The effects of improving sleep on mental health (OASIS) : a randomised controlled trial with mediation analysis. / Freeman, Daniel; Sheaves, Bryony; Goodwin, Guy M.; Yu, Ly Mee; Nickless, Alecia; Harrison, Paul J.; Emsley, Richard; Luik, Annemarie I.; Foster, Russell G.; Wadekar, Vanashree; Hinds, Christopher; Gumley, Andrew; Jones, Ray; Lightman, Stafford; Jones, Steve; Bentall, Richard; Kinderman, Peter; Rowse, Georgina; Brugha, Traolach; Blagrove, Mark; Gregory, Alice M.; Fleming, Leanne; Walklet, Elaine; Glazebrook, Cris; Davies, E. Bethan; Hollis, Chris; Haddock, Gillian; John, Bev; Coulson, Mark; Fowler, David; Pugh, Katherine; Cape, John; Moseley, Peter; Brown, Gary; Hughes, Claire; Obonsawin, Marc; Coker, Sian; Watkins, Edward; Schwannauer, Matthias; MacMahon, Kenneth; Siriwardena, A. Niroshan; Espie, Colin A.

In: The Lancet Psychiatry, Vol. 4, No. 10, 10.2017, p. 749-758.

Research output: Contribution to journalArticlepeer-review

Published

Standard

The effects of improving sleep on mental health (OASIS) : a randomised controlled trial with mediation analysis. / Freeman, Daniel; Sheaves, Bryony; Goodwin, Guy M.; Yu, Ly Mee; Nickless, Alecia; Harrison, Paul J.; Emsley, Richard; Luik, Annemarie I.; Foster, Russell G.; Wadekar, Vanashree; Hinds, Christopher; Gumley, Andrew; Jones, Ray; Lightman, Stafford; Jones, Steve; Bentall, Richard; Kinderman, Peter; Rowse, Georgina; Brugha, Traolach; Blagrove, Mark; Gregory, Alice M.; Fleming, Leanne; Walklet, Elaine; Glazebrook, Cris; Davies, E. Bethan; Hollis, Chris; Haddock, Gillian; John, Bev; Coulson, Mark; Fowler, David; Pugh, Katherine; Cape, John; Moseley, Peter; Brown, Gary; Hughes, Claire; Obonsawin, Marc; Coker, Sian; Watkins, Edward; Schwannauer, Matthias; MacMahon, Kenneth; Siriwardena, A. Niroshan; Espie, Colin A.

In: The Lancet Psychiatry, Vol. 4, No. 10, 10.2017, p. 749-758.

Research output: Contribution to journalArticlepeer-review

Harvard

Freeman, D, Sheaves, B, Goodwin, GM, Yu, LM, Nickless, A, Harrison, PJ, Emsley, R, Luik, AI, Foster, RG, Wadekar, V, Hinds, C, Gumley, A, Jones, R, Lightman, S, Jones, S, Bentall, R, Kinderman, P, Rowse, G, Brugha, T, Blagrove, M, Gregory, AM, Fleming, L, Walklet, E, Glazebrook, C, Davies, EB, Hollis, C, Haddock, G, John, B, Coulson, M, Fowler, D, Pugh, K, Cape, J, Moseley, P, Brown, G, Hughes, C, Obonsawin, M, Coker, S, Watkins, E, Schwannauer, M, MacMahon, K, Siriwardena, AN & Espie, CA 2017, 'The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis', The Lancet Psychiatry, vol. 4, no. 10, pp. 749-758. https://doi.org/10.1016/S2215-0366(17)30328-0

APA

Freeman, D., Sheaves, B., Goodwin, G. M., Yu, L. M., Nickless, A., Harrison, P. J., Emsley, R., Luik, A. I., Foster, R. G., Wadekar, V., Hinds, C., Gumley, A., Jones, R., Lightman, S., Jones, S., Bentall, R., Kinderman, P., Rowse, G., Brugha, T., ... Espie, C. A. (2017). The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis. The Lancet Psychiatry, 4(10), 749-758. https://doi.org/10.1016/S2215-0366(17)30328-0

Vancouver

Freeman D, Sheaves B, Goodwin GM, Yu LM, Nickless A, Harrison PJ et al. The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis. The Lancet Psychiatry. 2017 Oct;4(10):749-758. https://doi.org/10.1016/S2215-0366(17)30328-0

Author

Freeman, Daniel ; Sheaves, Bryony ; Goodwin, Guy M. ; Yu, Ly Mee ; Nickless, Alecia ; Harrison, Paul J. ; Emsley, Richard ; Luik, Annemarie I. ; Foster, Russell G. ; Wadekar, Vanashree ; Hinds, Christopher ; Gumley, Andrew ; Jones, Ray ; Lightman, Stafford ; Jones, Steve ; Bentall, Richard ; Kinderman, Peter ; Rowse, Georgina ; Brugha, Traolach ; Blagrove, Mark ; Gregory, Alice M. ; Fleming, Leanne ; Walklet, Elaine ; Glazebrook, Cris ; Davies, E. Bethan ; Hollis, Chris ; Haddock, Gillian ; John, Bev ; Coulson, Mark ; Fowler, David ; Pugh, Katherine ; Cape, John ; Moseley, Peter ; Brown, Gary ; Hughes, Claire ; Obonsawin, Marc ; Coker, Sian ; Watkins, Edward ; Schwannauer, Matthias ; MacMahon, Kenneth ; Siriwardena, A. Niroshan ; Espie, Colin A. / The effects of improving sleep on mental health (OASIS) : a randomised controlled trial with mediation analysis. In: The Lancet Psychiatry. 2017 ; Vol. 4, No. 10. pp. 749-758.

BibTeX

@article{0ad76de5e341448085346041d770690e,
title = "The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis",
abstract = "Background: Sleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads to a reduction in paranoia and hallucinations. Methods: We did this single-blind, randomised controlled trial (OASIS) at 26 UK universities. University students with insomnia were randomly assigned (1:1) with simple randomisation to receive digital cognitive behavioural therapy (CBT) for insomnia or usual care, and the research team were masked to the treatment. Online assessments took place at weeks 0, 3, 10 (end of therapy), and 22. The primary outcome measures were for insomnia, paranoia, and hallucinatory experiences. We did intention-to-treat analyses. The trial is registered with the ISRCTN registry, number ISRCTN61272251. Findings: Between March 5, 2015, and Feb 17, 2016, we randomly assigned 3755 participants to receive digital CBT for insomnia (n=1891) or usual practice (n=1864). Compared with usual practice, the sleep intervention at 10 weeks reduced insomnia (adjusted difference 4·78, 95% CI 4·29 to 5·26, Cohen's d=1·11; p<0·0001), paranoia (−2·22, −2·98 to −1·45, Cohen's d=0·19; p<0·0001), and hallucinations (−1·58, −1·98 to −1·18, Cohen's d=0·24; p<0·0001). Insomnia was a mediator of change in paranoia and hallucinations. No adverse events were reported. Interpretation: To our knowledge, this is the largest randomised controlled trial of a psychological intervention for a mental health problem. It provides strong evidence that insomnia is a causal factor in the occurrence of psychotic experiences and other mental health problems. Whether the results generalise beyond a student population requires testing. The treatment of disrupted sleep might require a higher priority in mental health provision. Funding: Wellcome Trust.",
author = "Daniel Freeman and Bryony Sheaves and Goodwin, {Guy M.} and Yu, {Ly Mee} and Alecia Nickless and Harrison, {Paul J.} and Richard Emsley and Luik, {Annemarie I.} and Foster, {Russell G.} and Vanashree Wadekar and Christopher Hinds and Andrew Gumley and Ray Jones and Stafford Lightman and Steve Jones and Richard Bentall and Peter Kinderman and Georgina Rowse and Traolach Brugha and Mark Blagrove and Gregory, {Alice M.} and Leanne Fleming and Elaine Walklet and Cris Glazebrook and Davies, {E. Bethan} and Chris Hollis and Gillian Haddock and Bev John and Mark Coulson and David Fowler and Katherine Pugh and John Cape and Peter Moseley and Gary Brown and Claire Hughes and Marc Obonsawin and Sian Coker and Edward Watkins and Matthias Schwannauer and Kenneth MacMahon and Siriwardena, {A. Niroshan} and Espie, {Colin A.}",
year = "2017",
month = oct,
doi = "10.1016/S2215-0366(17)30328-0",
language = "English",
volume = "4",
pages = "749--758",
journal = "The Lancet Psychiatry",
issn = "2215-0366",
publisher = "Elsevier Limited",
number = "10",

}

RIS

TY - JOUR

T1 - The effects of improving sleep on mental health (OASIS)

T2 - a randomised controlled trial with mediation analysis

AU - Freeman, Daniel

AU - Sheaves, Bryony

AU - Goodwin, Guy M.

AU - Yu, Ly Mee

AU - Nickless, Alecia

AU - Harrison, Paul J.

AU - Emsley, Richard

AU - Luik, Annemarie I.

AU - Foster, Russell G.

AU - Wadekar, Vanashree

AU - Hinds, Christopher

AU - Gumley, Andrew

AU - Jones, Ray

AU - Lightman, Stafford

AU - Jones, Steve

AU - Bentall, Richard

AU - Kinderman, Peter

AU - Rowse, Georgina

AU - Brugha, Traolach

AU - Blagrove, Mark

AU - Gregory, Alice M.

AU - Fleming, Leanne

AU - Walklet, Elaine

AU - Glazebrook, Cris

AU - Davies, E. Bethan

AU - Hollis, Chris

AU - Haddock, Gillian

AU - John, Bev

AU - Coulson, Mark

AU - Fowler, David

AU - Pugh, Katherine

AU - Cape, John

AU - Moseley, Peter

AU - Brown, Gary

AU - Hughes, Claire

AU - Obonsawin, Marc

AU - Coker, Sian

AU - Watkins, Edward

AU - Schwannauer, Matthias

AU - MacMahon, Kenneth

AU - Siriwardena, A. Niroshan

AU - Espie, Colin A.

PY - 2017/10

Y1 - 2017/10

N2 - Background: Sleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads to a reduction in paranoia and hallucinations. Methods: We did this single-blind, randomised controlled trial (OASIS) at 26 UK universities. University students with insomnia were randomly assigned (1:1) with simple randomisation to receive digital cognitive behavioural therapy (CBT) for insomnia or usual care, and the research team were masked to the treatment. Online assessments took place at weeks 0, 3, 10 (end of therapy), and 22. The primary outcome measures were for insomnia, paranoia, and hallucinatory experiences. We did intention-to-treat analyses. The trial is registered with the ISRCTN registry, number ISRCTN61272251. Findings: Between March 5, 2015, and Feb 17, 2016, we randomly assigned 3755 participants to receive digital CBT for insomnia (n=1891) or usual practice (n=1864). Compared with usual practice, the sleep intervention at 10 weeks reduced insomnia (adjusted difference 4·78, 95% CI 4·29 to 5·26, Cohen's d=1·11; p<0·0001), paranoia (−2·22, −2·98 to −1·45, Cohen's d=0·19; p<0·0001), and hallucinations (−1·58, −1·98 to −1·18, Cohen's d=0·24; p<0·0001). Insomnia was a mediator of change in paranoia and hallucinations. No adverse events were reported. Interpretation: To our knowledge, this is the largest randomised controlled trial of a psychological intervention for a mental health problem. It provides strong evidence that insomnia is a causal factor in the occurrence of psychotic experiences and other mental health problems. Whether the results generalise beyond a student population requires testing. The treatment of disrupted sleep might require a higher priority in mental health provision. Funding: Wellcome Trust.

AB - Background: Sleep difficulties might be a contributory causal factor in the occurrence of mental health problems. If this is true, improving sleep should benefit psychological health. We aimed to determine whether treating insomnia leads to a reduction in paranoia and hallucinations. Methods: We did this single-blind, randomised controlled trial (OASIS) at 26 UK universities. University students with insomnia were randomly assigned (1:1) with simple randomisation to receive digital cognitive behavioural therapy (CBT) for insomnia or usual care, and the research team were masked to the treatment. Online assessments took place at weeks 0, 3, 10 (end of therapy), and 22. The primary outcome measures were for insomnia, paranoia, and hallucinatory experiences. We did intention-to-treat analyses. The trial is registered with the ISRCTN registry, number ISRCTN61272251. Findings: Between March 5, 2015, and Feb 17, 2016, we randomly assigned 3755 participants to receive digital CBT for insomnia (n=1891) or usual practice (n=1864). Compared with usual practice, the sleep intervention at 10 weeks reduced insomnia (adjusted difference 4·78, 95% CI 4·29 to 5·26, Cohen's d=1·11; p<0·0001), paranoia (−2·22, −2·98 to −1·45, Cohen's d=0·19; p<0·0001), and hallucinations (−1·58, −1·98 to −1·18, Cohen's d=0·24; p<0·0001). Insomnia was a mediator of change in paranoia and hallucinations. No adverse events were reported. Interpretation: To our knowledge, this is the largest randomised controlled trial of a psychological intervention for a mental health problem. It provides strong evidence that insomnia is a causal factor in the occurrence of psychotic experiences and other mental health problems. Whether the results generalise beyond a student population requires testing. The treatment of disrupted sleep might require a higher priority in mental health provision. Funding: Wellcome Trust.

U2 - 10.1016/S2215-0366(17)30328-0

DO - 10.1016/S2215-0366(17)30328-0

M3 - Article

VL - 4

SP - 749

EP - 758

JO - The Lancet Psychiatry

JF - The Lancet Psychiatry

SN - 2215-0366

IS - 10

ER -