Local but not long-range microstructural differences of the ventral temporal cortex in developmental prosopagnosia

Sunbin Song, Lucia Garrido, Zoltan Nagy, Siawoosh Mohammadi, Adam Steel, Jon Driver, Bradley Duchaine, Nicholas Furl

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Abstract

Individuals with developmental prosopagnosia (DP) experience face recognition impairments despite normal intellect and low-level vision and no history of brain damage. Prior studies using diffusion tensor imaging in small samples of subjects with DP (n=6 or n=8) offer conflicting views on the neurobiological bases for DP, with one suggesting white matter differences in two major long-range tracts running through the temporal cortex, and another suggesting white matter differences confined to fibers local to ventral temporal face-specific functional regions of interest (fROIs) in the fusiform gyrus. Here, we address these inconsistent findings using a comprehensive set of analyzes in a sample of DP subjects larger than both prior studies combined (n=16). While we found no microstructural differences in long-range tracts between DP and age-matched control participants, we found differences local to face-specific fROIs, and relationships between these microstructural measures with face recognition ability. We conclude that subtle differences in local rather than long-range tracts in the ventral temporal lobe are more likely associated with developmental prosopagnosia.
Original languageEnglish
Pages (from-to)195–206
Number of pages12
JournalNeuropsychologia
Volume78
Early online date9 Oct 2015
DOIs
Publication statusPublished - Nov 2015

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