Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones

Thomas H Hutson; Edmund Foster; John M Dawes; Robert Hindges; Rafael J. Yáñez (or Yáñez-Muñoz); Lawrence D F Moon

doi:10.1002/jgm.2626

Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones

Thomas H Hutson, Edmund Foster, John M Dawes, Robert Hindges, Rafael J. Yáñez (or Yáñez-Muñoz) , Lawrence D F Moon

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Original language	English
Pages (from-to)	299-315
Number of pages	17
Journal	Journal of Gene Medicine
Volume	14
Issue number	5
Early online date	12 Apr 2012
DOIs	https://doi.org/10.1002/jgm.2626
Publication status	Published - 2012

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10.1002/jgm.2626

http://www.ncbi.nlm.nih.gov/pubmed/22499506

Cite this

@article{33fa97c7bbcb400ab27aea889881bbf9,

title = "Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones",

author = "Hutson, {Thomas H} and Edmund Foster and Dawes, {John M} and Robert Hindges and {Y{\'a}{\~n}ez (or Y{\'a}{\~n}ez-Mu{\~n}oz)}, {Rafael J.} and Moon, {Lawrence D F}",

note = "Copyright {\textcopyright} 2012 John Wiley & Sons, Ltd.",

year = "2012",

doi = "10.1002/jgm.2626",

language = "English",

volume = "14",

pages = "299--315",

journal = "Journal of Gene Medicine",

issn = "1521-2254",

publisher = "John Wiley and Sons Ltd",

number = "5",

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TY - JOUR

T1 - Lentiviral vectors encoding short hairpin RNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in central nervous system neurones

AU - Hutson, Thomas H

AU - Foster, Edmund

AU - Dawes, John M

AU - Hindges, Robert

AU - Yáñez (or Yáñez-Muñoz) , Rafael J.

AU - Moon, Lawrence D F

PY - 2012

Y1 - 2012

U2 - 10.1002/jgm.2626

DO - 10.1002/jgm.2626

M3 - Article

C2 - 22499506

SN - 1521-2254

VL - 14

SP - 299

EP - 315

JO - Journal of Gene Medicine

JF - Journal of Gene Medicine

IS - 5

ER -