Loss of a prolyl oligopeptidase confers resistance to lithium by elevation of inositol (1,4,5) trisphosphate

R S B Williams, M Eames, W J Ryves, J Viggars, A J Harwood

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)2734-2745
Number of pages12
JournalEMBO Journal
Volume18
Issue number10
Publication statusPublished - 17 May 1999

Keywords

  • clinical depression
  • Discyostelium discoideum
  • inositol triphosphate signalling
  • lithium sensitivity
  • prolyl oligopeptidase
  • GLYCOGEN-SYNTHASE KINASE-3
  • PROLINE-SPECIFIC PEPTIDASES
  • PHOSPHOLIPASE-C ACTIVITY
  • DICTYOSTELIUM-DISCOIDEUM
  • MOLECULAR-CLONING
  • 1,4,5-TRISPHOSPHATE FORMATION
  • ENDOPLASMIC-RETICULUM
  • CELL-DIFFERENTIATION
  • GENE-EXPRESSION
  • CLEAVING ENZYME

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