Role of inflammatory cells and toll-like receptors in atherosclerosis

Anusha N Seneviratne, Claudia Monaco

Research output: Contribution to journalReview articlepeer-review


The primary cause of cerebrovascular disease is atherosclerosis, to which many factors contribute. At first many saw atherosclerosis as a lipid-driven disease. Recently inflammation has appeared as a significant factor in the disease. Innate immune cells, for example monocytes and macrophages, are important in atherosclerosis. Toll-like receptors (TLRs) are the best-studied family of receptor in the immune system. TLR engagement with their ligands stimulates pro-inflammatory cytokine production and foam cell generation. Recently certain TLRs have shown a protective role in atherosclerosis. In this review, we analyse innate immunity, focusing on TLR signalling and macrophages, in atherosclerosis and acute cerebrovascular complications, and thereby discuss their potential as therapeutic targets.

Original languageEnglish
Pages (from-to)146-60
Number of pages15
JournalCurrent vascular pharmacology
Issue number2
Publication statusPublished - 2015
Externally publishedYes


  • Animals
  • Anti-Inflammatory Agents/therapeutic use
  • Atherosclerosis/drug therapy
  • Cerebrovascular Disorders/drug therapy
  • Cytokines/immunology
  • Humans
  • Immunity, Innate/drug effects
  • Inflammation/drug therapy
  • Inflammation Mediators/metabolism
  • Ligands
  • Macrophages/drug effects
  • Molecular Targeted Therapy
  • Risk Factors
  • Signal Transduction
  • Toll-Like Receptors/antagonists & inhibitors

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