Evidencing a place for the hippocampus within the core scene processing network. / Hodgetts, C J; Shine, J P; Lawrence, A D; Downing, P E; Graham, K S.

In: Human Brain Mapping, Vol. 37, No. 11, 11.2016, p. 3779-3794.

Research output: Contribution to journalArticlepeer-review

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Evidencing a place for the hippocampus within the core scene processing network. / Hodgetts, C J; Shine, J P; Lawrence, A D; Downing, P E; Graham, K S.

In: Human Brain Mapping, Vol. 37, No. 11, 11.2016, p. 3779-3794.

Research output: Contribution to journalArticlepeer-review

Harvard

Hodgetts, CJ, Shine, JP, Lawrence, AD, Downing, PE & Graham, KS 2016, 'Evidencing a place for the hippocampus within the core scene processing network', Human Brain Mapping, vol. 37, no. 11, pp. 3779-3794. https://doi.org/10.1002/hbm.23275

APA

Hodgetts, C. J., Shine, J. P., Lawrence, A. D., Downing, P. E., & Graham, K. S. (2016). Evidencing a place for the hippocampus within the core scene processing network. Human Brain Mapping, 37(11), 3779-3794. https://doi.org/10.1002/hbm.23275

Vancouver

Hodgetts CJ, Shine JP, Lawrence AD, Downing PE, Graham KS. Evidencing a place for the hippocampus within the core scene processing network. Human Brain Mapping. 2016 Nov;37(11):3779-3794. https://doi.org/10.1002/hbm.23275

Author

Hodgetts, C J ; Shine, J P ; Lawrence, A D ; Downing, P E ; Graham, K S. / Evidencing a place for the hippocampus within the core scene processing network. In: Human Brain Mapping. 2016 ; Vol. 37, No. 11. pp. 3779-3794.

BibTeX

@article{0b5d449128584c33bcf4caf2db64c861,
title = "Evidencing a place for the hippocampus within the core scene processing network",
abstract = "Functional neuroimaging studies have identified several {"}core{"} brain regions that are preferentially activated by scene stimuli, namely posterior parahippocampal gyrus (PHG), retrosplenial cortex (RSC), and transverse occipital sulcus (TOS). The hippocampus (HC), too, is thought to play a key role in scene processing, although no study has yet investigated scene-sensitivity in the HC relative to these other {"}core{"} regions. Here, we characterised the frequency and consistency of individual scene-preferential responses within these regions by analysing a large dataset (n = 51) in which participants performed a one-back working memory task for scenes, objects, and scrambled objects. An unbiased approach was adopted by applying independently-defined anatomical ROIs to individual-level functional data across different voxel-wise thresholds and spatial filters. It was found that the majority of subjects had preferential scene clusters in PHG (max = 100% of participants), RSC (max = 76%), and TOS (max = 94%). A comparable number of individuals also possessed significant scene-related clusters within their individually defined HC ROIs (max = 88%), evidencing a HC contribution to scene processing. While probabilistic overlap maps of individual clusters showed that overlap {"}peaks{"} were close to those identified in group-level analyses (particularly for TOS and HC), inter-individual consistency varied across regions and statistical thresholds. The inter-regional and inter-individual variability revealed by these analyses has implications for how scene-sensitive cortex is localised and interrogated in functional neuroimaging studies, particularly in medial temporal lobe regions, such as the HC. Hum Brain Mapp 37:3779-3794, 2016. {\textcopyright} 2016 Wiley Periodicals, Inc.",
keywords = "Adolescent, Adult, Brain Mapping, Cerebral Cortex/diagnostic imaging, Female, Hippocampus/diagnostic imaging, Humans, Magnetic Resonance Imaging, Male, Memory/physiology, Neural Pathways/diagnostic imaging, Neuropsychological Tests, Photic Stimulation, Visual Perception/physiology, Young Adult",
author = "Hodgetts, {C J} and Shine, {J P} and Lawrence, {A D} and Downing, {P E} and Graham, {K S}",
note = "{\textcopyright} 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.",
year = "2016",
month = nov,
doi = "10.1002/hbm.23275",
language = "English",
volume = "37",
pages = "3779--3794",
journal = "Human Brain Mapping",
issn = "1065-9471",
publisher = "Wiley-Liss Inc.",
number = "11",

}

RIS

TY - JOUR

T1 - Evidencing a place for the hippocampus within the core scene processing network

AU - Hodgetts, C J

AU - Shine, J P

AU - Lawrence, A D

AU - Downing, P E

AU - Graham, K S

N1 - © 2016 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

PY - 2016/11

Y1 - 2016/11

N2 - Functional neuroimaging studies have identified several "core" brain regions that are preferentially activated by scene stimuli, namely posterior parahippocampal gyrus (PHG), retrosplenial cortex (RSC), and transverse occipital sulcus (TOS). The hippocampus (HC), too, is thought to play a key role in scene processing, although no study has yet investigated scene-sensitivity in the HC relative to these other "core" regions. Here, we characterised the frequency and consistency of individual scene-preferential responses within these regions by analysing a large dataset (n = 51) in which participants performed a one-back working memory task for scenes, objects, and scrambled objects. An unbiased approach was adopted by applying independently-defined anatomical ROIs to individual-level functional data across different voxel-wise thresholds and spatial filters. It was found that the majority of subjects had preferential scene clusters in PHG (max = 100% of participants), RSC (max = 76%), and TOS (max = 94%). A comparable number of individuals also possessed significant scene-related clusters within their individually defined HC ROIs (max = 88%), evidencing a HC contribution to scene processing. While probabilistic overlap maps of individual clusters showed that overlap "peaks" were close to those identified in group-level analyses (particularly for TOS and HC), inter-individual consistency varied across regions and statistical thresholds. The inter-regional and inter-individual variability revealed by these analyses has implications for how scene-sensitive cortex is localised and interrogated in functional neuroimaging studies, particularly in medial temporal lobe regions, such as the HC. Hum Brain Mapp 37:3779-3794, 2016. © 2016 Wiley Periodicals, Inc.

AB - Functional neuroimaging studies have identified several "core" brain regions that are preferentially activated by scene stimuli, namely posterior parahippocampal gyrus (PHG), retrosplenial cortex (RSC), and transverse occipital sulcus (TOS). The hippocampus (HC), too, is thought to play a key role in scene processing, although no study has yet investigated scene-sensitivity in the HC relative to these other "core" regions. Here, we characterised the frequency and consistency of individual scene-preferential responses within these regions by analysing a large dataset (n = 51) in which participants performed a one-back working memory task for scenes, objects, and scrambled objects. An unbiased approach was adopted by applying independently-defined anatomical ROIs to individual-level functional data across different voxel-wise thresholds and spatial filters. It was found that the majority of subjects had preferential scene clusters in PHG (max = 100% of participants), RSC (max = 76%), and TOS (max = 94%). A comparable number of individuals also possessed significant scene-related clusters within their individually defined HC ROIs (max = 88%), evidencing a HC contribution to scene processing. While probabilistic overlap maps of individual clusters showed that overlap "peaks" were close to those identified in group-level analyses (particularly for TOS and HC), inter-individual consistency varied across regions and statistical thresholds. The inter-regional and inter-individual variability revealed by these analyses has implications for how scene-sensitive cortex is localised and interrogated in functional neuroimaging studies, particularly in medial temporal lobe regions, such as the HC. Hum Brain Mapp 37:3779-3794, 2016. © 2016 Wiley Periodicals, Inc.

KW - Adolescent

KW - Adult

KW - Brain Mapping

KW - Cerebral Cortex/diagnostic imaging

KW - Female

KW - Hippocampus/diagnostic imaging

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory/physiology

KW - Neural Pathways/diagnostic imaging

KW - Neuropsychological Tests

KW - Photic Stimulation

KW - Visual Perception/physiology

KW - Young Adult

U2 - 10.1002/hbm.23275

DO - 10.1002/hbm.23275

M3 - Article

C2 - 27257784

VL - 37

SP - 3779

EP - 3794

JO - Human Brain Mapping

JF - Human Brain Mapping

SN - 1065-9471

IS - 11

ER -