Impacts of undetected and inadequately treated hypertension on incident stroke in China. / Han, Thang ; Wang, Harry ; Wei, Li ; Pan, Yuesong ; Ying Ma, Ying Ma; Wang, Yu ; Wang, Jiaji ; Hu, Zhi ; Sharma, Pankaj; Chen, Ruoling .

In: BMJ Open, Vol. 7, No. 10, e016581, 08.10.2017, p. 1-9.

Research output: Contribution to journalArticle

E-pub ahead of print

Documents

  • Thang Han
  • Harry Wang
  • Li Wei
  • Yuesong Pan
  • Ying Ma Ying Ma
  • Yu Wang
  • Jiaji Wang
  • Zhi Hu
  • Pankaj Sharma
  • Ruoling Chen

Abstract

Objectives
China carries the greatest burden of stroke given its largest volume of people with hypertension. This study assessed the impacts of suboptimal controls of hypertension on incident stroke and projected the number of patients with stroke saved after the control of blood pressure improved in population.

Setting
Anhui, China.

Participants
We examined data from the Anhui cohort of 2001–2011, consisting of 3336 participants aged ≥60 years who were randomly recruited from the urban and rural Anhui. 2852 participants (89.2%) had hypertensive status measured and no stroke at baseline, and were followed up until 2011 in three surveys using a standard method of interview.

Results
At baseline, 1646 participants (57.7%) were identified to have hypertension, among whom 912 (55.4%) were previously undetected, 115 (7.0%) detected but not treated, 452 (27.5%) treated but not controlled and only 127 (7.7%) controlled. During the 10-year follow-up, 211 incident stroke cases (12.8/1000 person-years) occurred. Compared with normotensive individuals at baseline, multivariate adjusted HR for having stroke increased in those with undetected hypertension by 1.63 (95%CI 1.15 to 2.32), untreated by 2.21 (1.26–3.85) and uncontrolled hypertension by 3.34 (2.28–4.88), but did not differ from those with controlled hypertension (1.34; 0.60–2.99). Based on a two-fold increase in the detection and management of current levels of hypertension and algorithms on the current situation in China, approximately 250 000 incident stroke cases could be prevented annually.

Conclusions
In China, hypertension is frequently undetected or inadequately treated. With appropriate management of hypertension, a substantial number of people could be saved form stroke.
Original languageEnglish
Article numbere016581
Pages (from-to)1-9
Number of pages9
JournalBMJ Open
Volume7
Issue number10
Early online date8 Oct 2017
DOIs
Publication statusE-pub ahead of print - 8 Oct 2017
This open access research output is licenced under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.

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