TY - JOUR
T1 - From genetic disposition to academic achievement
T2 - The mediating role of non-cognitive skills across development
AU - Zhou, Quan
AU - Liao, Wangjingyi
AU - Allegrini, Andrea G
AU - Rimfeld, Kaili
AU - Wertz, Jasmin
AU - Morris, Tim
AU - Raffington, Laurel
AU - Plomin, Robert
AU - Malanchini, Margherita
PY - 2025/2/27
Y1 - 2025/2/27
N2 - Genetic effects on academic achievement are likely to capture environmental, developmental, and psychological processes. How these processes contribute to translating genetic dispositions into observed academic achievement remains critically under-investigated. Here, we examined the role of non-cognitive skills-e.g., motivation, attitudes and self-regulation-in mediating education-associated genetic effects on academic achievement across development. Data were collected from 5,016 children enrolled in the Twins Early Development Study at ages 7, 9, 12, and 16, as well as their parents and teachers. We found that non-cognitive skills mediated polygenic score effects on academic achievement across development, and longitudinally, accounting for up to 64% of the total effects. Within-family analyses highlighted the contribution of non-cognitive skills beyond genetic, environmental and demographic factors that are shared between siblings, accounting for up to 83% of the total mediation effect, likely reflecting evocative/active gene-environment correlation. Our results underscore the role of non-cognitive skills in academic development in how children evoke and select experiences that align with their genetic propensity.
AB - Genetic effects on academic achievement are likely to capture environmental, developmental, and psychological processes. How these processes contribute to translating genetic dispositions into observed academic achievement remains critically under-investigated. Here, we examined the role of non-cognitive skills-e.g., motivation, attitudes and self-regulation-in mediating education-associated genetic effects on academic achievement across development. Data were collected from 5,016 children enrolled in the Twins Early Development Study at ages 7, 9, 12, and 16, as well as their parents and teachers. We found that non-cognitive skills mediated polygenic score effects on academic achievement across development, and longitudinally, accounting for up to 64% of the total effects. Within-family analyses highlighted the contribution of non-cognitive skills beyond genetic, environmental and demographic factors that are shared between siblings, accounting for up to 83% of the total mediation effect, likely reflecting evocative/active gene-environment correlation. Our results underscore the role of non-cognitive skills in academic development in how children evoke and select experiences that align with their genetic propensity.
U2 - 10.1101/2025.02.27.640510
DO - 10.1101/2025.02.27.640510
M3 - Article
C2 - 40060469
SN - 2692-8205
JO - bioRxiv : the preprint server for biology
JF - bioRxiv : the preprint server for biology
ER -