APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults. / Shine, J P; Hodgetts, C J; Postans, M; Lawrence, A D; Graham, K S.
In: Scientific Reports, Vol. 5, 16322, 10.11.2015, p. 1-12.Research output: Contribution to journal › Article › peer-review
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APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults. / Shine, J P; Hodgetts, C J; Postans, M; Lawrence, A D; Graham, K S.
In: Scientific Reports, Vol. 5, 16322, 10.11.2015, p. 1-12.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - APOE-ε4 selectively modulates posteromedial cortex activity during scene perception and short-term memory in young healthy adults
AU - Shine, J P
AU - Hodgetts, C J
AU - Postans, M
AU - Lawrence, A D
AU - Graham, K S
PY - 2015/11/10
Y1 - 2015/11/10
N2 - Apolipoprotein E (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD), yet the mechanisms by which APOE-ε4 influences early-life brain function, and hence, in turn, risk for later-life AD, are poorly understood. Here, we report a novel, and selective, pattern of functional brain activity alteration in healthy young adult human APOE-ε4 carriers. Our findings suggest that APOE-ε4 may influence vulnerability to poorer later life cognitive health via its effect on posteromedial cortex (PMC), a hub region within a brain network involved in spatial processing, and necessary for episodic memory. In two neuroimaging tasks, APOE-ε4 carriers showed an inability to effectively modulate PMC during scene, but not face and object, working memory and perception. This striking pattern overlaps both functionally and topographically, with the earliest cognitive deficits seen in clinical AD, as well as reported alterations in the default network in amyloid-positive individuals at increased risk of AD.
AB - Apolipoprotein E (APOE) ε4 is a major genetic risk factor for Alzheimer's disease (AD), yet the mechanisms by which APOE-ε4 influences early-life brain function, and hence, in turn, risk for later-life AD, are poorly understood. Here, we report a novel, and selective, pattern of functional brain activity alteration in healthy young adult human APOE-ε4 carriers. Our findings suggest that APOE-ε4 may influence vulnerability to poorer later life cognitive health via its effect on posteromedial cortex (PMC), a hub region within a brain network involved in spatial processing, and necessary for episodic memory. In two neuroimaging tasks, APOE-ε4 carriers showed an inability to effectively modulate PMC during scene, but not face and object, working memory and perception. This striking pattern overlaps both functionally and topographically, with the earliest cognitive deficits seen in clinical AD, as well as reported alterations in the default network in amyloid-positive individuals at increased risk of AD.
KW - Alzheimer Disease/genetics
KW - Apolipoprotein E4/genetics
KW - Brain/diagnostic imaging
KW - Cerebral Cortex/physiology
KW - Female
KW - Genotype
KW - Humans
KW - Magnetic Resonance Imaging
KW - Male
KW - Memory, Short-Term
KW - Photic Stimulation
KW - Polymorphism, Single Nucleotide
KW - Radiography
KW - Risk Factors
KW - Visual Perception
KW - Young Adult
U2 - 10.1038/srep16322
DO - 10.1038/srep16322
M3 - Article
C2 - 26552581
VL - 5
SP - 1
EP - 12
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
M1 - 16322
ER -