Clinical Integration of Fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma. / Boitor, Radu; de Wolf, Coen; Weesie, Frank; Shipp, Dustin; Varma, Sandeep; Veitch, David ; Wernham, Aaron ; Koloydenko, Alexey; Puppels, Gerwin; Nijsten, Tamar; Williams, Hywel C.; Caspers, Peter; Notingher, Ioan.

In: Biomedical Optics Express, Vol. 12, No. 4, 11.03.2021, p. 2015-2026.

Research output: Contribution to journalArticlepeer-review

Published

Standard

Clinical Integration of Fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma. / Boitor, Radu; de Wolf, Coen; Weesie, Frank; Shipp, Dustin; Varma, Sandeep; Veitch, David ; Wernham, Aaron ; Koloydenko, Alexey; Puppels, Gerwin; Nijsten, Tamar; Williams, Hywel C.; Caspers, Peter; Notingher, Ioan.

In: Biomedical Optics Express, Vol. 12, No. 4, 11.03.2021, p. 2015-2026.

Research output: Contribution to journalArticlepeer-review

Harvard

Boitor, R, de Wolf, C, Weesie, F, Shipp, D, Varma, S, Veitch, D, Wernham, A, Koloydenko, A, Puppels, G, Nijsten, T, Williams, HC, Caspers, P & Notingher, I 2021, 'Clinical Integration of Fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma', Biomedical Optics Express, vol. 12, no. 4, pp. 2015-2026. https://doi.org/10.1364/BOE.417896

APA

Boitor, R., de Wolf, C., Weesie, F., Shipp, D., Varma, S., Veitch, D., Wernham, A., Koloydenko, A., Puppels, G., Nijsten, T., Williams, H. C., Caspers, P., & Notingher, I. (2021). Clinical Integration of Fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma. Biomedical Optics Express, 12(4), 2015-2026. https://doi.org/10.1364/BOE.417896

Vancouver

Boitor R, de Wolf C, Weesie F, Shipp D, Varma S, Veitch D et al. Clinical Integration of Fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma. Biomedical Optics Express. 2021 Mar 11;12(4):2015-2026. https://doi.org/10.1364/BOE.417896

Author

Boitor, Radu ; de Wolf, Coen ; Weesie, Frank ; Shipp, Dustin ; Varma, Sandeep ; Veitch, David ; Wernham, Aaron ; Koloydenko, Alexey ; Puppels, Gerwin ; Nijsten, Tamar ; Williams, Hywel C. ; Caspers, Peter ; Notingher, Ioan. / Clinical Integration of Fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma. In: Biomedical Optics Express. 2021 ; Vol. 12, No. 4. pp. 2015-2026.

BibTeX

@article{e7181a954d71412ea61c5b376ec02927,
title = "Clinical Integration of Fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma",
abstract = "The Fast Raman device is a new tool developed as a potential alternative to frozen section histology for margin assessment during Mohs micrographic surgery of basal cell carcinoma(BCC). We describe the integration of the device into the clinical pathway and present the first results after investigating skin specimens excised from the head and neck areas. Tissue analysis was fixed to 30 minutes and covered >95% or the surgical margin (including deep andepidermal margins). The preliminary results of the Fast Raman analysis agreed with histology for 84% of cases: 58 out of 67 BCC-negative and 7 out of 10 BCC-positive layers. The false-positive diagnoses were related to incipient hair follicles or inflammation. For the three discordant layers considered BCC-positive by frozen section histology, it is uncertain whether the disagreements were caused by a failure to detect BCC by the Fast Raman device or byhistology miss-diagnoses caused by tissue processing. The Fast Raman device has the potential to provide important benefits to Mohs surgery byreducing the duration and costs of tissue processing and by decreasing diagnosis subjectivity and inter-user variability. The successful integration in the clinical pathway is an important step towards a larger diagnostic test accuracy study.",
author = "Radu Boitor and {de Wolf}, Coen and Frank Weesie and Dustin Shipp and Sandeep Varma and David Veitch and Aaron Wernham and Alexey Koloydenko and Gerwin Puppels and Tamar Nijsten and Williams, {Hywel C.} and Peter Caspers and Ioan Notingher",
year = "2021",
month = mar,
day = "11",
doi = "10.1364/BOE.417896",
language = "English",
volume = "12",
pages = "2015--2026",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "4",

}

RIS

TY - JOUR

T1 - Clinical Integration of Fast Raman spectroscopy for Mohs micrographic surgery of basal cell carcinoma

AU - Boitor, Radu

AU - de Wolf, Coen

AU - Weesie, Frank

AU - Shipp, Dustin

AU - Varma, Sandeep

AU - Veitch, David

AU - Wernham, Aaron

AU - Koloydenko, Alexey

AU - Puppels, Gerwin

AU - Nijsten, Tamar

AU - Williams, Hywel C.

AU - Caspers, Peter

AU - Notingher, Ioan

PY - 2021/3/11

Y1 - 2021/3/11

N2 - The Fast Raman device is a new tool developed as a potential alternative to frozen section histology for margin assessment during Mohs micrographic surgery of basal cell carcinoma(BCC). We describe the integration of the device into the clinical pathway and present the first results after investigating skin specimens excised from the head and neck areas. Tissue analysis was fixed to 30 minutes and covered >95% or the surgical margin (including deep andepidermal margins). The preliminary results of the Fast Raman analysis agreed with histology for 84% of cases: 58 out of 67 BCC-negative and 7 out of 10 BCC-positive layers. The false-positive diagnoses were related to incipient hair follicles or inflammation. For the three discordant layers considered BCC-positive by frozen section histology, it is uncertain whether the disagreements were caused by a failure to detect BCC by the Fast Raman device or byhistology miss-diagnoses caused by tissue processing. The Fast Raman device has the potential to provide important benefits to Mohs surgery byreducing the duration and costs of tissue processing and by decreasing diagnosis subjectivity and inter-user variability. The successful integration in the clinical pathway is an important step towards a larger diagnostic test accuracy study.

AB - The Fast Raman device is a new tool developed as a potential alternative to frozen section histology for margin assessment during Mohs micrographic surgery of basal cell carcinoma(BCC). We describe the integration of the device into the clinical pathway and present the first results after investigating skin specimens excised from the head and neck areas. Tissue analysis was fixed to 30 minutes and covered >95% or the surgical margin (including deep andepidermal margins). The preliminary results of the Fast Raman analysis agreed with histology for 84% of cases: 58 out of 67 BCC-negative and 7 out of 10 BCC-positive layers. The false-positive diagnoses were related to incipient hair follicles or inflammation. For the three discordant layers considered BCC-positive by frozen section histology, it is uncertain whether the disagreements were caused by a failure to detect BCC by the Fast Raman device or byhistology miss-diagnoses caused by tissue processing. The Fast Raman device has the potential to provide important benefits to Mohs surgery byreducing the duration and costs of tissue processing and by decreasing diagnosis subjectivity and inter-user variability. The successful integration in the clinical pathway is an important step towards a larger diagnostic test accuracy study.

U2 - 10.1364/BOE.417896

DO - 10.1364/BOE.417896

M3 - Article

VL - 12

SP - 2015

EP - 2026

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 4

ER -