Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3 beta inhibition, and viral replication: A screening approach for new bipolar disorder drugs derived from the valproic acid core structure

B J  Eickholt; G J  Towers; W J  Ryves; D  Eikel; K  Adley; L M J  Ylinen; N H  Chadborn; A J  Harwood; H  Nau; R S B  Williams

doi:10.1124/mol.104.009308

Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3 beta inhibition, and viral replication: A screening approach for new bipolar disorder drugs derived from the valproic acid core structure

B J Eickholt, G J Towers, W J Ryves, D Eikel, K Adley, L M J Ylinen, N H Chadborn, A J Harwood, H Nau, R S B Williams

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1426-1433
Number of pages	8
Journal	Molecular Pharmacology
Volume	67
Issue number	5
DOIs	https://doi.org/10.1124/mol.104.009308
Publication status	Published - May 2005

Keywords

HIV-POSITIVE PATIENTS
HISTONE DEACETYLASE
SODIUM VALPROATE
ANTICONVULSANT ACTIVITY
RAT-BRAIN
LITHIUM
PHARMACOKINETICS
MECHANISM
DECREASE
TARGET

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1124/mol.104.009308

Cite this

Eickholt, B. J., Towers, G. J., Ryves, W. J., Eikel, D., Adley, K., Ylinen, L. M. J., Chadborn, N. H., Harwood, A. J., Nau, H., & Williams, R. S. B. (2005). Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3 beta inhibition, and viral replication: A screening approach for new bipolar disorder drugs derived from the valproic acid core structure. Molecular Pharmacology, 67(5), 1426-1433. https://doi.org/10.1124/mol.104.009308

Eickholt, B J ; Towers, G J ; Ryves, W J et al. / Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3 beta inhibition, and viral replication: A screening approach for new bipolar disorder drugs derived from the valproic acid core structure. In: Molecular Pharmacology. 2005 ; Vol. 67, No. 5. pp. 1426-1433.

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keywords = "HIV-POSITIVE PATIENTS, HISTONE DEACETYLASE, SODIUM VALPROATE, ANTICONVULSANT ACTIVITY, RAT-BRAIN, LITHIUM, PHARMACOKINETICS, MECHANISM, DECREASE, TARGET",

author = "Eickholt, {B J} and Towers, {G J} and Ryves, {W J} and D Eikel and K Adley and Ylinen, {L M J} and Chadborn, {N H} and Harwood, {A J} and H Nau and Williams, {R S B}",

year = "2005",

month = may,

doi = "10.1124/mol.104.009308",

language = "English",

volume = "67",

pages = "1426--1433",

journal = "Molecular Pharmacology",

issn = "0026-895X",

publisher = "American Society for Pharmacology and Experimental Therapeutics",

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Eickholt, BJ, Towers, GJ, Ryves, WJ, Eikel, D, Adley, K, Ylinen, LMJ, Chadborn, NH, Harwood, AJ, Nau, H & Williams, RSB 2005, 'Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3 beta inhibition, and viral replication: A screening approach for new bipolar disorder drugs derived from the valproic acid core structure', Molecular Pharmacology, vol. 67, no. 5, pp. 1426-1433. https://doi.org/10.1124/mol.104.009308

Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3 beta inhibition, and viral replication: A screening approach for new bipolar disorder drugs derived from the valproic acid core structure. / Eickholt, B J ; Towers, G J ; Ryves, W J et al.
In: Molecular Pharmacology, Vol. 67, No. 5, 05.2005, p. 1426-1433.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3 beta inhibition, and viral replication: A screening approach for new bipolar disorder drugs derived from the valproic acid core structure

AU - Eickholt, B J

AU - Towers, G J

AU - Ryves, W J

AU - Eikel, D

AU - Adley, K

AU - Ylinen, L M J

AU - Chadborn, N H

AU - Harwood, A J

AU - Nau, H

AU - Williams, R S B

PY - 2005/5

Y1 - 2005/5

KW - HIV-POSITIVE PATIENTS

KW - HISTONE DEACETYLASE

KW - SODIUM VALPROATE

KW - ANTICONVULSANT ACTIVITY

KW - RAT-BRAIN

KW - LITHIUM

KW - PHARMACOKINETICS

KW - MECHANISM

KW - DECREASE

KW - TARGET

U2 - 10.1124/mol.104.009308

DO - 10.1124/mol.104.009308

M3 - Article

SN - 0026-895X

VL - 67

SP - 1426

EP - 1433

JO - Molecular Pharmacology

JF - Molecular Pharmacology

IS - 5

ER -

Eickholt BJ, Towers GJ, Ryves WJ, Eikel D, Adley K, Ylinen LMJ et al. Effects of valproic acid derivatives on inositol trisphosphate depletion, teratogenicity, glycogen synthase kinase-3 beta inhibition, and viral replication: A screening approach for new bipolar disorder drugs derived from the valproic acid core structure. Molecular Pharmacology. 2005 May;67(5):1426-1433. doi: 10.1124/mol.104.009308