Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan. / Niino, Masaaki ; Fukazawa, Toshiyuki; Kira, Jun-ichi; Okuno, Tatsusada; Mori, Masahiro; Sanjo, Nobuo ; Ohashi, Takashi; Fukaura, Hikoaki; Fujimori, Juichi; Shimizu, Yuko; Mifune, Nobuhiro; Miyazaki, Yusei; Takahashi, Eri; Kikuchi, Seiji; Langdon, Dawn; Benedict, Ralph; Matsui, Makoto.

In: Multiple Sclerosis Journal: Experimental, Translational and Clinical, Vol. 3, No. 4, 26.12.2017, p. 1-8.

Research output: Contribution to journalArticlepeer-review

  • Masaaki Niino
  • Toshiyuki Fukazawa
  • Jun-ichi Kira
  • Tatsusada Okuno
  • Masahiro Mori
  • Nobuo Sanjo
  • Takashi Ohashi
  • Hikoaki Fukaura
  • Juichi Fujimori
  • Yuko Shimizu
  • Nobuhiro Mifune
  • Yusei Miyazaki
  • Eri Takahashi
  • Seiji Kikuchi
  • Dawn Langdon
  • Ralph Benedict
  • Makoto Matsui



The Brief International Cognitive Assessment for MS (BICAMS) is a practical battery for measuring cognitive function in multiple sclerosis (MS).


We aimed to validate a Japanese version of the BICAMS in patients with MS and healthy controls.


The Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-Second Edition (CVLT2) and the Brief Visuospatial Memory Test Revised (BVMTR) were administered to 156 patients with MS and 126 healthy controls (HCs). The BICAMS was re-administered in a subset of 27 MS patients and 30 HCs.


The mean (±SD) raw scores in the MS and HC groups were as follows: SDMT: MS 47.9 ± 14.0, HC 61.0 ± 9.5; CVLT2: MS 48.6 ± 12.6, HC 55.7 ± 10.5; BVMTR: MS 23.5 ± 8.4, HC 28.3 ± 5.4, respectively, and significant differences were found between the two groups on all tests (p < 0.0001). Cohen’s d values were 1.07, 0.60, and 0.67 in SDMT, CVLT2, and BVMTR, respectively. The test-retest reliability coefficients for each test were as follows: SDMT: r = 0.93; CVLT2: r = 0.82; and BVMTR: r = 0.77 (p < 0.0001).


This study provides results that support the reliability and validity of the BICAMS in Japan.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalMultiple Sclerosis Journal: Experimental, Translational and Clinical
Issue number4
Publication statusPublished - 26 Dec 2017
This open access research output is licenced under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.

ID: 29270432