Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator. / Manfredini, Fabio; Romero Lopez, Alfonso; Pedroso Rovira, Inti; Paccanaro, Alberto; Sumner, Seirian; Brown, Mark.

In: Genome Biology and Evolution, Vol. 9, No. 11, 01.11.2017, p. 3059-3072.

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Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator. / Manfredini, Fabio; Romero Lopez, Alfonso; Pedroso Rovira, Inti; Paccanaro, Alberto; Sumner, Seirian; Brown, Mark.

In: Genome Biology and Evolution, Vol. 9, No. 11, 01.11.2017, p. 3059-3072.

Research output: Contribution to journalArticle

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@article{9b9c793d24d54ee2a4d8a78330ee4f4a,
title = "Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator",
abstract = "Life-history transitions require major reprogramming at the behavioural and physiological level. Mating and reproductive maturation are known to trigger changes in gene transcription in reproductive tissues in a wide range of organisms, but we understand little about the molecular consequences of a failure to mate or become reproductively mature, and it is not clear to what extent these processes trigger neural as well as physiological changes. In this study we examined the molecular processes underpinning the behavioural changes that accompany the major life-history transitions in a key pollinator, the bumblebee Bombus terrestris. We compared neuro-transcription in queens that succeeded or failed in switching from virgin and immature states, to mated and reproductively mature states. Both successes and failures were associated with distinct molecular profiles, illustrating how development during adulthood triggers distinct molecular profiles within a single caste of a eusocial insect. Failures in both mating and reproductive maturation were explained by a general up-regulation of brain gene transcription. We identified 21 genes that were highly connected in a gene co-expression network analysis: 9 genes are involved in neural processes and 4 are regulators of gene expression. This suggests that negotiating life-history transitions involves significant neural processing and reprogramming, and not just changes in physiology. These findings provide novel insights into basic life-history transitions of an insect. Failure to mate or to become reproductively mature is an overlooked component of variation in natural systems, despite its prevalence in many sexually reproducing organisms, and deserves deeper investigation in the future.",
author = "Fabio Manfredini and {Romero Lopez}, Alfonso and {Pedroso Rovira}, Inti and Alberto Paccanaro and Seirian Sumner and Mark Brown",
year = "2017",
month = "11",
day = "1",
doi = "10.1093/gbe/evx220",
language = "English",
volume = "9",
pages = "3059--3072",
journal = "Genome Biology and Evolution",
issn = "1759-6653",
publisher = "Oxford University Press",
number = "11",

}

RIS

TY - JOUR

T1 - Neurogenomic Signatures of Successes and Failures in Life-History Transitions in a Key Insect Pollinator

AU - Manfredini, Fabio

AU - Romero Lopez, Alfonso

AU - Pedroso Rovira, Inti

AU - Paccanaro, Alberto

AU - Sumner, Seirian

AU - Brown, Mark

PY - 2017/11/1

Y1 - 2017/11/1

N2 - Life-history transitions require major reprogramming at the behavioural and physiological level. Mating and reproductive maturation are known to trigger changes in gene transcription in reproductive tissues in a wide range of organisms, but we understand little about the molecular consequences of a failure to mate or become reproductively mature, and it is not clear to what extent these processes trigger neural as well as physiological changes. In this study we examined the molecular processes underpinning the behavioural changes that accompany the major life-history transitions in a key pollinator, the bumblebee Bombus terrestris. We compared neuro-transcription in queens that succeeded or failed in switching from virgin and immature states, to mated and reproductively mature states. Both successes and failures were associated with distinct molecular profiles, illustrating how development during adulthood triggers distinct molecular profiles within a single caste of a eusocial insect. Failures in both mating and reproductive maturation were explained by a general up-regulation of brain gene transcription. We identified 21 genes that were highly connected in a gene co-expression network analysis: 9 genes are involved in neural processes and 4 are regulators of gene expression. This suggests that negotiating life-history transitions involves significant neural processing and reprogramming, and not just changes in physiology. These findings provide novel insights into basic life-history transitions of an insect. Failure to mate or to become reproductively mature is an overlooked component of variation in natural systems, despite its prevalence in many sexually reproducing organisms, and deserves deeper investigation in the future.

AB - Life-history transitions require major reprogramming at the behavioural and physiological level. Mating and reproductive maturation are known to trigger changes in gene transcription in reproductive tissues in a wide range of organisms, but we understand little about the molecular consequences of a failure to mate or become reproductively mature, and it is not clear to what extent these processes trigger neural as well as physiological changes. In this study we examined the molecular processes underpinning the behavioural changes that accompany the major life-history transitions in a key pollinator, the bumblebee Bombus terrestris. We compared neuro-transcription in queens that succeeded or failed in switching from virgin and immature states, to mated and reproductively mature states. Both successes and failures were associated with distinct molecular profiles, illustrating how development during adulthood triggers distinct molecular profiles within a single caste of a eusocial insect. Failures in both mating and reproductive maturation were explained by a general up-regulation of brain gene transcription. We identified 21 genes that were highly connected in a gene co-expression network analysis: 9 genes are involved in neural processes and 4 are regulators of gene expression. This suggests that negotiating life-history transitions involves significant neural processing and reprogramming, and not just changes in physiology. These findings provide novel insights into basic life-history transitions of an insect. Failure to mate or to become reproductively mature is an overlooked component of variation in natural systems, despite its prevalence in many sexually reproducing organisms, and deserves deeper investigation in the future.

U2 - 10.1093/gbe/evx220

DO - 10.1093/gbe/evx220

M3 - Article

VL - 9

SP - 3059

EP - 3072

JO - Genome Biology and Evolution

JF - Genome Biology and Evolution

SN - 1759-6653

IS - 11

ER -