Validation of the Brief International Cognitive Assessment for Multiple Sclerosis in Japan

Masaaki Niino, Toshiyuki Fukazawa, Jun-ichi Kira, Tatsusada Okuno, Masahiro Mori, Nobuo Sanjo, Takashi Ohashi, Hikoaki Fukaura, Juichi Fujimori, Yuko Shimizu, Nobuhiro Mifune, Yusei Miyazaki, Eri Takahashi, Seiji Kikuchi, Dawn Langdon, Ralph Benedict, Makoto Matsui

Research output: Contribution to journalArticlepeer-review

Abstract

Background

The Brief International Cognitive Assessment for MS (BICAMS) is a practical battery for measuring cognitive function in multiple sclerosis (MS).

Objectives

We aimed to validate a Japanese version of the BICAMS in patients with MS and healthy controls.

Methods

The Symbol Digit Modalities Test (SDMT), the California Verbal Learning Test-Second Edition (CVLT2) and the Brief Visuospatial Memory Test Revised (BVMTR) were administered to 156 patients with MS and 126 healthy controls (HCs). The BICAMS was re-administered in a subset of 27 MS patients and 30 HCs.

Results

The mean (±SD) raw scores in the MS and HC groups were as follows: SDMT: MS 47.9 ± 14.0, HC 61.0 ± 9.5; CVLT2: MS 48.6 ± 12.6, HC 55.7 ± 10.5; BVMTR: MS 23.5 ± 8.4, HC 28.3 ± 5.4, respectively, and significant differences were found between the two groups on all tests (p < 0.0001). Cohen’s d values were 1.07, 0.60, and 0.67 in SDMT, CVLT2, and BVMTR, respectively. The test-retest reliability coefficients for each test were as follows: SDMT: r = 0.93; CVLT2: r = 0.82; and BVMTR: r = 0.77 (p < 0.0001).

Conclusions

This study provides results that support the reliability and validity of the BICAMS in Japan.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalMultiple Sclerosis Journal: Experimental, Translational and Clinical
Volume3
Issue number4
DOIs
Publication statusPublished - 26 Dec 2017

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