Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan

Masaaki  Niino; Toshiyuki Fukazawa; Jun-ichi Kira; Tatsusada Okuno; Masahiro Mori; Nobuo  Sanjo; Takashi Ohashi; Hikoaki Fukaura; Juichi Fujimori; Yuko Shimizu; Nobuhiro Mifune; Yusei Miyazaki; Eri Takahashi; Seiji Kikuchi; Dawn Langdon; Ralph Benedict; Makoto Matsui

doi:10.1177/2055217317748972

Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan

Masaaki Niino, Toshiyuki Fukazawa, Jun-ichi Kira, Tatsusada Okuno, Masahiro Mori, Nobuo Sanjo, Takashi Ohashi, Hikoaki Fukaura, Juichi Fujimori, Yuko Shimizu, Nobuhiro Mifune, Yusei Miyazaki, Eri Takahashi, Seiji Kikuchi, Dawn Langdon, Ralph Benedict, Makoto Matsui

Research output: Contribution to journal › Article › peer-review

Abstract

Background

The Brief International Cognitive Assessment for MS (BICAMS) is a practical battery for measuring cognitive function in multiple sclerosis (MS).

Objectives

We aimed to validate a Japanese version of the BICAMS in patients with MS and healthy controls.

Methods

The Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-Second Edition (CVLT2) and the Brief Visuospatial Memory Test Revised (BVMTR) were administered to 156 patients with MS and 126 healthy controls (HCs). The BICAMS was re-administered in a subset of 27 MS patients and 30 HCs.

Results

The mean (±SD) raw scores in the MS and HC groups were as follows: SDMT: MS 47.9 ± 14.0, HC 61.0 ± 9.5; CVLT2: MS 48.6 ± 12.6, HC 55.7 ± 10.5; BVMTR: MS 23.5 ± 8.4, HC 28.3 ± 5.4, respectively, and significant differences were found between the two groups on all tests (p < 0.0001). Cohen’s d values were 1.07, 0.60, and 0.67 in SDMT, CVLT2, and BVMTR, respectively. The test-retest reliability coefficients for each test were as follows: SDMT: r = 0.93; CVLT2: r = 0.82; and BVMTR: r = 0.77 (p < 0.0001).

Conclusions

This study provides results that support the reliability and validity of the BICAMS in Japan.

Original language	English
Pages (from-to)	1-8
Number of pages	8
Journal	Multiple Sclerosis Journal: Experimental, Translational and Clinical
Volume	3
Issue number	4
DOIs	https://doi.org/10.1177/2055217317748972
Publication status	Published - 26 Dec 2017

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10.1177/2055217317748972Licence: CC BY-NC

Cite this

Niino, M., Fukazawa, T., Kira, J., Okuno, T., Mori, M., Sanjo, N., Ohashi, T., Fukaura, H., Fujimori, J., Shimizu, Y., Mifune, N., Miyazaki, Y., Takahashi, E., Kikuchi, S., Langdon, D., Benedict, R., & Matsui, M. (2017). Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan. Multiple Sclerosis Journal: Experimental, Translational and Clinical, 3(4), 1-8. https://doi.org/10.1177/2055217317748972

@article{a25b7318bdfc4e8b9ea78d66b457d619,

title = "Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan",

abstract = "BackgroundThe Brief International Cognitive Assessment for MS (BICAMS) is a practical battery for measuring cognitive function in multiple sclerosis (MS).ObjectivesWe aimed to validate a Japanese version of the BICAMS in patients with MS and healthy controls.MethodsThe Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-Second Edition (CVLT2) and the Brief Visuospatial Memory Test Revised (BVMTR) were administered to 156 patients with MS and 126 healthy controls (HCs). The BICAMS was re-administered in a subset of 27 MS patients and 30 HCs.ResultsThe mean (±SD) raw scores in the MS and HC groups were as follows: SDMT: MS 47.9 ± 14.0, HC 61.0 ± 9.5; CVLT2: MS 48.6 ± 12.6, HC 55.7 ± 10.5; BVMTR: MS 23.5 ± 8.4, HC 28.3 ± 5.4, respectively, and significant differences were found between the two groups on all tests (p < 0.0001). Cohen{\textquoteright}s d values were 1.07, 0.60, and 0.67 in SDMT, CVLT2, and BVMTR, respectively. The test-retest reliability coefficients for each test were as follows: SDMT: r = 0.93; CVLT2: r = 0.82; and BVMTR: r = 0.77 (p < 0.0001).ConclusionsThis study provides results that support the reliability and validity of the BICAMS in Japan.",

author = "Masaaki Niino and Toshiyuki Fukazawa and Jun-ichi Kira and Tatsusada Okuno and Masahiro Mori and Nobuo Sanjo and Takashi Ohashi and Hikoaki Fukaura and Juichi Fujimori and Yuko Shimizu and Nobuhiro Mifune and Yusei Miyazaki and Eri Takahashi and Seiji Kikuchi and Dawn Langdon and Ralph Benedict and Makoto Matsui",

year = "2017",

month = dec,

day = "26",

doi = "10.1177/2055217317748972",

language = "English",

volume = "3",

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journal = "Multiple Sclerosis Journal: Experimental, Translational and Clinical",

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Niino, M, Fukazawa, T, Kira, J, Okuno, T, Mori, M, Sanjo, N, Ohashi, T, Fukaura, H, Fujimori, J, Shimizu, Y, Mifune, N, Miyazaki, Y, Takahashi, E, Kikuchi, S, Langdon, D, Benedict, R & Matsui, M 2017, 'Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan', Multiple Sclerosis Journal: Experimental, Translational and Clinical, vol. 3, no. 4, pp. 1-8. https://doi.org/10.1177/2055217317748972

TY - JOUR

T1 - Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan

AU - Niino, Masaaki

AU - Fukazawa, Toshiyuki

AU - Kira, Jun-ichi

AU - Okuno, Tatsusada

AU - Mori, Masahiro

AU - Sanjo, Nobuo

AU - Ohashi, Takashi

AU - Fukaura, Hikoaki

AU - Fujimori, Juichi

AU - Shimizu, Yuko

AU - Mifune, Nobuhiro

AU - Miyazaki, Yusei

AU - Takahashi, Eri

AU - Kikuchi, Seiji

AU - Langdon, Dawn

AU - Benedict, Ralph

AU - Matsui, Makoto

PY - 2017/12/26

Y1 - 2017/12/26

N2 - BackgroundThe Brief International Cognitive Assessment for MS (BICAMS) is a practical battery for measuring cognitive function in multiple sclerosis (MS).ObjectivesWe aimed to validate a Japanese version of the BICAMS in patients with MS and healthy controls.MethodsThe Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-Second Edition (CVLT2) and the Brief Visuospatial Memory Test Revised (BVMTR) were administered to 156 patients with MS and 126 healthy controls (HCs). The BICAMS was re-administered in a subset of 27 MS patients and 30 HCs.ResultsThe mean (±SD) raw scores in the MS and HC groups were as follows: SDMT: MS 47.9 ± 14.0, HC 61.0 ± 9.5; CVLT2: MS 48.6 ± 12.6, HC 55.7 ± 10.5; BVMTR: MS 23.5 ± 8.4, HC 28.3 ± 5.4, respectively, and significant differences were found between the two groups on all tests (p < 0.0001). Cohen’s d values were 1.07, 0.60, and 0.67 in SDMT, CVLT2, and BVMTR, respectively. The test-retest reliability coefficients for each test were as follows: SDMT: r = 0.93; CVLT2: r = 0.82; and BVMTR: r = 0.77 (p < 0.0001).ConclusionsThis study provides results that support the reliability and validity of the BICAMS in Japan.

AB - BackgroundThe Brief International Cognitive Assessment for MS (BICAMS) is a practical battery for measuring cognitive function in multiple sclerosis (MS).ObjectivesWe aimed to validate a Japanese version of the BICAMS in patients with MS and healthy controls.MethodsThe Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-Second Edition (CVLT2) and the Brief Visuospatial Memory Test Revised (BVMTR) were administered to 156 patients with MS and 126 healthy controls (HCs). The BICAMS was re-administered in a subset of 27 MS patients and 30 HCs.ResultsThe mean (±SD) raw scores in the MS and HC groups were as follows: SDMT: MS 47.9 ± 14.0, HC 61.0 ± 9.5; CVLT2: MS 48.6 ± 12.6, HC 55.7 ± 10.5; BVMTR: MS 23.5 ± 8.4, HC 28.3 ± 5.4, respectively, and significant differences were found between the two groups on all tests (p < 0.0001). Cohen’s d values were 1.07, 0.60, and 0.67 in SDMT, CVLT2, and BVMTR, respectively. The test-retest reliability coefficients for each test were as follows: SDMT: r = 0.93; CVLT2: r = 0.82; and BVMTR: r = 0.77 (p < 0.0001).ConclusionsThis study provides results that support the reliability and validity of the BICAMS in Japan.

U2 - 10.1177/2055217317748972

DO - 10.1177/2055217317748972

M3 - Article

VL - 3

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EP - 8

JO - Multiple Sclerosis Journal: Experimental, Translational and Clinical

JF - Multiple Sclerosis Journal: Experimental, Translational and Clinical

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