Cognitive impairment in pediatric-onset multiple sclerosis is detected by the Brief International Cognitive Assessment for Multiple Sclerosis and computerized cognitive testing. / Charvet, Leigh; Shaw, Michael; Frontario, Ariana; Langdon, Dawn; Krupp, Lauren.

In: Multiple Sclerosis, Vol. 24, No. 4, 01.04.2018, p. 512-519.

Research output: Contribution to journalArticlepeer-review



  • Leigh Charvet
  • Michael Shaw
  • Ariana Frontario
  • Dawn Langdon
  • Lauren Krupp


We investigated the contribution of cortical lesions to cognitive impairment in 41 paediatric MS patients. Thirteen (32%) paediatric MS patients were considered as cognitively impaired. T2-hyperintense and T1-hypointense white matter lesion volumes did not differ between cognitively impaired and cognitively preserved MS patients. Cortical lesions number, cortical lesions volume and grey matter volume did not differ between cognitively impaired and cognitively preserved patients, whereas white matter volume was significantly lower in cognitively impaired versus cognitively preserved MS patients (p=0.01). Contrary to adult MS, cortical lesions do not seem to contribute to cognitive impairment in paediatric MS patients, which is likely driven by white matter damage.
Original languageEnglish
Pages (from-to)512-519
Number of pages8
JournalMultiple Sclerosis
Issue number4
Early online date21 Mar 2017
Publication statusPublished - 1 Apr 2018
This open access research output is licenced under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License.

ID: 27862018