Towards a therapeutic inhibition of dystrophin exon 23 splicing in mdx mouse muscle induced by antisense oligoribonucleotides (splicomers): target sequence optimisation using oligonucleotide arrays

Ian R Graham, Vanessa J Hill, Muthiah Manoharan, Gopal B Inamati, George Dickson

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1149-58
Number of pages10
JournalJournal of Gene Medicine
Volume6
Issue number10
DOIs
Publication statusPublished - 2004

Keywords

  • Alleles
  • Alternative Splicing
  • Animals
  • Base Sequence
  • Blotting, Western
  • DNA
  • Dose-Response Relationship, Drug
  • Dystrophin
  • Exons
  • Frameshift Mutation
  • Gene Therapy
  • Immunohistochemistry
  • Introns
  • Mice
  • Mice, Inbred C57BL
  • Mice, Inbred mdx
  • Molecular Sequence Data
  • Muscles
  • Muscular Dystrophy, Duchenne
  • Nucleic Acid Hybridization
  • Oligonucleotide Array Sequence Analysis
  • Oligonucleotides, Antisense
  • Protein Binding
  • RNA
  • RNA Splicing
  • RNA, Messenger
  • Reverse Transcriptase Polymerase Chain Reaction
  • Transfection

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