The meaning of intragenomic conflict. / Gardner, Andy; Úbeda, Francisco.

In: Nature Ecology & Evolution, Vol. 1, 06.11.2017, p. 1807-1815.

Research output: Contribution to journalArticle

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The meaning of intragenomic conflict. / Gardner, Andy; Úbeda, Francisco.

In: Nature Ecology & Evolution, Vol. 1, 06.11.2017, p. 1807-1815.

Research output: Contribution to journalArticle

Harvard

Gardner, A & Úbeda, F 2017, 'The meaning of intragenomic conflict', Nature Ecology & Evolution, vol. 1, pp. 1807-1815. https://doi.org/10.1038/s41559-017-0354-9

APA

Gardner, A., & Úbeda, F. (2017). The meaning of intragenomic conflict. Nature Ecology & Evolution, 1, 1807-1815. https://doi.org/10.1038/s41559-017-0354-9

Vancouver

Gardner A, Úbeda F. The meaning of intragenomic conflict. Nature Ecology & Evolution. 2017 Nov 6;1:1807-1815. https://doi.org/10.1038/s41559-017-0354-9

Author

Gardner, Andy ; Úbeda, Francisco. / The meaning of intragenomic conflict. In: Nature Ecology & Evolution. 2017 ; Vol. 1. pp. 1807-1815.

BibTeX

@article{5be2efdaba7c4f9892d88ceae698e738,
title = "The meaning of intragenomic conflict",
abstract = "Recent years have seen an explosion of interest in genes that function for their own good and to the detriment of other genes residing in the same genome. Such intragenomic conflicts are increasingly recognised to underpin maladaptation and disease. However, progress has been impeded by a lack of clear understanding as to what intragenomic conflict actually means, and an associated obscurity concerning its fundamental drivers. We develop a general theory of intragenomic conflict in which genes are viewed as inclusive-fitness-maximizing agents that come into conflict when their inclusive-fitness interests disagree. This yields a classification of all intragenomic conflicts into three categories according to whether genes disagree about where they have come from, where they are going, or where they currently are. We illustrate each of these three basic categories, survey and classify all known forms of intragenomic conflict, and discuss the implications for organismal maladaptation and human disease.",
author = "Andy Gardner and Francisco {\'U}beda",
year = "2017",
month = nov,
day = "6",
doi = "10.1038/s41559-017-0354-9",
language = "English",
volume = "1",
pages = "1807--1815",
journal = "Nature Ecology & Evolution",
issn = "2397-334X",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - The meaning of intragenomic conflict

AU - Gardner, Andy

AU - Úbeda, Francisco

PY - 2017/11/6

Y1 - 2017/11/6

N2 - Recent years have seen an explosion of interest in genes that function for their own good and to the detriment of other genes residing in the same genome. Such intragenomic conflicts are increasingly recognised to underpin maladaptation and disease. However, progress has been impeded by a lack of clear understanding as to what intragenomic conflict actually means, and an associated obscurity concerning its fundamental drivers. We develop a general theory of intragenomic conflict in which genes are viewed as inclusive-fitness-maximizing agents that come into conflict when their inclusive-fitness interests disagree. This yields a classification of all intragenomic conflicts into three categories according to whether genes disagree about where they have come from, where they are going, or where they currently are. We illustrate each of these three basic categories, survey and classify all known forms of intragenomic conflict, and discuss the implications for organismal maladaptation and human disease.

AB - Recent years have seen an explosion of interest in genes that function for their own good and to the detriment of other genes residing in the same genome. Such intragenomic conflicts are increasingly recognised to underpin maladaptation and disease. However, progress has been impeded by a lack of clear understanding as to what intragenomic conflict actually means, and an associated obscurity concerning its fundamental drivers. We develop a general theory of intragenomic conflict in which genes are viewed as inclusive-fitness-maximizing agents that come into conflict when their inclusive-fitness interests disagree. This yields a classification of all intragenomic conflicts into three categories according to whether genes disagree about where they have come from, where they are going, or where they currently are. We illustrate each of these three basic categories, survey and classify all known forms of intragenomic conflict, and discuss the implications for organismal maladaptation and human disease.

U2 - 10.1038/s41559-017-0354-9

DO - 10.1038/s41559-017-0354-9

M3 - Article

VL - 1

SP - 1807

EP - 1815

JO - Nature Ecology & Evolution

JF - Nature Ecology & Evolution

SN - 2397-334X

ER -