Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation

Marco Nicolini; Emanuele Saitto; Ruben Emilio Jimenez Franco; Emanuele Cavalleri; Aldo Javier Galeano Alfonso; Dario Malchiodi; Alberto Paccanaro; Peter N. Robinson; Elena Casiraghi; Giorgio Valentini

doi:10.1016/j.csbj.2025.03.037

Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation

Marco Nicolini
, Emanuele Saitto
, Ruben Emilio Jimenez Franco
, Emanuele Cavalleri
, Aldo Javier Galeano Alfonso
, Dario Malchiodi
, Alberto Paccanaro
, Peter N. Robinson
, Elena Casiraghi
, Giorgio Valentini

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1318-1334
Number of pages	17
Journal	Computational and Structural Biotechnology Journal
Volume	27
Early online date	26 Mar 2025
DOIs	https://doi.org/10.1016/j.csbj.2025.03.037
Publication status	E-pub ahead of print - 26 Mar 2025

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10.1016/j.csbj.2025.03.037Licence: CC BY-NC-ND

Cite this

Nicolini, M., Saitto, E., Jimenez Franco, R. E., Cavalleri, E., Galeano Alfonso, A. J., Malchiodi, D., Paccanaro, A., Robinson, P. N., Casiraghi, E., & Valentini, G. (2025). Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation. Computational and Structural Biotechnology Journal, 27, 1318-1334. Advance online publication. https://doi.org/10.1016/j.csbj.2025.03.037

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title = "Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation",

author = "Marco Nicolini and Emanuele Saitto and \{Jimenez Franco\}, \{Ruben Emilio\} and Emanuele Cavalleri and \{Galeano Alfonso\}, \{Aldo Javier\} and Dario Malchiodi and Alberto Paccanaro and Robinson, \{Peter N.\} and Elena Casiraghi and Giorgio Valentini",

year = "2025",

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doi = "10.1016/j.csbj.2025.03.037",

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T1 - Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation

AU - Nicolini, Marco

AU - Saitto, Emanuele

AU - Jimenez Franco, Ruben Emilio

AU - Cavalleri, Emanuele

AU - Galeano Alfonso, Aldo Javier

AU - Malchiodi, Dario

AU - Paccanaro, Alberto

AU - Robinson, Peter N.

AU - Casiraghi, Elena

AU - Valentini, Giorgio

PY - 2025/3/26

Y1 - 2025/3/26

U2 - 10.1016/j.csbj.2025.03.037

DO - 10.1016/j.csbj.2025.03.037

M3 - Article

VL - 27

SP - 1318

EP - 1334

JO - Computational and Structural Biotechnology Journal

JF - Computational and Structural Biotechnology Journal

ER -