Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation

Marco Nicolini; Emanuele Saitto; Ruben Emilio Jimenez Franco; Emanuele Cavalleri; Aldo Javier Galeano Alfonso; Dario Malchiodi; Alberto Paccanaro; Peter N. Robinson; Elena Casiraghi; Giorgio Valentini

doi:10.1016/j.csbj.2025.03.037

Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation

Marco Nicolini, Emanuele Saitto, Ruben Emilio Jimenez Franco, Emanuele Cavalleri, Aldo Javier Galeano Alfonso, Dario Malchiodi, Alberto Paccanaro, Peter N. Robinson, Elena Casiraghi, Giorgio Valentini

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1318-1334
Number of pages	17
Journal	Computational and Structural Biotechnology Journal
Volume	27
Early online date	26 Mar 2025
DOIs	https://doi.org/10.1016/j.csbj.2025.03.037
Publication status	E-pub ahead of print - 26 Mar 2025

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10.1016/j.csbj.2025.03.037Licence: CC BY-NC-ND

Cite this

Nicolini, M., Saitto, E., Jimenez Franco, R. E., Cavalleri, E., Galeano Alfonso, A. J., Malchiodi, D., Paccanaro, A., Robinson, P. N., Casiraghi, E., & Valentini, G. (2025). Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation. Computational and Structural Biotechnology Journal, 27, 1318-1334. Advance online publication. https://doi.org/10.1016/j.csbj.2025.03.037

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title = "Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation",

author = "Marco Nicolini and Emanuele Saitto and {Jimenez Franco}, {Ruben Emilio} and Emanuele Cavalleri and {Galeano Alfonso}, {Aldo Javier} and Dario Malchiodi and Alberto Paccanaro and Robinson, {Peter N.} and Elena Casiraghi and Giorgio Valentini",

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T1 - Fine-tuning of conditional Transformers improves in silico enzyme prediction and generation

AU - Nicolini, Marco

AU - Saitto, Emanuele

AU - Jimenez Franco, Ruben Emilio

AU - Cavalleri, Emanuele

AU - Galeano Alfonso, Aldo Javier

AU - Malchiodi, Dario

AU - Paccanaro, Alberto

AU - Robinson, Peter N.

AU - Casiraghi, Elena

AU - Valentini, Giorgio

PY - 2025/3/26

Y1 - 2025/3/26

U2 - 10.1016/j.csbj.2025.03.037

DO - 10.1016/j.csbj.2025.03.037

M3 - Article

VL - 27

SP - 1318

EP - 1334

JO - Computational and Structural Biotechnology Journal

JF - Computational and Structural Biotechnology Journal

ER -