Tipping the scales : Lessons from simple model systems on inositol imbalance in neurological disorders. / Frej, Anna; Otto, Grant; Williams, Robin.

In: EUROPEAN JOURNAL OF CELL BIOLOGY, Vol. 96, No. 2, 03.2017, p. 154–163.

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Tipping the scales : Lessons from simple model systems on inositol imbalance in neurological disorders. / Frej, Anna; Otto, Grant; Williams, Robin.

In: EUROPEAN JOURNAL OF CELL BIOLOGY, Vol. 96, No. 2, 03.2017, p. 154–163.

Research output: Contribution to journalLiterature reviewpeer-review

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@article{73b7fa2baf024ca1a24864a5cb548ab5,
title = "Tipping the scales: Lessons from simple model systems on inositol imbalance in neurological disorders",
abstract = "Inositol and inositol-containing compounds have signalling and regulatory roles in many cellular processes, suggesting that inositol imbalance may lead to wide-ranging changes in cellular functions. Indeed, changes in inositol-dependent signalling have been implicated in various diseases and cellular functions such as autophagy, and these changes have often been proposed as therapeutic targets. However, few studies have highlighted the links between inositol depletion and the downstream effects on inositol phosphates and phosphoinositides in disease states. For this research, many advances have employed simple model systems that include the social amoeba D. discoideum and the yeast S. cerevisiae, since these models enable a range of experimental approaches that are not possible in mammalian models. In this review, we discuss recent findings initiated in simple model systems and translated to higher model organisms where the effect of altered inositol, inositol phosphate and phosphoinositide levels impact on bipolar disorder, Alzheimer disease, epilepsy and autophagy.",
author = "Anna Frej and Grant Otto and Robin Williams",
year = "2017",
month = mar,
doi = "10.1016/j.ejcb.2017.01.007",
language = "English",
volume = "96",
pages = "154–163",
journal = "EUROPEAN JOURNAL OF CELL BIOLOGY",
issn = "0171-9335",
publisher = "Urban und Fischer Verlag GmbH und Co. KG",
number = "2",

}

RIS

TY - JOUR

T1 - Tipping the scales

T2 - Lessons from simple model systems on inositol imbalance in neurological disorders

AU - Frej, Anna

AU - Otto, Grant

AU - Williams, Robin

PY - 2017/3

Y1 - 2017/3

N2 - Inositol and inositol-containing compounds have signalling and regulatory roles in many cellular processes, suggesting that inositol imbalance may lead to wide-ranging changes in cellular functions. Indeed, changes in inositol-dependent signalling have been implicated in various diseases and cellular functions such as autophagy, and these changes have often been proposed as therapeutic targets. However, few studies have highlighted the links between inositol depletion and the downstream effects on inositol phosphates and phosphoinositides in disease states. For this research, many advances have employed simple model systems that include the social amoeba D. discoideum and the yeast S. cerevisiae, since these models enable a range of experimental approaches that are not possible in mammalian models. In this review, we discuss recent findings initiated in simple model systems and translated to higher model organisms where the effect of altered inositol, inositol phosphate and phosphoinositide levels impact on bipolar disorder, Alzheimer disease, epilepsy and autophagy.

AB - Inositol and inositol-containing compounds have signalling and regulatory roles in many cellular processes, suggesting that inositol imbalance may lead to wide-ranging changes in cellular functions. Indeed, changes in inositol-dependent signalling have been implicated in various diseases and cellular functions such as autophagy, and these changes have often been proposed as therapeutic targets. However, few studies have highlighted the links between inositol depletion and the downstream effects on inositol phosphates and phosphoinositides in disease states. For this research, many advances have employed simple model systems that include the social amoeba D. discoideum and the yeast S. cerevisiae, since these models enable a range of experimental approaches that are not possible in mammalian models. In this review, we discuss recent findings initiated in simple model systems and translated to higher model organisms where the effect of altered inositol, inositol phosphate and phosphoinositide levels impact on bipolar disorder, Alzheimer disease, epilepsy and autophagy.

U2 - 10.1016/j.ejcb.2017.01.007

DO - 10.1016/j.ejcb.2017.01.007

M3 - Literature review

VL - 96

SP - 154

EP - 163

JO - EUROPEAN JOURNAL OF CELL BIOLOGY

JF - EUROPEAN JOURNAL OF CELL BIOLOGY

SN - 0171-9335

IS - 2

ER -