Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

P. E. Chen, M. T. Geballe, P. J. Stansfeld, A. R. Johnston, H. Yuan, A. L. Jacob, J. P. Snyder, S. F. Traynelis, D. J. Wyllie

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1470-84
Number of pages15
JournalMolecular Pharmacology
Issue number5
Publication statusPublished - 2005


  • Amino Acid Sequence Animals Binding Sites/drug effects/physiology Dose-Response Relationship, Drug Excitatory Amino Acid Agonists/metabolism/pharmacology Female *Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed/drug effects/*physiology Receptors, N-Methyl-D-Aspartate/chemistry/genetics/*metabolism Recombinant Proteins/chemistry/genetics/metabolism Xenopus laevis

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