Diagnostic accuracy of auto-fluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma

Radu Boitor, Sandeep Varma, Ashish Sharma, Sunita Odedra, Somaia Elsheikh, Karim Eldib, Anand Patel, Alexey Koloydenko, Sonia Gran, Koen De Winne, Senada Koljenovic, Hywel Williams, Ioan Notingher

Research output: Contribution to journalArticlepeer-review


Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma
(BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohs
surgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130
patients) shows that with improvement in tissue processing, the AF-Raman instrument is viable
technique for intra-operative assessment of surgical margins.
Original languageEnglish
JournalBritish Journal of Dermatology
Publication statusSubmitted - 15 Mar 2024


  • Mohs, Basal cell carcinoma, Evidence-based dermatology

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