Dr Takis Athanasopoulos

  1. 2019
  2. E-pub ahead of print

    Vaccination of macaques with DNA followed by adenoviral vectors encoding SIV gag alone delays infection by repeated mucosal challenge with SIV

    Almond, N., Berry, N., Stebbings, R., Preston, M., Ham, C., Page, M., Ferguson, D., Rose, N., Li, B., Mee, E. T., Hassall, M., Stahl-Hennig, C., Athanasopoulos, T., Papagatsias, T., Herath, S., Benlahrech, A., Dickson, G., Meiser, A. & Patterson, S., 14 Aug 2019, In : Journal of virology. p. 1-38 38 p.

    Research output: Contribution to journalArticle

  3. 2017
  4. Published

    Nonintegrating Gene Therapy Vectors

    Athanasopoulos, T., Munye, M. M. & Yáñez-Muñoz, R. J., Oct 2017, In : Hematology/Oncology Clinics of North America. 31, 5, p. 753-770 18 p.

    Research output: Contribution to journalArticle

  5. Published

    Long-term microdystrophin gene therapy is effective in a canine model of Duchenne muscular dystrophy

    Le Guiner, C., Servais, L., Montus, M., Larcher, T., Fraysse, B., Moullec, S., Allais, M., François, V., Dutilleul, M., Malerba, A., Koo, T., Thibaut, J-L., Matot, B., Devaux, M., Le Duff, J., Deschamps, J-Y., Barthelemy, I., Blot, S., Testault, I., Wahbi, K. & 15 others, Ederhy, S., Martin, S., Veron, P., Georger, C., Athanasopoulos, T., Masurier, C., Mingozzi, F., Carlier, P., Gjata, B., Hogrel, J-Y., Adjali, O., Mavilio, F., Voit, T., Moullier, P. & Dickson, G., 25 Jul 2017, In : Nature Communications. 8, p. 1-15 15 p., 16105.

    Research output: Contribution to journalArticle

  6. 2016
  7. Published

    piggyBac transposons expressing full-length human dystrophin enable genetic correction of dystrophic mesoangioblasts

    Loperfido, M., Jarmin, S., Dastidar, S., Di Matteo, M., Perini, I., Moore, M., Nair, N., Samara-Kuko, E., Athanasopoulos, T., Tedesco, F. S., Dickson, G., Sampaolesi, M., VandenDriessche, T. & Chuah, M. K., 29 Jan 2016, In : Nucleic Acids Research. 44, 2, p. 744-760 17 p.

    Research output: Contribution to journalArticle

  8. 2015
  9. Published

    Abnormal splicing switch of DMD's penultimate exon compromises muscle fibre maintenance in myotonic dystrophy

    Rau, F., Lainé, J., Ramanoudjame, L., Ferry, A., Arandel, L., Delalande, O., Jollet, A., Dingli, F., Lee, K-Y., Peccate, C., Lorain, S., Kabashi, E., Athanasopoulos, T., Koo, T., Loew, D., Swanson, M. S., Le Rumeur, E., Dickson, G., Allamand, V., Marie, J. & 1 others, Furling, D., 28 May 2015, In : Nature Communications. 6, p. 1-10 10 p., 7205.

    Research output: Contribution to journalArticle

  10. Published

    Adeno-Associated Virus (AAV) Mediated Dystrophin Gene Transfer Studies and Exon Skipping Strategies for Duchenne Muscular Dystrophy (DMD)

    Kawecka, K., Theodoulides, M., Hasoglu, Y., Jarmin, S., Kymalainen, H., Le-Heron, A., Popplewell, L., Malerba, A., Dickson, G. & Athanasopoulos, T., 2015, In : Current Gene Therapy. 15, 4, p. 395-415 21 p.

    Research output: Contribution to journalArticle

  11. 2014
  12. Published

    Genome-Wide Computational Analysis Reveals Cardiomyocyte-Specific Transcriptional CIS-Regulatory Motifs that Enable Efficient Cardiac Gene Therapy

    Rincon, M. Y., Sarcar, S., Danso-Abeam, D., Keyaerts, M., Matrai, J., Samara-Kuko, E., Acosta-Sanchez, A., Athanasopoulos, T., Dickson, G., Lahoutte, T., De Bleser, P., VandenDriessche, T. & Chuah, M. K., 8 Sep 2014, In : Molecular Therapy.

    Research output: Contribution to journalArticle

  13. Published
  14. Published

    Fusion of Ubiquitin to HIV Gag Impairs Human Monocyte-Derived Dendritic Cell Maturation and Reduces Ability to Induce Gag T Cell Responses

    Herath, S., Benlahrech, A., Papagatsias, T., Athanasopoulos, T., Bouzeboudjen, Z., Hervouet, C., Klavinskis, L., Meiser, A., Kelleher, P., Dickson, G. & Patterson, S., 2014, In : PLoS ONE. 9, 2, p. e88327

    Research output: Contribution to journalArticle

  15. 2013
  16. Published

    Langerin negative dendritic cells promote potent CD8+ T-cell priming by skin delivery of live adenovirus vaccine microneedle arrays

    Bachy, V., Hervouet, C., Becker, P. D., Chorro, L., Carlin, L. M., Herath, S., Papagatsias, T., Barbaroux, J-B., Oh, S-J., Benlahrech, A., Athanasopoulos, T., Dickson, G., Patterson, S., Kwon, S-Y., Geissmann, F. & Klavinskis, L. S., 2013, In : Proceedings of the National Academy of Sciences of the United States of America.

    Research output: Contribution to journalArticle

  17. 2012
  18. Published

    Fragmentation of SIV-gag Vaccine Induces Broader T Cell Responses

    Benlahrech, A., Meiser, A., Herath, S., Papagatsias, T., Athanasopoulos, T., Li, F., Self, S., Bachy, V., Hervouet, C., Logan, K., Klavinskis, L., Dickson, G. & Patterson, S., 31 Oct 2012, In : PLoS ONE. 7, 10, 13 p., ARTN e48038.

    Research output: Contribution to journalArticle

  19. Published

    Highly potent delivery method of gp160 envelope vaccine combining lentivirus-like particles and DNA electrotransfer

    Vandermeulen, G., Athanasopoulos, T., Trundley, A., Foster, K., Préat, V., Yáñez-Muñoz, R. J. & Dickson, G., 10 May 2012, In : Journal of Controlled Release. 159, 3, p. 376–383

    Research output: Contribution to journalArticle

  20. 2011
  21. Published

    β-catenin as a potential key target for tumor suppression

    Fu, Y., Zheng, S., An, N., Athanasopoulos, T., Popplewell, L., Liang, A., Li, K., Hu, C. & Zhu, Y., 1 Oct 2011, In : International journal of cancer. Journal international du cancer. 129, 7, p. 1541-51 11 p.

    Research output: Contribution to journalReview article

  22. Published

    Adeno-associated virus serotypes 7 and 8 outperform serotype 9 in expressing atheroprotective human apoE3 from mouse skeletal muscle

    Evans, V. C., Graham, I. R., Athanasopoulos, T., Galley, D. J., Jackson, C. L., Simons, J. P., Dickson, G. & Owen, J. S., 2011, In : Metabolism: clinical and experimental. 60, 4, p. 491-8

    Research output: Contribution to journalArticle

  23. Published

    Codon optimization of the microdystrophin gene for duchene muscular dystrophy gene therapy

    Athanasopoulos, T., Foster, H., Foster, K. & Dickson, G., 2011, In : Methods in Molecular Biology. 709, p. 21-37 17 p.

    Research output: Contribution to journalArticle

  24. Published
  25. Published

    Transcription Factor Rational Design Improves Directed Differentiation of Human Mesenchymal Stem Cells Into Skeletal Myocytes

    Gonçalves, M. A., Janssen, J. M., Nguyen, Q. G., Athanasopoulos, T., Hauschka, S. D., Dickson, G. & de Vries, A. A., 2011, In : Molecular Therapy. 19, 7, p. 1331-41

    Research output: Contribution to journalArticle

  26. 2010
  27. Published

    Canine microdystrophin results in remarkable expression and improvement in muscle pathology in a canine model of Duchenne Muscular Dystrophy following AAV gene transfer

    Koo, T., Shin, J. H., Athanasopoulos, T., Takashi, O., Foster, H., Shin'ichi, T. & Dickson, G., Oct 2010, In : Human Gene Therapy. 21, 10, p. 1469-1470 2 p.

    Research output: Contribution to journalArticle

  28. Published

    Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization

    Ghahramani Seno, M. M., Trollet, C., Athanasopoulos, T., Graham, I. R., Hu, P. & Dickson, G., 2010, In : BMC Genomics. 11, p. 345

    Research output: Contribution to journalArticle

  29. 2009
  30. Published

    Development of thermo-stable Ad-based vaccines expressing ubiquitin fusions of full or fragmented HIV/SIV genetic components

    Athanasopoulos, T., Papagatsias, T., Meiser, A., Harris, J., Bachy, V., Benlahrech, A., Herath, S., Roesen, N., Oh, S., Li, F., Self, S., Kwon, S-Y., Fischer, K., Seymour, L., Daniels, R., Almond, N., Klavinskis, L., Logan, K., Patterson, S. & Dickson, G., Nov 2009, In : Human Gene Therapy. 20, 11, p. 1392-1393 2 p.

    Research output: Contribution to journalArticle

  31. Published

    Gene therapy for muscular dystrophy: current progress and future prospects

    Trollet, C., Athanasopoulos, T., Popplewell, L., Malerba, A. & Dickson, G., Jul 2009, In : Expert Opinion on Biological Therapy. 9, 7, p. 849-866 18 p.

    Research output: Contribution to journalLiterature review

  32. Published

    Adenovirus vector vaccination induces expansion of memory CD4 T cells with a mucosal homing phenotype that are readily susceptible to HIV-1

    Benlahrech, A., Harris, J., Meiser, A., Papagatsias, T., Hornig, J., Hayes, P., Lieber, A., Athanasopoulos, T., Bachy, V., Csomor, E., Daniels, R., Fisher, K., Gotch, F., Seymour, L., Logan, K., Barbagallo, R., Klavinskis, L., Dickson, G. & Patterson, S., 2009, In : Proceedings of the National Academy of Sciences of the United States of America. 106, 47, p. 19940-5 6 p.

    Research output: Contribution to journalArticle

  33. Published

    Preliminary evaluation of a self-complementary AAV2/8 vector for hepatic gene transfer of human apoE3 to inhibit atherosclerotic lesion development in apoE-deficient mice

    Osman, E., Evans, V., Graham, I. R., Athanasopoulos, T., McIntosh, J., Nathwani, A. C., Simons, J. P., Dickson, G. & Owen, J. S., 2009, In : Atherosclerosis. 204, 1, p. 121-6 6 p.

    Research output: Contribution to journalArticle

  34. 2008
  35. Published

    Activity of different vaccine-associated promoter elements in human dendritic cells

    Papagatsias, T., Rozis, G., Athanasopoulos, T., Gotch, F., Dickson, G. & Patterson, S., 2008, In : Immunology Letters. 115, 2, p. 117-25 9 p.

    Research output: Contribution to journalArticle

  36. Published

    Codon and mRNA sequence optimization of microdystrophin transgenes improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer

    Foster, H., Sharp, P. S., Athanasopoulos, T., Trollet, C., Graham, I. R., Foster, K., Wells, D. J. & Dickson, G., 2008, In : Molecular Therapy. 16, 11, p. 1825-32 8 p.

    Research output: Contribution to journalArticle

  37. Published

    Human apolipoprotein E expression from mouse skeletal muscle by electrotransfer of nonviral DNA (plasmid) and pseudotyped recombinant adeno-associated virus (AAV2/7)

    Evans, V., Foster, H., Graham, I. R., Foster, K., Athanasopoulos, T., Simons, J. P., Dickson, G. & Owen, J. S., 2008, In : Human Gene Therapy. 19, 6, p. 569-78 10 p.

    Research output: Contribution to journalArticle

  38. Published

    RNAi-mediated knockdown of dystrophin expression in adult mice does not lead to overt muscular dystrophy pathology

    Ghahramani Seno, M. M., Graham, I. R., Athanasopoulos, T., Trollet, C., Pohlschmidt, M., Crompton, M. R. & Dickson, G., 2008, In : Human Molecular Genetics. 17, 17, p. 2622-32 11 p.

    Research output: Contribution to journalArticle

  39. 2004
  40. Published

    Recombinant adeno-associated viral (rAAV) vectors as therapeutic tools for Duchenne muscular dystrophy (DMD)

    Athanasopoulos, T., Graham, I. R., Foster, H. & Dickson, G., Oct 2004, In : Human Gene Therapy. 11 Suppl 1, p. S109-S121 13 p.

    Research output: Contribution to journalArticle

  41. 2002
  42. Published

    Inhibition of atherosclerosis in apolipoprotein-E-deficient mice following muscle transduction with adeno-associated virus vectors encoding human apolipoprotein-E

    Harris, J. D., Schepelmann, S., Athanasopoulos, T., Graham, I. R., Stannard, A. K., Mohri, Z., Hill, V., Hassall, D. G., Owen, J. S. & Dickson, G., 31 Jan 2002, In : Human Gene Therapy. 9, 1, p. 21-29 9 p.

    Research output: Contribution to journalArticle

  43. 2001
  44. Published

    Cell-derived apolipoprotein E (ApoE) particles inhibit vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells

    Stannard, A. K., Riddell, D. R., Sacre, S. M., Tagalakis, A. D., Langer, C., von Eckardstein, A., Cullen, P., Athanasopoulos, T., Dickson, G. & Owen, J. S., 2001, In : Journal of Biological Chemistry. 276, 49, p. 46011-6 6 p.

    Research output: Contribution to journalArticle

  45. Published

    Post-mitotic, differentiated myotubes efficiently produce retroviral vector from hybrid adeno-retrovirus templates

    Roberts, M. L., Athanasopoulos, T., Pohlschmidt, M., Duisit, G., Cosset, F. L. & Dickson, G., 2001, In : Human Gene Therapy. 8, 20, p. 1580-6 7 p.

    Research output: Contribution to journalArticle

  46. 2000
  47. Published

    Intramuscular injection of a plasmid vector expressing human apolipoprotein E limits progression of xanthoma and aortic atheroma in apoE-deficient mice

    Athanasopoulos, T., Owen, J. S., Hassall, D., Dunckley, M. G., Drew, J., Goodman, J., Tagalakis, A. D., Riddell, D. R. & Dickson, G., 12 Oct 2000, In : Human Molecular Genetics. 9, 17, p. 2545-2551 7 p.

    Research output: Contribution to journalArticle

  48. Published

    Gene therapy vectors based on adeno-associated virus: characteristics and applications to acquired and inherited diseases (review)

    Athanasopoulos, T., Fabb, S. & Dickson, G., 2000, In : INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 6, 4, p. 363-375 13 p.

    Research output: Contribution to journalLiterature review

  49. 1999
  50. Published

    Gene therapy for atherosclerosis: A comparative study of adeno-associated virus (AAV) and conventional plasmid vectors encoding human apolipopoprotein E (apoE) cDNAs

    Athanasopoulos, P. T., Dunckley, M. G., Hassall, D. G., Fabb, S., Tagalakis, A. D., Shepelmann, S., Owen, J. & Dickson, J. G., May 1999, In : Atherosclerosis. 144, p. 93-94 2 p.

    Research output: Contribution to journalArticle

  51. Published

    Locally secreted apolipoprotein (apo)E inhibits vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells

    Stannard, A. K., Riddell, D. R., Tagalakis, A. D., Athanasopoulos, T., Dickson, J. G. & Owen, J. S., May 1999, In : Atherosclerosis. 144, p. 86-86 1 p.

    Research output: Contribution to journalArticle

  52. Published

    Muscle-based expression of antiatherogenic high density lipoprotein components using recombinant adeno-associated virus based vectors

    Athanasopoulos, P. T., Schepelmann, S., Fan, L., Hassall, D. G., Fabb, S., Owen, J. & Dickson, J. G., May 1999, In : Atherosclerosis. 144, p. 168-168 1 p.

    Research output: Contribution to journalArticle

  53. 1998
  54. Published

    Gene therapy for hyperlipidaemia: Insights from heterologous muscle-based expression of serum apolipoprotein E (apoE) in apoE(-)/(-) mice

    Athanasopoulos, T., Drew, J., Dunckley, M. G., Goodman, J., Hassall, D. G., Riddell, D. R., Owen, J. S. & Dickson, G., Nov 1998, In : Atherosclerosis. 141, 1, p. 184-184 1 p.

    Research output: Contribution to journalArticle