The role of the cerebellum in multiple sclerosis—150 years after Charcot

Katrin Parmar; Christine  Stadelmann; Maria A Rocca; Egidio D'Angelo; Marcus D'Souza; Jessica Burggraaff; Christiane Wegner; Jaume Sastre-Garriga; Alonso Barrantes-Freer; Jonas Dorn; Bernard M J Uitdehaag; Xavier Montalban; Jens Wuerfel; Christian Enzinger; Alex Rovira; Mar Tintore; Massimo Filippi; Ludwig Kappos; Till Sprenger

doi:10.1016/j.neubiorev.2018.02.012

The role of the cerebellum in multiple sclerosis—150 years after Charcot

Katrin Parmar, Christine Stadelmann, Maria A Rocca, Egidio D'Angelo, Marcus D'Souza, Jessica Burggraaff, Christiane Wegner, Jaume Sastre-Garriga, Alonso Barrantes-Freer, Jonas Dorn, Bernard M J Uitdehaag, Xavier Montalban, Jens Wuerfel, Christian Enzinger, Alex Rovira, Mar Tintore, Massimo Filippi, Ludwig Kappos, Till Sprenger

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Abstract

Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in
MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

Original language	English
Pages (from-to)	85-98
Number of pages	14
Journal	Neuroscience and biobehavioral reviews
Volume	89
Early online date	23 Feb 2018
DOIs	https://doi.org/10.1016/j.neubiorev.2018.02.012
Publication status	Published - Jun 2018

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10.1016/j.neubiorev.2018.02.012

Accepted ManuscriptAccepted author manuscript, 843 KBLicence: CC BY-NC-ND

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Parmar, K., Stadelmann, C., Rocca, M. A., D'Angelo, E., D'Souza, M., Burggraaff, J., Wegner, C., Sastre-Garriga, J., Barrantes-Freer, A., Dorn, J., Uitdehaag, B. M. J., Montalban, X., Wuerfel, J., Enzinger, C., Rovira, A., Tintore, M., Filippi, M., Kappos, L., & Sprenger, T. (2018). The role of the cerebellum in multiple sclerosis—150 years after Charcot. Neuroscience and biobehavioral reviews, 89, 85-98. https://doi.org/10.1016/j.neubiorev.2018.02.012

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title = "The role of the cerebellum in multiple sclerosis—150 years after Charcot",

abstract = "Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement inMS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.",

author = "Katrin Parmar and Christine Stadelmann and Rocca, {Maria A} and Dawn Langdon and Egidio D'Angelo and Marcus D'Souza and Jessica Burggraaff and Christiane Wegner and Jaume Sastre-Garriga and Alonso Barrantes-Freer and Jonas Dorn and Uitdehaag, {Bernard M J} and Xavier Montalban and Jens Wuerfel and Christian Enzinger and Alex Rovira and Mar Tintore and Massimo Filippi and Ludwig Kappos and Till Sprenger",

year = "2018",

month = jun,

doi = "10.1016/j.neubiorev.2018.02.012",

language = "English",

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Parmar, K, Stadelmann, C, Rocca, MA, D'Angelo, E, D'Souza, M, Burggraaff, J, Wegner, C, Sastre-Garriga, J, Barrantes-Freer, A, Dorn, J, Uitdehaag, BMJ, Montalban, X, Wuerfel, J, Enzinger, C, Rovira, A, Tintore, M, Filippi, M, Kappos, L & Sprenger, T 2018, 'The role of the cerebellum in multiple sclerosis—150 years after Charcot', Neuroscience and biobehavioral reviews, vol. 89, pp. 85-98. https://doi.org/10.1016/j.neubiorev.2018.02.012

TY - JOUR

T1 - The role of the cerebellum in multiple sclerosis—150 years after Charcot

AU - Parmar, Katrin

AU - Stadelmann, Christine

AU - Rocca, Maria A

AU - Langdon, Dawn

AU - D'Angelo, Egidio

AU - D'Souza, Marcus

AU - Burggraaff, Jessica

AU - Wegner, Christiane

AU - Sastre-Garriga, Jaume

AU - Barrantes-Freer, Alonso

AU - Dorn, Jonas

AU - Uitdehaag, Bernard M J

AU - Montalban, Xavier

AU - Wuerfel, Jens

AU - Enzinger, Christian

AU - Rovira, Alex

AU - Tintore, Mar

AU - Filippi, Massimo

AU - Kappos, Ludwig

AU - Sprenger, Till

PY - 2018/6

Y1 - 2018/6

N2 - Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement inMS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

AB - Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement inMS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

UR - https://authors.elsevier.com/a/1WuilY3M3IVKR

U2 - 10.1016/j.neubiorev.2018.02.012

DO - 10.1016/j.neubiorev.2018.02.012

M3 - Article

SN - 0149-7634

VL - 89

SP - 85

EP - 98

JO - Neuroscience and biobehavioral reviews

JF - Neuroscience and biobehavioral reviews

ER -

The role of the cerebellum in multiple sclerosis—150 years after Charcot

Abstract

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