Neurochemical correlates of scene processing in the precuneus/posterior cingulate cortex : A multimodal fMRI and 1H-MRS study. / Costigan, Alison G; Umla-Runge, Katja; Evans, C John; Hodgetts, Carl J; Lawrence, Andrew D; Graham, Kim S.

In: Human Brain Mapping, Vol. 40, No. 10, 07.2019, p. 2884-2898.

Research output: Contribution to journalArticle

Published
  • Alison G Costigan
  • Katja Umla-Runge
  • C John Evans
  • Carl J Hodgetts
  • Andrew D Lawrence
  • Kim S Graham

Abstract

Precuneus/posterior cingulate cortex (PCu/PCC) are key components of a midline network, activated during rest but also in tasks that involve construction of scene or situation models. Despite growing interest in PCu/PCC functional alterations in disease and disease risk, the underlying neurochemical modulators of PCu/PCC's task-evoked activity are largely unstudied. Here, a multimodal imaging approach was applied to investigate whether interindividual differences in PCu/PCC fMRI activity, elicited during perceptual discrimination of scene stimuli, were correlated with local brain metabolite levels, measured during resting-state 1 H-MRS. Forty healthy young adult participants completed an fMRI perceptual odd-one-out task for scenes, objects and faces. 1 H-MRS metabolites N-acetyl-aspartate (tNAA), glutamate (Glx) and γ-amino-butyric acid (GABA+) were quantified via PRESS and MEGA-PRESS scans in a PCu/PCC voxel and an occipital (OCC) control voxel. Whole brain fMRI revealed a cluster in right dorsal PCu/PCC that showed a greater BOLD response to scenes versus faces and objects. When extracted from an independently defined PCu/PCC region of interest, scene activity (vs. faces and objects and also vs. baseline) was positively correlated with PCu/PCC, but not OCC, tNAA. A voxel-wise regression analysis restricted to the PCu/PCC 1 H-MRS voxel area identified a significant PCu/PCC cluster, confirming the positive correlation between scene-related BOLD activity and PCu/PCC tNAA. There were no correlations between PCu/PCC activity and Glx or GABA+ levels. These results demonstrate, for the first time, that scene activity in PCu/PCC is linked to local tNAA levels, identifying a neurochemical influence on interindividual differences in the task-driven activity of a key brain hub.

Original languageEnglish
Pages (from-to)2884-2898
Number of pages15
JournalHuman Brain Mapping
Volume40
Issue number10
Early online date13 Mar 2019
DOIs
Publication statusPublished - Jul 2019
This open access research output is licenced under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.

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