APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults. / Shine, J P; Hodgetts, C J; Postans, M; Lawrence, A D; Graham, K S.

In: Scientific Reports, Vol. 5, 16322, 10.11.2015, p. 1-12.

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APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults. / Shine, J P; Hodgetts, C J; Postans, M; Lawrence, A D; Graham, K S.

In: Scientific Reports, Vol. 5, 16322, 10.11.2015, p. 1-12.

Research output: Contribution to journalArticlepeer-review

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Shine, J P ; Hodgetts, C J ; Postans, M ; Lawrence, A D ; Graham, K S. / APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults. In: Scientific Reports. 2015 ; Vol. 5. pp. 1-12.

BibTeX

@article{38bca9649a98499996b23a272d558f53,
title = "APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults",
abstract = "Apolipoprotein E (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD), yet the mechanisms by which APOE-ε4 influences early-life brain function, and hence, in turn, risk for later-life AD, are poorly understood. Here, we report a novel, and selective, pattern of functional brain activity alteration in healthy young adult human APOE-ε4 carriers. Our findings suggest that APOE-ε4 may influence vulnerability to poorer later life cognitive health via its effect on posteromedial cortex (PMC), a hub region within a brain network involved in spatial processing, and necessary for episodic memory. In two neuroimaging tasks, APOE-ε4 carriers showed an inability to effectively modulate PMC during scene, but not face and object, working memory and perception. This striking pattern overlaps both functionally and topographically, with the earliest cognitive deficits seen in clinical AD, as well as reported alterations in the default network in amyloid-positive individuals at increased risk of AD. ",
keywords = "Alzheimer Disease/genetics, Apolipoprotein E4/genetics, Brain/diagnostic imaging, Cerebral Cortex/physiology, Female, Genotype, Humans, Magnetic Resonance Imaging, Male, Memory, Short-Term, Photic Stimulation, Polymorphism, Single Nucleotide, Radiography, Risk Factors, Visual Perception, Young Adult",
author = "Shine, {J P} and Hodgetts, {C J} and M Postans and Lawrence, {A D} and Graham, {K S}",
year = "2015",
month = nov,
day = "10",
doi = "10.1038/srep16322",
language = "English",
volume = "5",
pages = "1--12",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults

AU - Shine, J P

AU - Hodgetts, C J

AU - Postans, M

AU - Lawrence, A D

AU - Graham, K S

PY - 2015/11/10

Y1 - 2015/11/10

N2 - Apolipoprotein E (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD), yet the mechanisms by which APOE-ε4 influences early-life brain function, and hence, in turn, risk for later-life AD, are poorly understood. Here, we report a novel, and selective, pattern of functional brain activity alteration in healthy young adult human APOE-ε4 carriers. Our findings suggest that APOE-ε4 may influence vulnerability to poorer later life cognitive health via its effect on posteromedial cortex (PMC), a hub region within a brain network involved in spatial processing, and necessary for episodic memory. In two neuroimaging tasks, APOE-ε4 carriers showed an inability to effectively modulate PMC during scene, but not face and object, working memory and perception. This striking pattern overlaps both functionally and topographically, with the earliest cognitive deficits seen in clinical AD, as well as reported alterations in the default network in amyloid-positive individuals at increased risk of AD.

AB - Apolipoprotein E (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD), yet the mechanisms by which APOE-ε4 influences early-life brain function, and hence, in turn, risk for later-life AD, are poorly understood. Here, we report a novel, and selective, pattern of functional brain activity alteration in healthy young adult human APOE-ε4 carriers. Our findings suggest that APOE-ε4 may influence vulnerability to poorer later life cognitive health via its effect on posteromedial cortex (PMC), a hub region within a brain network involved in spatial processing, and necessary for episodic memory. In two neuroimaging tasks, APOE-ε4 carriers showed an inability to effectively modulate PMC during scene, but not face and object, working memory and perception. This striking pattern overlaps both functionally and topographically, with the earliest cognitive deficits seen in clinical AD, as well as reported alterations in the default network in amyloid-positive individuals at increased risk of AD.

KW - Alzheimer Disease/genetics

KW - Apolipoprotein E4/genetics

KW - Brain/diagnostic imaging

KW - Cerebral Cortex/physiology

KW - Female

KW - Genotype

KW - Humans

KW - Magnetic Resonance Imaging

KW - Male

KW - Memory, Short-Term

KW - Photic Stimulation

KW - Polymorphism, Single Nucleotide

KW - Radiography

KW - Risk Factors

KW - Visual Perception

KW - Young Adult

U2 - 10.1038/srep16322

DO - 10.1038/srep16322

M3 - Article

C2 - 26552581

VL - 5

SP - 1

EP - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 16322

ER -