Drug cocktail selection for the treatment of chagas disease: A multi-objective approach

Mateo Torres Bobadilla, Juan Caceres Silva, Rubén Jimenez, Víctor Yubero, Celeste Vega, Miriam Rolón, Luca Cernuzzi, Benjamín Barán, Alberto Paccanaro

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Chagas disease is a parasitic disease, endemic in South America. As of today, there is no effective treatment in its chronic stage. We have recently identified 134 FDA approved drugs with potential antitrypanosomal activity. In this paper, we propose a novel method for selecting combinations of drugs (drug cocktails), to provide a more effective treatment against Chagas disease. We define three measures to evaluate the predicted performance of a cocktail, establishing in this way a mathematical foundation for its analysis. This allows us to model the drug cocktail selection as a multi-objective optimisation problem, that we show can be solved efficiently with state-of-the-art evolutionary algorithms. Our analysis retrieves 57 drug cocktails containing between 2 and 6 drugs. We discuss the improvement of the cocktail selection given by our method, and the application of this approach to the identification of cocktails against other parasitic diseases.
Original languageEnglish
Title of host publicationSLIOIA - Simposio Latinoamericano de Investigación de Operaciones e Inteligencia Artificial 2017
Number of pages5
ISBN (Electronic)978-1-5386-3057-0
Publication statusPublished - 21 Dec 2017

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