Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice

Eyman Osman, Vanessa Evans, Ian R Graham, Takis Athanasopoulos, Jenny McIntosh, Amit C Nathwani, J Paul Simons, George Dickson, James S Owen

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)121-6
Number of pages6
Issue number1
Publication statusPublished - 2009


  • Animals
  • Aorta
  • Apolipoprotein E3
  • Apolipoproteins E
  • Atherosclerosis
  • Cell Line, Tumor
  • Cholesterol
  • Dependovirus
  • Disease Models, Animal
  • Female
  • Gene Therapy
  • Genetic Vectors
  • Humans
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Lipoproteins, VLDL
  • Liver
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Pilot Projects
  • Promoter Regions, Genetic
  • Sex Factors
  • Time Factors
  • Transduction, Genetic

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