Titanium Kirschner Wires Resist Biofilms Better Than Stainless Steel and Hydroxyapatite-coated Wires : An In Vitro Study. / McEvoy, James; Martin, Philip; Khaleel, Arshad; Dissanayeke, Shobana.

In: Strategies in Trauma and Limb Reconstruction, Vol. 14, No. 2, 2019, p. 57-64.

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Titanium Kirschner Wires Resist Biofilms Better Than Stainless Steel and Hydroxyapatite-coated Wires : An In Vitro Study. / McEvoy, James; Martin, Philip; Khaleel, Arshad; Dissanayeke, Shobana.

In: Strategies in Trauma and Limb Reconstruction, Vol. 14, No. 2, 2019, p. 57-64.

Research output: Contribution to journalArticle

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@article{02cb9b01adbf4b30802529b419171b30,
title = "Titanium Kirschner Wires Resist Biofilms Better Than Stainless Steel and Hydroxyapatite-coated Wires: An In Vitro Study",
abstract = "Aim: External fixation surgery is frequently complicated by percutaneous pin site infection focused on the surface of the fixator pin. The primary aim of this study was to compare biofilm growth of clinically isolated pin site bacteria on Kirschner wires of different materials. Materials and methods: Two commonly infecting species, Staphylococcus epidermidis and Proteus mirabilis, were isolated from patients{\textquoteright} pin sites. A stirred batch bioreactor was used to grow these bacteria as single culture and co-cultured biofilms on Kirschner wires made of three different materials: stainless steel, hydroxyapatite-coated steel and titanium alloy. Results: We found that the surface density of viable cells within these biofilms was 3x higher on stainless steel and 4.5x higher on hydroxyapatitecoated wires than on the titanium wires. Conclusion: Our results suggest that the lower rates of clinical pin site infection seen with titanium Kirschner wires are due to, at least in part, titanium{\textquoteright}s better bacterial biofilm resistance. Clinical significance: Our results are consistent with clinical studies which have found that pin site infection rates are reduced by the use of titanium relative to stainless steel or hydroxyapatite-coated pins.",
author = "James McEvoy and Philip Martin and Arshad Khaleel and Shobana Dissanayeke",
year = "2019",
doi = "10.5005/jp-journals-10080-1426",
language = "English",
volume = "14",
pages = "57--64",
journal = "Strategies in Trauma and Limb Reconstruction",
issn = "1828-8936",
publisher = "Springer-Verlag Italia",
number = "2",

}

RIS

TY - JOUR

T1 - Titanium Kirschner Wires Resist Biofilms Better Than Stainless Steel and Hydroxyapatite-coated Wires

T2 - An In Vitro Study

AU - McEvoy, James

AU - Martin, Philip

AU - Khaleel, Arshad

AU - Dissanayeke, Shobana

PY - 2019

Y1 - 2019

N2 - Aim: External fixation surgery is frequently complicated by percutaneous pin site infection focused on the surface of the fixator pin. The primary aim of this study was to compare biofilm growth of clinically isolated pin site bacteria on Kirschner wires of different materials. Materials and methods: Two commonly infecting species, Staphylococcus epidermidis and Proteus mirabilis, were isolated from patients’ pin sites. A stirred batch bioreactor was used to grow these bacteria as single culture and co-cultured biofilms on Kirschner wires made of three different materials: stainless steel, hydroxyapatite-coated steel and titanium alloy. Results: We found that the surface density of viable cells within these biofilms was 3x higher on stainless steel and 4.5x higher on hydroxyapatitecoated wires than on the titanium wires. Conclusion: Our results suggest that the lower rates of clinical pin site infection seen with titanium Kirschner wires are due to, at least in part, titanium’s better bacterial biofilm resistance. Clinical significance: Our results are consistent with clinical studies which have found that pin site infection rates are reduced by the use of titanium relative to stainless steel or hydroxyapatite-coated pins.

AB - Aim: External fixation surgery is frequently complicated by percutaneous pin site infection focused on the surface of the fixator pin. The primary aim of this study was to compare biofilm growth of clinically isolated pin site bacteria on Kirschner wires of different materials. Materials and methods: Two commonly infecting species, Staphylococcus epidermidis and Proteus mirabilis, were isolated from patients’ pin sites. A stirred batch bioreactor was used to grow these bacteria as single culture and co-cultured biofilms on Kirschner wires made of three different materials: stainless steel, hydroxyapatite-coated steel and titanium alloy. Results: We found that the surface density of viable cells within these biofilms was 3x higher on stainless steel and 4.5x higher on hydroxyapatitecoated wires than on the titanium wires. Conclusion: Our results suggest that the lower rates of clinical pin site infection seen with titanium Kirschner wires are due to, at least in part, titanium’s better bacterial biofilm resistance. Clinical significance: Our results are consistent with clinical studies which have found that pin site infection rates are reduced by the use of titanium relative to stainless steel or hydroxyapatite-coated pins.

U2 - 10.5005/jp-journals-10080-1426

DO - 10.5005/jp-journals-10080-1426

M3 - Article

VL - 14

SP - 57

EP - 64

JO - Strategies in Trauma and Limb Reconstruction

JF - Strategies in Trauma and Limb Reconstruction

SN - 1828-8936

IS - 2

ER -