The Human Basolateral Amygdala Is Indispensable for Social Experiential Learning. / Rosenberger, Lisa; Eisenegger, Christoph; Naef, Michael; Terburg, David; Fourie, Jorique; Stein, Dan J.; van Honk, Jack.

In: Current Biology , Vol. 29, No. 20, 21.10.2019, p. 3532-3537.

Research output: Contribution to journalArticle

Published

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The Human Basolateral Amygdala Is Indispensable for Social Experiential Learning. / Rosenberger, Lisa; Eisenegger, Christoph; Naef, Michael; Terburg, David; Fourie, Jorique; Stein, Dan J.; van Honk, Jack.

In: Current Biology , Vol. 29, No. 20, 21.10.2019, p. 3532-3537.

Research output: Contribution to journalArticle

Harvard

Rosenberger, L, Eisenegger, C, Naef, M, Terburg, D, Fourie, J, Stein, DJ & van Honk, J 2019, 'The Human Basolateral Amygdala Is Indispensable for Social Experiential Learning', Current Biology , vol. 29, no. 20, pp. 3532-3537. https://doi.org/10.1016/j.cub.2019.08.078

APA

Rosenberger, L., Eisenegger, C., Naef, M., Terburg, D., Fourie, J., Stein, D. J., & van Honk, J. (2019). The Human Basolateral Amygdala Is Indispensable for Social Experiential Learning. Current Biology , 29(20), 3532-3537. https://doi.org/10.1016/j.cub.2019.08.078

Vancouver

Rosenberger L, Eisenegger C, Naef M, Terburg D, Fourie J, Stein DJ et al. The Human Basolateral Amygdala Is Indispensable for Social Experiential Learning. Current Biology . 2019 Oct 21;29(20):3532-3537. https://doi.org/10.1016/j.cub.2019.08.078

Author

Rosenberger, Lisa ; Eisenegger, Christoph ; Naef, Michael ; Terburg, David ; Fourie, Jorique ; Stein, Dan J. ; van Honk, Jack. / The Human Basolateral Amygdala Is Indispensable for Social Experiential Learning. In: Current Biology . 2019 ; Vol. 29, No. 20. pp. 3532-3537.

BibTeX

@article{fe0394fa0d4c4b3e9b3a9133d8663f50,
title = "The Human Basolateral Amygdala Is Indispensable for Social Experiential Learning",
abstract = "Trust and betrayal are central to our social world, and adaptive responses to generous and selfish behavior are crucial to our economic and social well-being [1]. We learn about others{\textquoteright} trustworthiness through trial and error during repeated interactions [2]. By reinforcing and suppressing behavior during positive and negative interactions with conspecifics, rodent research has established a crucial role for the basolateral amygdala (BLA) in social experiential learning [3, 4]. The human BLA has undergone a reorganization with massive expansion relative to other amygdala nuclei [5], and there is no translational research on its role in experiential learning. The human amygdala is traditionally researched as a single structure [6], neglecting the sub-nuclei{\textquoteright}s structural und functional differences [7], which might explain inconsistent findings in research on social interactions [8, 9]. Here, we study whether the human BLA is necessary for social and non-social experiential learning by testing a group of five humans with selective bilateral damage to the BLA. We compared their learning behavior in a repeated trust game, and a non-social control task, to healthy, matched controls. Crucially, BLA-damaged subjects, unlike control subjects, completely failed to adapt their investments when interacting with a trustworthy and an untrustworthy partner. In the non-social task, BLA-damaged subjects learned from positive outcomes but differed from the controls by not learning from negative outcomes. Our data extend findings in rodent research by showing that the human BLA is essential for social experiential learning and provide confirmatory evidence of divergent mechanisms for differentially valenced outcomes in non-social learning.",
keywords = "Basolateral amygdala, Trust, Trust game, Social learning, Decision Making, Urbach-Wiethe disease, Brain lesion, Neuroimaging, Neuroeconomics",
author = "Lisa Rosenberger and Christoph Eisenegger and Michael Naef and David Terburg and Jorique Fourie and Stein, {Dan J.} and {van Honk}, Jack",
year = "2019",
month = oct,
day = "21",
doi = "10.1016/j.cub.2019.08.078",
language = "English",
volume = "29",
pages = "3532--3537",
journal = "Current Biology ",
issn = "0960-9822",
publisher = "Cell Press",
number = "20",

}

RIS

TY - JOUR

T1 - The Human Basolateral Amygdala Is Indispensable for Social Experiential Learning

AU - Rosenberger, Lisa

AU - Eisenegger, Christoph

AU - Naef, Michael

AU - Terburg, David

AU - Fourie, Jorique

AU - Stein, Dan J.

AU - van Honk, Jack

PY - 2019/10/21

Y1 - 2019/10/21

N2 - Trust and betrayal are central to our social world, and adaptive responses to generous and selfish behavior are crucial to our economic and social well-being [1]. We learn about others’ trustworthiness through trial and error during repeated interactions [2]. By reinforcing and suppressing behavior during positive and negative interactions with conspecifics, rodent research has established a crucial role for the basolateral amygdala (BLA) in social experiential learning [3, 4]. The human BLA has undergone a reorganization with massive expansion relative to other amygdala nuclei [5], and there is no translational research on its role in experiential learning. The human amygdala is traditionally researched as a single structure [6], neglecting the sub-nuclei’s structural und functional differences [7], which might explain inconsistent findings in research on social interactions [8, 9]. Here, we study whether the human BLA is necessary for social and non-social experiential learning by testing a group of five humans with selective bilateral damage to the BLA. We compared their learning behavior in a repeated trust game, and a non-social control task, to healthy, matched controls. Crucially, BLA-damaged subjects, unlike control subjects, completely failed to adapt their investments when interacting with a trustworthy and an untrustworthy partner. In the non-social task, BLA-damaged subjects learned from positive outcomes but differed from the controls by not learning from negative outcomes. Our data extend findings in rodent research by showing that the human BLA is essential for social experiential learning and provide confirmatory evidence of divergent mechanisms for differentially valenced outcomes in non-social learning.

AB - Trust and betrayal are central to our social world, and adaptive responses to generous and selfish behavior are crucial to our economic and social well-being [1]. We learn about others’ trustworthiness through trial and error during repeated interactions [2]. By reinforcing and suppressing behavior during positive and negative interactions with conspecifics, rodent research has established a crucial role for the basolateral amygdala (BLA) in social experiential learning [3, 4]. The human BLA has undergone a reorganization with massive expansion relative to other amygdala nuclei [5], and there is no translational research on its role in experiential learning. The human amygdala is traditionally researched as a single structure [6], neglecting the sub-nuclei’s structural und functional differences [7], which might explain inconsistent findings in research on social interactions [8, 9]. Here, we study whether the human BLA is necessary for social and non-social experiential learning by testing a group of five humans with selective bilateral damage to the BLA. We compared their learning behavior in a repeated trust game, and a non-social control task, to healthy, matched controls. Crucially, BLA-damaged subjects, unlike control subjects, completely failed to adapt their investments when interacting with a trustworthy and an untrustworthy partner. In the non-social task, BLA-damaged subjects learned from positive outcomes but differed from the controls by not learning from negative outcomes. Our data extend findings in rodent research by showing that the human BLA is essential for social experiential learning and provide confirmatory evidence of divergent mechanisms for differentially valenced outcomes in non-social learning.

KW - Basolateral amygdala

KW - Trust

KW - Trust game

KW - Social learning

KW - Decision Making

KW - Urbach-Wiethe disease

KW - Brain lesion

KW - Neuroimaging

KW - Neuroeconomics

U2 - 10.1016/j.cub.2019.08.078

DO - 10.1016/j.cub.2019.08.078

M3 - Article

VL - 29

SP - 3532

EP - 3537

JO - Current Biology

JF - Current Biology

SN - 0960-9822

IS - 20

ER -