Structural features of the glutamate binding site in recombinant NR1/NR2A N-methyl-D-aspartate receptors determined by site-directed mutagenesis and molecular modeling

  • P. E. Chen
  • , M. T. Geballe
  • , P. J. Stansfeld
  • , A. R. Johnston
  • , H. Yuan
  • , A. L. Jacob
  • , J. P. Snyder
  • , S. F. Traynelis
  • , D. J. Wyllie

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1470-84
Number of pages15
JournalMolecular Pharmacology
Volume67
Issue number5
Publication statusPublished - 2005

Keywords

  • Amino Acid Sequence Animals Binding Sites/drug effects/physiology Dose-Response Relationship, Drug Excitatory Amino Acid Agonists/metabolism/pharmacology Female *Models, Molecular Molecular Sequence Data Mutagenesis, Site-Directed/drug effects/*physiology Receptors, N-Methyl-D-Aspartate/chemistry/genetics/*metabolism Recombinant Proteins/chemistry/genetics/metabolism Xenopus laevis

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