A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach

Matthew Traylor; Kari-Matti Mäkelä; Laura L Kilarski; Elizabeth G Holliday; William J Devan; Mike A Nalls; Kerri L Wiggins; Wei Zhao; Yu-Ching Cheng; Sefanja Achterberg; Rainer Malik; Cathie Sudlow; Steve Bevan; Emma Raitoharju; Niku Oksala; Vincent Thijs; Robin Lemmens; Arne Lindgren; Agnieszka Slowik; Jane M Maguire; Matthew Walters; Ale Algra; Pankaj Sharma; John R Attia; Giorgio B Boncoraglio; Peter M Rothwell; Paul I W de Bakker; Joshua C Bis; Danish Saleheen; Steven J Kittner; Braxton D Mitchell; Jonathan Rosand; James F Meschia; Christopher Levi; Martin Dichgans; Terho Lehtimäki; Cathryn M Lewis; Hugh S Markus; METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2)

doi:10.1371/journal.pgen.1004469

A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach

Matthew Traylor, Kari-Matti Mäkelä, Laura L Kilarski, Elizabeth G Holliday, William J Devan, Mike A Nalls, Kerri L Wiggins, Wei Zhao, Yu-Ching Cheng, Sefanja Achterberg, Rainer Malik, Cathie Sudlow, Steve Bevan, Emma Raitoharju, Niku Oksala, Vincent Thijs, Robin Lemmens, Arne Lindgren, Agnieszka Slowik, Jane M MaguireMatthew Walters, Ale Algra, Pankaj Sharma, John R Attia, Giorgio B Boncoraglio, Peter M Rothwell, Paul I W de Bakker, Joshua C Bis, Danish Saleheen, Steven J Kittner, Braxton D Mitchell, Jonathan Rosand, James F Meschia, Christopher Levi, Martin Dichgans, Terho Lehtimäki, Cathryn M Lewis, Hugh S Markus, METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2)

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	e1004469
Journal	PLoS genetics
Volume	10
Issue number	7
DOIs	https://doi.org/10.1371/journal.pgen.1004469
Publication status	Published - Jul 2014

Keywords

Adult
Age of Onset
Aged
Arteries
Coronary Artery Disease
Female
Genome-Wide Association Study
Glycosaminoglycans
Humans
Male
Matrix Metalloproteinase 12
Middle Aged
Myocardial Infarction
Polymorphism, Single Nucleotide

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10.1371/journal.pgen.1004469

Cite this

Traylor, M., Mäkelä, K.-M., Kilarski, L. L., Holliday, E. G., Devan, W. J., Nalls, M. A., Wiggins, K. L., Zhao, W., Cheng, Y.-C., Achterberg, S., Malik, R., Sudlow, C., Bevan, S., Raitoharju, E., Oksala, N., Thijs, V., Lemmens, R., Lindgren, A., Slowik, A., ... METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2) (2014). A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach. PLoS genetics, 10(7), e1004469. https://doi.org/10.1371/journal.pgen.1004469

@article{88e7f7055091413ab271feb6e4dcf6bc,

title = "A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach",

keywords = "Adult, Age of Onset, Aged, Arteries, Coronary Artery Disease, Female, Genome-Wide Association Study, Glycosaminoglycans, Humans, Male, Matrix Metalloproteinase 12, Middle Aged, Myocardial Infarction, Polymorphism, Single Nucleotide",

author = "Matthew Traylor and Kari-Matti M{\"a}kel{\"a} and Kilarski, {Laura L} and Holliday, {Elizabeth G} and Devan, {William J} and Nalls, {Mike A} and Wiggins, {Kerri L} and Wei Zhao and Yu-Ching Cheng and Sefanja Achterberg and Rainer Malik and Cathie Sudlow and Steve Bevan and Emma Raitoharju and Niku Oksala and Vincent Thijs and Robin Lemmens and Arne Lindgren and Agnieszka Slowik and Maguire, {Jane M} and Matthew Walters and Ale Algra and Pankaj Sharma and Attia, {John R} and Boncoraglio, {Giorgio B} and Rothwell, {Peter M} and {de Bakker}, {Paul I W} and Bis, {Joshua C} and Danish Saleheen and Kittner, {Steven J} and Mitchell, {Braxton D} and Jonathan Rosand and Meschia, {James F} and Christopher Levi and Martin Dichgans and Terho Lehtim{\"a}ki and Lewis, {Cathryn M} and Markus, {Hugh S} and {METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2)}",

year = "2014",

month = jul,

doi = "10.1371/journal.pgen.1004469",

language = "English",

volume = "10",

pages = "e1004469",

journal = "PLoS genetics",

issn = "1553-7404",

publisher = "Public Library of Science",

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Traylor, M, Mäkelä, K-M, Kilarski, LL, Holliday, EG, Devan, WJ, Nalls, MA, Wiggins, KL, Zhao, W, Cheng, Y-C, Achterberg, S, Malik, R, Sudlow, C, Bevan, S, Raitoharju, E, Oksala, N, Thijs, V, Lemmens, R, Lindgren, A, Slowik, A, Maguire, JM, Walters, M, Algra, A, Sharma, P, Attia, JR, Boncoraglio, GB, Rothwell, PM, de Bakker, PIW, Bis, JC, Saleheen, D, Kittner, SJ, Mitchell, BD, Rosand, J, Meschia, JF, Levi, C, Dichgans, M, Lehtimäki, T, Lewis, CM, Markus, HS & METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2) 2014, 'A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach', PLoS genetics, vol. 10, no. 7, pp. e1004469. https://doi.org/10.1371/journal.pgen.1004469

TY - JOUR

T1 - A novel MMP12 locus is associated with large artery atherosclerotic stroke using a genome-wide age-at-onset informed approach

AU - Traylor, Matthew

AU - Mäkelä, Kari-Matti

AU - Kilarski, Laura L

AU - Holliday, Elizabeth G

AU - Devan, William J

AU - Nalls, Mike A

AU - Wiggins, Kerri L

AU - Zhao, Wei

AU - Cheng, Yu-Ching

AU - Achterberg, Sefanja

AU - Malik, Rainer

AU - Sudlow, Cathie

AU - Bevan, Steve

AU - Raitoharju, Emma

AU - Oksala, Niku

AU - Thijs, Vincent

AU - Lemmens, Robin

AU - Lindgren, Arne

AU - Slowik, Agnieszka

AU - Maguire, Jane M

AU - Walters, Matthew

AU - Algra, Ale

AU - Sharma, Pankaj

AU - Attia, John R

AU - Boncoraglio, Giorgio B

AU - Rothwell, Peter M

AU - de Bakker, Paul I W

AU - Bis, Joshua C

AU - Saleheen, Danish

AU - Kittner, Steven J

AU - Mitchell, Braxton D

AU - Rosand, Jonathan

AU - Meschia, James F

AU - Levi, Christopher

AU - Dichgans, Martin

AU - Lehtimäki, Terho

AU - Lewis, Cathryn M

AU - Markus, Hugh S

AU - METASTROKE, International Stroke Genetics Consortium, Wellcome Trust Case Consortium 2 (WTCCC2)

PY - 2014/7

Y1 - 2014/7

KW - Adult

KW - Age of Onset

KW - Aged

KW - Arteries

KW - Coronary Artery Disease

KW - Female

KW - Genome-Wide Association Study

KW - Glycosaminoglycans

KW - Humans

KW - Male

KW - Matrix Metalloproteinase 12

KW - Middle Aged

KW - Myocardial Infarction

KW - Polymorphism, Single Nucleotide

U2 - 10.1371/journal.pgen.1004469

DO - 10.1371/journal.pgen.1004469

M3 - Article

C2 - 25078452

SN - 1553-7404

VL - 10

SP - e1004469

JO - PLoS genetics

JF - PLoS genetics

IS - 7

ER -