BCAP is a centriolar satellite protein and inhibitor of ciliogenesis. / De Saram, Paulu; Iqbal, Anila; Murdoch, Jennifer; Wilkinson, Christopher.

In: Journal of Cell Science, Vol. 130, No. 19, 2017, p. 3360-3373.

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BCAP is a centriolar satellite protein and inhibitor of ciliogenesis. / De Saram, Paulu; Iqbal, Anila; Murdoch, Jennifer; Wilkinson, Christopher.

In: Journal of Cell Science, Vol. 130, No. 19, 2017, p. 3360-3373.

Research output: Contribution to journalArticlepeer-review

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@article{b42fd43be84e467a83e9710fe38036c0,
title = "BCAP is a centriolar satellite protein and inhibitor of ciliogenesis",
abstract = "The centrosome and cilium are organelles with important roles in microtubule organisation, cell division, cell signalling, embryogenesis, and tissue homeostasis. The two organelles are mutually exclusive. The centriole/basal body is found at the core of the centrosome (centriole) or at the base of the cilium (basal body) and changing which organelle is present in a cell requires modification to the centriole/basal body both in terms of composition and sub-cellular localisation. While many protein components required for centrosome and cilium biogenesis have been described, there are far fewer known inhibitors of ciliogenesis. Here we show that a protein called BCAP and labelled in the sequence databases as ODF2-like (ODF2L) is a ciliation inhibitor. We show that it is a centriolar satellite protein. Furthermore, our data suggest BCAP exists as two isoforms with subtly different roles in inhibition of ciliogenesis. Both are required to prevent ciliogenesis and one additionally controls cilium length after ciliogenesis has completed.",
author = "{De Saram}, Paulu and Anila Iqbal and Jennifer Murdoch and Christopher Wilkinson",
year = "2017",
doi = "10.1242/jcs.196642",
language = "English",
volume = "130",
pages = "3360--3373",
journal = "Journal of Cell Science",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "19",

}

RIS

TY - JOUR

T1 - BCAP is a centriolar satellite protein and inhibitor of ciliogenesis

AU - De Saram, Paulu

AU - Iqbal, Anila

AU - Murdoch, Jennifer

AU - Wilkinson, Christopher

PY - 2017

Y1 - 2017

N2 - The centrosome and cilium are organelles with important roles in microtubule organisation, cell division, cell signalling, embryogenesis, and tissue homeostasis. The two organelles are mutually exclusive. The centriole/basal body is found at the core of the centrosome (centriole) or at the base of the cilium (basal body) and changing which organelle is present in a cell requires modification to the centriole/basal body both in terms of composition and sub-cellular localisation. While many protein components required for centrosome and cilium biogenesis have been described, there are far fewer known inhibitors of ciliogenesis. Here we show that a protein called BCAP and labelled in the sequence databases as ODF2-like (ODF2L) is a ciliation inhibitor. We show that it is a centriolar satellite protein. Furthermore, our data suggest BCAP exists as two isoforms with subtly different roles in inhibition of ciliogenesis. Both are required to prevent ciliogenesis and one additionally controls cilium length after ciliogenesis has completed.

AB - The centrosome and cilium are organelles with important roles in microtubule organisation, cell division, cell signalling, embryogenesis, and tissue homeostasis. The two organelles are mutually exclusive. The centriole/basal body is found at the core of the centrosome (centriole) or at the base of the cilium (basal body) and changing which organelle is present in a cell requires modification to the centriole/basal body both in terms of composition and sub-cellular localisation. While many protein components required for centrosome and cilium biogenesis have been described, there are far fewer known inhibitors of ciliogenesis. Here we show that a protein called BCAP and labelled in the sequence databases as ODF2-like (ODF2L) is a ciliation inhibitor. We show that it is a centriolar satellite protein. Furthermore, our data suggest BCAP exists as two isoforms with subtly different roles in inhibition of ciliogenesis. Both are required to prevent ciliogenesis and one additionally controls cilium length after ciliogenesis has completed.

U2 - 10.1242/jcs.196642

DO - 10.1242/jcs.196642

M3 - Article

VL - 130

SP - 3360

EP - 3373

JO - Journal of Cell Science

JF - Journal of Cell Science

SN - 0021-9533

IS - 19

ER -