Non-invasive early detection and stratification of breast cancer. / Alsaidi, Yasmine; Milnthorpe, Andrew; Soloviev, Mikhail.

2016. Poster session presented at Biosensors 2016, 26th Anniversary World Congress on Biosensors, Post Congress Symposium in Cancer Diagnostics., Gothenburg, Sweden.

Research output: Contribution to conferencePoster

Published

Abstract

Despite the abundance of molecular data, including the existence of many hundreds of potentials protein biomarkers, assessing cellular and histopathological appearance of the tumour remains the main tool for classification of breast cancers. Recently devised molecular classification system considers both receptor status and grade of the tumours, it aids the prognosis and helps in identifying the most suitable therapies. However, despite years of research no suitable molecular tests were developed for the early non-invasive diagnostics of the disease.
We have analysed biological availability and proteolysis stability of the breast cancer associated proteome and selected a subset of 51 subtype specific biomarkers and 39 other disease associated proteins. We have devised a number of affinity assay formats including lateral flow, micro-well plate and microarray-based formats. Our aim is to develop affinity based tests suitable for the point-of-care applications for the early detection, stratification and monitoring of breast cancer.
Original languageEnglish
Publication statusPublished - 28 May 2016
EventBiosensors 2016, 26th Anniversary World Congress on Biosensors, Post Congress Symposium in Cancer Diagnostics. - Gothenburg, Sweden
Duration: 28 May 2016 → …

Conference

ConferenceBiosensors 2016, 26th Anniversary World Congress on Biosensors, Post Congress Symposium in Cancer Diagnostics.
CountrySweden
CityGothenburg
Period28/05/16 → …

ID: 26887154