Dr Linda Popplewell

  1. 2020
  2. Published

    G-quadruplex ligands mediate downregulation of DUX4 expression

    Ciszewski, L., Lu-Nguyen, N., Dickson, G. & Popplewell, L., 17 Mar 2020, In : Nucleic Acids Research. p. 1-16 16 p., gkaa146.

    Research output: Contribution to journalArticle

  3. Published

    Inhibition of Myostatin Reduces Collagen Deposition in a Mouse Model of Oculopharyngeal Muscular Dystrophy (OPMD) With Established Disease

    Harish, P., Forrest, L., Herath, S., Dickson, G., Malerba, A. & Popplewell, L., 5 Mar 2020, In : Frontiers in Physiology. 11, p. 1-8 8 p., 184.

    Research output: Contribution to journalArticle

  4. 2019
  5. E-pub ahead of print

    Functional muscle recovery following dystrophin and myostatin exon splice modulation in aged mdx mice

    Lu-Nguyen, N., Ferry, A., Schnell, F. J., Hanson, G. J., Popplewell, L., Dickson, G. & Malerba, A., 10 Jun 2019, In : Human Molecular Genetics. ddz125.

    Research output: Contribution to journalArticle

  6. E-pub ahead of print

    Inhibition of myostatin improves muscle atrophy in oculopharyngeal muscular dystrophy (OPMD)

    Harish, P., Malerba, A., Lu-Nguyen, N., Forrest, L., Cappellari, O., Roth, F., Trollet, C., Popplewell, L. & Dickson, J., 7 May 2019, In : Journal of Cachexia, Sarcopenia and Muscle. p. 1-11 11 p.

    Research output: Contribution to journalArticle

  7. 2018
  8. Published

    A multicenter comparison of quantification methods for antisense oligonucleotide-induced DMD exon 51 skipping in Duchenne muscular dystrophy cell cultures

    Hiller, M., Falzarano, M. S., Garcia-Jimenez, I., Sardone, V., Verheul, R. C., Popplewell, L., Anthony, K., Ruiz-Del-Yerro, E., Osman, H., Goeman, J. J., Mamchaoui, K., Dickson, G., Ferlini, A., Muntoni, F., Aartsma-Rus, A., Arechavala-Gomeza, V., Datson, N. A. & Spitali, P., 2 Oct 2018, In : PLoS ONE. 13, 10, p. 1-15 15 p., e0204485.

    Research output: Contribution to journalArticle

  9. Published

    Editorial of the Special Issue: Antisense Therapies

    Popplewell, L. J., 27 Sep 2018, In : Biomedicines. 6, 4, p. 1-2 2 p., 95.

    Research output: Contribution to journalArticle

  10. E-pub ahead of print

    Antisense Oligonucleotide Targeting of 3'-UTR of mRNA for Expression Knockdown

    Golshirazi, G., Ciszewski, L., Lu-Nguyen, N. & Popplewell, L., 1 Sep 2018, In : Methods in Molecular Biology. 1828, p. 91-124 34 p.

    Research output: Contribution to journalArticle

  11. Published

    Targeting TGFβ Signaling to Address Fibrosis Using Antisense Oligonucleotides

    March, J. T., Golshirazi, G., Cernisova, V., Carr, H., Leong, Y., Lu-Nguyen, N. & Popplewell, L. J., 25 Jun 2018, In : Biomedicines. 6, 3

    Research output: Contribution to journalReview article

  12. Published

    Functional Rescue of Dystrophin Deficiency in Mice Caused by Frameshift Mutations Using Campylobacter jejuni Cas9

    Koo, T., Lu-Nguyen, N. B., Malerba, A., Kim, E., Kim, D., Cappellari, O., Cho, H-Y., Dickson, G., Popplewell, L. & Kim, J-S., 6 Jun 2018, In : Molecular Therapy. 26, 6, p. 1529-1538 10 p.

    Research output: Contribution to journalArticle

  13. Published

    Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy

    Benedetti, S., Uno, N., Hoshiya, H., Ragazzi, M., Ferrari, G., Kazuki, Y., Moyle, L. A., Tonlorenzi, R., Lombardo, A., Chaouch, S., Mouly, V., Moore, M., Popplewell, L., Kazuki, K., Katoh, M., Naldini, L., Dickson, G., Messina, G., Oshimura, M., Cossu, G. & 1 others, Tedesco, F. S., 1 Feb 2018, In : EMBO Reports. 10, 2, p. 254-275 22 p.

    Research output: Contribution to journalArticle

  14. Submitted

    Neurodegenerative disorders

    Alifragis, P. & Popplewell, L., 2018, (Submitted)

    Research output: Patent

  15. 2017
  16. Published

    Systemic Antisense Therapeutics for Dystrophin and Myostatin Exon Splice Modulation Improve Muscle Pathology of Adult mdx Mice

    Lu-Nguyen, N., Malerba, A., Popplewell, L., Schnell, F., Hanson, G. & Dickson, G., 17 Mar 2017, In : Molecular therapy. Nucleic acids. 6, p. 15-28 14 p.

    Research output: Contribution to journalArticle

  17. 2016
  18. Published

    Nuclear poly(A)-binding protein aggregates misplace a pre-mRNA outside of SC35 speckle causing its abnormal splicing

    Klein, P., Oloko, M., Roth, F., Montel, V., Malerba, A., Jarmin, S., Gidaro, T., Popplewell, L., Perie, S., Lacau St Guily, J., de la Grange, P., Antoniou, M. N., Dickson, G., Butler-Browne, G., Bastide, B., Mouly, V. & Trollet, C., Dec 2016, In : Nucleic Acids Research. 44, 22, p. 10929–10945 17 p.

    Research output: Contribution to journalArticle

  19. Published

    Antisense targeting of 3′ end elements involved in DUX4 mRNA processing is an efficient therapeutic strategy for facioscapulohumeral dystrophy: a new gene-silencing approach

    Marsollier, A-C., Ciszewski, L., Mariot, V., Popplewell, L., Voit, T., Dickson, G. & Dumonceaux, J., 15 Apr 2016, In : Human Molecular Genetics. 25, 8, p. 1468-1478 11 p.

    Research output: Contribution to journalArticle

  20. 2015
  21. Published

    Dp412e: a novel human embryonic dystrophin isoform induced by BMP4 in early differentiated cells

    Massouridès, E., Polentes, J., Mangeot, P-E., Mournetas, V., Nectoux, J., Deburgrave, N., Nusbaum, P., Leturcq, F., Popplewell, L., Dickson, G., Wein, N., Flanigan, K. M., Peschanski, M., Chelly, J. & Pinset, C., 14 Nov 2015, In : Skeletal Muscle. 5, 40, p. 1-18 18 p.

    Research output: Contribution to journalArticle

  22. Published

    Combination antisense treatment for destructive exon skipping of myostatin and open reading frame rescue of dystrophin in neonatal mdx mice

    Lu-Nguyen, N., Jarmin, S. A., Saleh, A. F., Popplewell, L., Gait, M. J. & Dickson, G., Aug 2015, In : Molecular Therapy. 23, 8, p. 1341-1348 8 p.

    Research output: Contribution to journalArticle

  23. Published

    Adeno-Associated Virus (AAV) Mediated Dystrophin Gene Transfer Studies and Exon Skipping Strategies for Duchenne Muscular Dystrophy (DMD)

    Kawecka, K., Theodoulides, M., Hasoglu, Y., Jarmin, S., Kymalainen, H., Le-Heron, A., Popplewell, L., Malerba, A., Dickson, G. & Athanasopoulos, T., 2015, In : Current Gene Therapy. 15, 4, p. 395-415 21 p.

    Research output: Contribution to journalArticle

  24. 2014
  25. Published

    New developments in the use of gene therapy to treat Duchenne muscular dystrophy

    Jarmin, S., Kymalainen, H., Popplewell, L. & Dickson, G., Feb 2014, In : Expert Opinion on Biological Therapy. 14, 2, p. 209-30 22 p.

    Research output: Contribution to journalArticle

  26. Published
  27. 2013
  28. Published

    Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in

    Popplewell, L., Koo, T., Leclerc, X., Duclert, A., Mamchaoui, K., Gouble, A., Mouly, V., Voit, T., Pâques, F., Cédrone, F., Isman, O., Yáñez (or Yáñez-Muñoz), R. J. & Dickson, G., Jul 2013, In : Human Gene Therapy. 24, 7, p. 692-701 10 p.

    Research output: Contribution to journalArticle

  29. Published

    TALEN-directed genome surgery of the DMD gene

    Popplewell, L., Marsh, J., Kymalainen, H., Yanez, R. & Dickson, J., 15 May 2013, Human Gene Therapy. Mary Ann Liebert Inc., Vol. 24. p. A21 1 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  30. 2012
  31. Published

    Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases

    Daboussi, F., Zaslavskiy, M., Poirot, L., Loperfido, M., Gouble, A., Guyot, V., Leduc, S., Galetto, R., Grizot, S., Oficjalska, D., Perez, C., Delacôte, F., Dupuy, A., Chion-Sotinel, I., Le Clerre, D., Lebuhotel, C., Danos, O., Lemaire, F., Oussedik, K., Cédrone, F. & 11 others, Epinat, J-C., Smith, J., Yáñez (or Yáñez-Muñoz), R. J., Dickson, G., Popplewell, L., Koo, T., Vandendriessche, T., Chuah, M. K., Duclert, A., Duchateau, P. & Pâques, F., 2012, In : Nucleic Acids Research.

    Research output: Contribution to journalArticle

  32. Published

    Dual Myostatin and Dystrophin Exon Skipping by Morpholino Nucleic Acid Oligomers Conjugated to a Cell-penetrating Peptide Is a Promising Therapeutic Strategy for the Treatment of Duchenne Muscular Dystrophy

    Malerba, A., Kang, J. K., McClorey, G., Saleh, A. F., Popplewell, L., Gait, M. J., Wood, M. J. & Dickson, G., 2012, In : Molecular therapy. Nucleic acids. 1, p. e62

    Research output: Contribution to journalArticle

  33. Published

    Genetic Therapeutic Approaches for Duchenne Muscular Dystrophy

    Foster, H., Popplewell, L. J. & Dickson, G., 2012, In : Human Gene Therapy.

    Research output: Contribution to journalLiterature review

  34. Published

    Novel cationic carotenoid lipids as delivery vectors of antisense oligonucleotides for exon skipping in duchenne muscular dystrophy

    Popplewell, L. J., Abu-Dayya, A., Khana, T., Flinterman, M., Khalique, N. A., Raju, L., Opstad, C. L., Sliwka, H-R., Partali, V., Dickson, G. & Pungente, M. D., 2012, In : Molecules. 17, 2, p. 1138-48 11 p.

    Research output: Contribution to journalArticle

  35. Published

    Optimizing antisense oligonucleotides using phosphorodiamidate morpholino oligomers

    Popplewell, L. J., Malerba, A. & Dickson, G., 2012, In : Methods in Molecular Biology. 867, p. 143-67 25 p.

    Research output: Contribution to journalArticle

  36. 2011
  37. Published

    β-catenin as a potential key target for tumor suppression

    Fu, Y., Zheng, S., An, N., Athanasopoulos, T., Popplewell, L., Liang, A., Li, K., Hu, C. & Zhu, Y., 1 Oct 2011, In : International journal of cancer. Journal international du cancer. 129, 7, p. 1541-51 11 p.

    Research output: Contribution to journalReview article

  38. Published
  39. Published
  40. Published

    Bioinformatic and Functional Optimization of Antisense Phosphorodiamidate Morpholino Oligomers (PMOs) for Therapeutic Modulation of RNA Splicing in Muscle

    Popplewell, L. J., Graham, I. R., Malerba, A. & Dickson, G., 2011, In : Methods in Molecular Biology. 709, p. 153-78 26 p.

    Research output: Contribution to journalArticle

  41. Published
  42. 2010
  43. Published

    Antisense Oligonucleotide-Induced Multiexon Skipping in Duchenne Muscular Dystrophy

    Popplewell, L. J. & Dickson, G., Apr 2010, In : Human Gene Therapy. 21, 4, p. 507-508 2 p.

    Research output: Contribution to journalMeeting abstract

  44. Published

    Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials

    Popplewell, L. J., Adkin, C., Arechavala-Gomeza, V., Aartsma-Rus, A., de Winter, C. L., Wilton, S. D., Morgan, J. E., Muntoni, F., Graham, I. R. & Dickson, G., 2010, In : Neuromuscular disorders. 20, 2, p. 102-10 9 p.

    Research output: Contribution to journalArticle

  45. 2009
  46. Published

    Local restoration of dystrophin expression with the morpholino oligomer AVI-4658 in Duchenne muscular dystrophy: a single-blind, placebo-controlled, dose-escalation, proof-of-concept study

    Kinali, M., Arechavala-Gomeza, V., Feng, L., Cirak, S., Hunt, D., Adkin, C., Guglieri, M., Ashton, E., Abbs, S., Nihoyannopoulos, P., Garralda, M. E., Rutherford, M., McCulley, C., Popplewell, L., Graham, I. R., Dickson, G., Wood, M. J. A., Wells, D. J., Wilton, S. D., Kole, R. & 5 others, Straub, V., Bushby, K., Sewry, C., Morgan, J. E. & Muntoni, F., Oct 2009, In : Lancet Neurology. 8, 10, p. 918-928 11 p.

    Research output: Contribution to journalArticle

  47. Published

    Gene therapy for muscular dystrophy: current progress and future prospects

    Trollet, C., Athanasopoulos, T., Popplewell, L., Malerba, A. & Dickson, G., Jul 2009, In : Expert Opinion on Biological Therapy. 9, 7, p. 849-866 18 p.

    Research output: Contribution to journalLiterature review

  48. Published

    Design of phosphorodiamidate morpholino oligomers (PMOs) for the induction of exon skipping of the human DMD gene

    Popplewell, L. J., Trollet, C., Dickson, G. & Graham, I. R., 2009, In : Molecular Therapy. 17, 3, p. 554-61 8 p.

    Research output: Contribution to journalArticle

  49. 2007
  50. Published

    Comparative analysis of antisense oligonucleotide sequences for targeted skipping of Exon 51 during dystrophin Pre-mRNA splicing in human muscle

    Arechavala-Gomeza, V., Graham, I. R., Popplewell, L. J., Adams, A. M., Aartsma-Rus, A., Kinali, M., Morgan, J. E., Van Deutekom, J. C., Wilton, S. D., Dickson, G. & Muntoni, F., Sep 2007, In : Human Gene Therapy. 18, 9, p. 798-810 13 p.

    Research output: Contribution to journalArticle

  51. 1999
  52. Published

    Dystrophic phenotype induced in vitro by antibody blockade of muscle alpha-dystroglycan-laminin interaction

    Brown, S. C., Fassati, A., Popplewell, L., Page, A. M., Henry, M. D., Campbell, K. P. & Dickson, G., 1999, In : Journal of Cell Science. 112 ( Pt 2), p. 209-16 8 p.

    Research output: Contribution to journalArticle