Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory. / Hodgetts, Carl J; Postans, Mark; Warne, Naomi; Varnava, Alice; Lawrence, Andrew D; Graham, Kim S.

In: Cortex, Vol. 94, 09.2017, p. 1-14.

Research output: Contribution to journalArticle

Published

Standard

Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory. / Hodgetts, Carl J; Postans, Mark; Warne, Naomi; Varnava, Alice; Lawrence, Andrew D; Graham, Kim S.

In: Cortex, Vol. 94, 09.2017, p. 1-14.

Research output: Contribution to journalArticle

Harvard

APA

Vancouver

Author

Hodgetts, Carl J ; Postans, Mark ; Warne, Naomi ; Varnava, Alice ; Lawrence, Andrew D ; Graham, Kim S. / Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory. In: Cortex. 2017 ; Vol. 94. pp. 1-14.

BibTeX

@article{4d04d9bbf8124efbb66ebc9368810dbd,
title = "Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory",
abstract = "Autobiographical memory (AM) is multifaceted, incorporating the vivid retrieval of contextual detail (episodic AM), together with semantic knowledge that infuses meaning and coherence into past events (semantic AM). While neuropsychological evidence highlights a role for the hippocampus and anterior temporal lobe (ATL) in episodic and semantic AM, respectively, it is unclear whether these constitute dissociable large-scale AM networks. We used high angular resolution diffusion-weighted imaging and constrained spherical deconvolution-based tractography to assess white matter microstructure in 27 healthy young adult participants who were asked to recall past experiences using word cues. Inter-individual variation in the microstructure of the fornix (the main hippocampal input/output pathway) related to the amount of episodic, but not semantic, detail in AMs - independent of memory age. Conversely, microstructure of the inferior longitudinal fasciculus, linking occipitotemporal regions with ATL, correlated with semantic, but not episodic, AMs. Further, these significant correlations remained when controlling for hippocampal and ATL grey matter volume, respectively. This striking correlational double dissociation supports the view that distinct, large-scale distributed brain circuits underpin context and concepts in AM.",
keywords = "Adolescent, Brain/diagnostic imaging, Brain Mapping, Diffusion Magnetic Resonance Imaging, Female, Fornix, Brain/diagnostic imaging, Gray Matter/diagnostic imaging, Humans, Image Processing, Computer-Assisted, Individuality, Male, Memory, Episodic, Nerve Net/diagnostic imaging, Neuropsychological Tests, Organ Size/physiology, White Matter/diagnostic imaging, Young Adult",
author = "Hodgetts, {Carl J} and Mark Postans and Naomi Warne and Alice Varnava and Lawrence, {Andrew D} and Graham, {Kim S}",
note = "Copyright {\textcopyright} 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.",
year = "2017",
month = sep,
doi = "10.1016/j.cortex.2017.05.010",
language = "English",
volume = "94",
pages = "1--14",
journal = "Cortex",
issn = "0010-9452",
publisher = "Masson SpA",

}

RIS

TY - JOUR

T1 - Distinct contributions of the fornix and inferior longitudinal fasciculus to episodic and semantic autobiographical memory

AU - Hodgetts, Carl J

AU - Postans, Mark

AU - Warne, Naomi

AU - Varnava, Alice

AU - Lawrence, Andrew D

AU - Graham, Kim S

N1 - Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

PY - 2017/9

Y1 - 2017/9

N2 - Autobiographical memory (AM) is multifaceted, incorporating the vivid retrieval of contextual detail (episodic AM), together with semantic knowledge that infuses meaning and coherence into past events (semantic AM). While neuropsychological evidence highlights a role for the hippocampus and anterior temporal lobe (ATL) in episodic and semantic AM, respectively, it is unclear whether these constitute dissociable large-scale AM networks. We used high angular resolution diffusion-weighted imaging and constrained spherical deconvolution-based tractography to assess white matter microstructure in 27 healthy young adult participants who were asked to recall past experiences using word cues. Inter-individual variation in the microstructure of the fornix (the main hippocampal input/output pathway) related to the amount of episodic, but not semantic, detail in AMs - independent of memory age. Conversely, microstructure of the inferior longitudinal fasciculus, linking occipitotemporal regions with ATL, correlated with semantic, but not episodic, AMs. Further, these significant correlations remained when controlling for hippocampal and ATL grey matter volume, respectively. This striking correlational double dissociation supports the view that distinct, large-scale distributed brain circuits underpin context and concepts in AM.

AB - Autobiographical memory (AM) is multifaceted, incorporating the vivid retrieval of contextual detail (episodic AM), together with semantic knowledge that infuses meaning and coherence into past events (semantic AM). While neuropsychological evidence highlights a role for the hippocampus and anterior temporal lobe (ATL) in episodic and semantic AM, respectively, it is unclear whether these constitute dissociable large-scale AM networks. We used high angular resolution diffusion-weighted imaging and constrained spherical deconvolution-based tractography to assess white matter microstructure in 27 healthy young adult participants who were asked to recall past experiences using word cues. Inter-individual variation in the microstructure of the fornix (the main hippocampal input/output pathway) related to the amount of episodic, but not semantic, detail in AMs - independent of memory age. Conversely, microstructure of the inferior longitudinal fasciculus, linking occipitotemporal regions with ATL, correlated with semantic, but not episodic, AMs. Further, these significant correlations remained when controlling for hippocampal and ATL grey matter volume, respectively. This striking correlational double dissociation supports the view that distinct, large-scale distributed brain circuits underpin context and concepts in AM.

KW - Adolescent

KW - Brain/diagnostic imaging

KW - Brain Mapping

KW - Diffusion Magnetic Resonance Imaging

KW - Female

KW - Fornix, Brain/diagnostic imaging

KW - Gray Matter/diagnostic imaging

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Individuality

KW - Male

KW - Memory, Episodic

KW - Nerve Net/diagnostic imaging

KW - Neuropsychological Tests

KW - Organ Size/physiology

KW - White Matter/diagnostic imaging

KW - Young Adult

U2 - 10.1016/j.cortex.2017.05.010

DO - 10.1016/j.cortex.2017.05.010

M3 - Article

C2 - 28710907

VL - 94

SP - 1

EP - 14

JO - Cortex

JF - Cortex

SN - 0010-9452

ER -