Diagnostic accuracy of auto-fluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma

Radu Boitor; Sandeep Varma; Ashish Sharma; Sunita  Odedra; Somaia Elsheikh; Karim Eldib; Anand Patel; Alexey Koloydenko; Sonia Gran; Koen De Winne; Senada Koljenovic; Hywel Williams; Ioan Notingher

Diagnostic accuracy of auto-fluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma

Radu Boitor, Sandeep Varma, Ashish Sharma, Sunita Odedra, Somaia Elsheikh, Karim Eldib, Anand Patel, Alexey Koloydenko, Sonia Gran, Koen De Winne, Senada Koljenovic, Hywel Williams, Ioan Notingher

Research output: Contribution to journal › Article › peer-review

Abstract

Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma
(BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohs
surgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130
patients) shows that with improvement in tissue processing, the AF-Raman instrument is viable
technique for intra-operative assessment of surgical margins.

Original language	English
Journal	British Journal of Dermatology
Publication status	Submitted - 15 Mar 2024

Keywords

Mohs, Basal cell carcinoma, Evidence-based dermatology

Cite this

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title = "Diagnostic accuracy of auto-fluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma",

abstract = "Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma(BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohssurgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130patients) shows that with improvement in tissue processing, the AF-Raman instrument is viabletechnique for intra-operative assessment of surgical margins.",

keywords = "Mohs, Basal cell carcinoma, Evidence-based dermatology",

author = "Radu Boitor and Sandeep Varma and Ashish Sharma and Sunita Odedra and Somaia Elsheikh and Karim Eldib and Anand Patel and Alexey Koloydenko and Sonia Gran and {De Winne}, Koen and Senada Koljenovic and Hywel Williams and Ioan Notingher",

year = "2024",

month = mar,

day = "15",

language = "English",

journal = "British Journal of Dermatology",

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TY - JOUR

T1 - Diagnostic accuracy of auto-fluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma

AU - Boitor, Radu

AU - Varma, Sandeep

AU - Sharma, Ashish

AU - Odedra, Sunita

AU - Elsheikh, Somaia

AU - Eldib, Karim

AU - Patel, Anand

AU - Koloydenko, Alexey

AU - Gran, Sonia

AU - De Winne, Koen

AU - Koljenovic, Senada

AU - Williams, Hywel

AU - Notingher, Ioan

PY - 2024/3/15

Y1 - 2024/3/15

N2 - Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma(BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohssurgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130patients) shows that with improvement in tissue processing, the AF-Raman instrument is viabletechnique for intra-operative assessment of surgical margins.

AB - Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma(BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohssurgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130patients) shows that with improvement in tissue processing, the AF-Raman instrument is viabletechnique for intra-operative assessment of surgical margins.

KW - Mohs, Basal cell carcinoma, Evidence-based dermatology

M3 - Article

JO - British Journal of Dermatology

JF - British Journal of Dermatology

ER -