With the advent of the knowledge economy and the growing importance of knowledge societies, organizations are constantly seeking new ways of leveraging knowledge assets to support Decision Making (DM) processes. This chapter presents an initial insight to the little-researched phenomenon of how Knowledge Management Systems (KMSs) can support DM processes in organizations. A synthesis of ideas from a literature review suggests a new conceptual framework with several critical factors that organizations should take into account to assess the usage of KMSs tools in supporting DM processes in organizations. The proposed framework, “USUQ,” will benefit managers in both public and private sectors in knowing how the Usage, Satisfaction, Usefulness, and the Quality of using KMSs can support DM processes.