelium

  Williams, R. (PI)

  GW Research Ltd

  2/08/16 → 1/02/20

  Project: Other

• Development of genome editing surgery with applicability to all DMD patients

  Popplewell, L. (PI)

  1/07/16 → 31/12/16

  Project: Research

• An investigation into the role of Rp131 and regulation of ribosome biogenesis in the pathogenesis of Duchenne muscular dystrophy implications for novel therapeutic strategies

  Popplewell, L. (PI)

  Neurological Foundation of New Zealand - Philip Wrightson Fellowship

  1/04/16 → 31/03/18

  Project: Other

• Extensionof NC3R project collaboration

  Williams, R. (PI)

  1/01/16 → 31/03/16

  Project: Research

• The UK Spinal Muscular Atrophy Research Consortium

  Yáñez-Muñoz, R. J. (PI)

  The SMA Trust

  1/01/16 → 3/03/20

  Project: Research

• Funding to support a nurse/clinician at Royal Holloway College to help identify patients poorly controlled or not anticoagulated

  Sharma, P. (PI)

  Bayer PLC

  1/01/16 → 30/06/16

  Project: Research

• Enhancement of splicing efficiency between trans-spliced DMD AAV vectors for the production of full-length fully functional dystrophin protein

  Dickson, G. (PI)

  1/01/16 → 1/01/17

  Project: Research

• Development of broadly applicable combinatorial genome editing and antisense therapies for Duchenne muscular dystrophy addressing dystrophin deficiency, muscle wasting and muscle fibrosis

  Popplewell, L. (PI)

  Muscular Dystrophy UK

  1/10/15 → 30/09/16

  Project: Research

• Stage 2 study on DNA-directed RNAi for the treatment of OPMd

  Dickson, G. (PI)

  Benitec Ltd

  1/09/15 → 31/08/16

  Project: Research

• BRAINS study

  Sharma, P. (PI)

  1/07/15 → 31/12/15

  Project: Research

• Towards a sustainable resource in stroke genetics from the four corners of India: the 4i study

  Sharma, P. (PI)

  British Council

  17/05/15 → 16/01/16

  Project: Research

• Towards the identification of cerebrovascular disease genes in South Asians: a major grant initiative

  Sharma, P. (PI)

  Royal Society

  25/03/15 → 26/03/15

  Project: Research

• Building a highly characterized DNA repository on haemorrhagic stroke in Qatar

  Sharma, P. (PI)

  Hamad Medical Corporation

  1/09/14 → 30/11/16

  Project: Research

• Towards a clinical trial for Oculopharyngeal Muscular Dystrophy

  Malerba, A. (Researcher), Lu-Nguyen, N. (Researcher), Harish, P. (Student) & Dickson, G. (PI)

  Association Francais contre les Myopathies

  1/07/14 → 30/06/19

  Project: Research

• NanoLiquid

  Odarchenko, Y. (Researcher), Soloviev, M. (PI) & Petrashov, V. (CoI)

  1/06/14 → 30/11/15

  Project: Research

• The effect of aggresomes on centrosome function

  Wilkinson, C. (PI)

  Parkinson's UK

  4/06/13 → 3/06/14

  Project: Research

• Society of Applied Microbiology award-Niccolo Monaco

  Cutting, S. (PI)

  Society for Applied Microbiology

  3/06/13 → 4/08/13

  Project: Research

• Oral Vaccination against Clostridium difficile Infection

  Cutting, S. (PI) & Huynh, H. (CoI)

  European Commission

  1/06/13 → 30/11/16

  Project: Research

• MICA: Development of a Clostridium difficile Vaccine

  Cutting, S. (PI)

  Medical Research Council MRC

  1/04/13 → 31/03/15

  Project: Research

• Gene Surgery for Duchenne Muscular Dystrophy(DMD)

  Dickson, G. (PI) & Yáñez-Muñoz, R. J. (CoI)

  Association Francais contre les Myopathies

  1/04/13 → 31/03/15

  Project: Research

• Using patient-specific induced pluripotent stem cells to investigate the molecular mechanism of CADASIL

  Sharma, P. (PI)

  British Heart Foundation

  1/01/13 → 31/12/15

  Project: Research

• Phase I/IIa clinical trial in Duchenne muscular dystrophy using systematically delivered morpholino antisense oligomer to skip exon 53.

  Dickson, G. (PI)

  European Union

  1/11/12 → 31/10/15

  Project: Research

• Development of an antisense oligonucleotide based strategy to manipulate RNA editing of AMPA receptor subunits in cell lines and motor neurones

  Chen, P. (PI)

  Motor Neurone Disease Association

  1/10/12 → 30/09/15

  Project: Research

• Antibiotic resistance in biofilms

  McEvoy, J. (PI) & Raymond, B. (CoI)

  Skyes Trust, Charles and Elsie Sykes Trust

  1/10/12 → 30/09/15

  Project: Research

• DNA-Directed RNAi (ddRNAi) to inhibit expression of the gene product (PABPN1) involved in the aetiology of the inclusion body disease, Oculopharyngeal Muscular Dystrophy (OPMD)

  Dickson, G. (PI)

  Benitec Ltd

  1/01/12 → 30/06/13

  Project: Research

• Investigating novel Tulp3-interacting proteins as regulators of the Sonic hedgehog signalling pathways

  Murdoch, J. (PI)

  Royal Society

  1/06/11 → 31/05/12

  Project: Research