Diagnostic accuracy of autofluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma

Radu A. Boitor; Sandeep Varma; Ashish Sharma; Sunita  Odedra; Somaia Elsheikh; Karim Eldib; Anand Patel; Alexey Koloydenko; Sonia Gran; Koen De Winne; Senada Koljenovic; Hywel C. Williams; Ioan Notingher

doi:10.1093/bjd/ljae196

Diagnostic accuracy of autofluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma

Radu A. Boitor, Sandeep Varma, Ashish Sharma, Sunita Odedra, Somaia Elsheikh, Karim Eldib, Anand Patel, Alexey Koloydenko, Sonia Gran, Koen De Winne, Senada Koljenovic, Hywel C. Williams, Ioan Notingher

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Abstract

Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma (BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohs surgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130 patients) shows that with improvement in tissue processing, the AF-Raman instrument is viable technique for intra-operative assessment of surgical margins.

Original language	English
Number of pages	18
Journal	British Journal of Dermatology
Early online date	13 May 2024
DOIs	https://doi.org/10.1093/bjd/ljae196
Publication status	E-pub ahead of print - 13 May 2024

Keywords

Mohs, Basal cell carcinoma, Evidence-based dermatology

Access to Document

10.1093/bjd/ljae196Licence: CC BY

Final published versionFinal published version, 2.02 MBLicence: CC BY

Cite this

Boitor, R. A., Varma, S., Sharma, A., Odedra, S., Elsheikh, S., Eldib, K., Patel, A., Koloydenko, A., Gran, S., De Winne, K., Koljenovic, S., Williams, H. C., & Notingher, I. (2024). Diagnostic accuracy of autofluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma. British Journal of Dermatology. Advance online publication. https://doi.org/10.1093/bjd/ljae196

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abstract = "Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma (BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohs surgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130 patients) shows that with improvement in tissue processing, the AF-Raman instrument is viable technique for intra-operative assessment of surgical margins.",

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Boitor, RA, Varma, S, Sharma, A, Odedra, S, Elsheikh, S, Eldib, K, Patel, A, Koloydenko, A, Gran, S, De Winne, K, Koljenovic, S, Williams, HC & Notingher, I 2024, 'Diagnostic accuracy of autofluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma', British Journal of Dermatology. https://doi.org/10.1093/bjd/ljae196

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T1 - Diagnostic accuracy of autofluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma

AU - Boitor, Radu A.

AU - Varma, Sandeep

AU - Sharma, Ashish

AU - Odedra, Sunita

AU - Elsheikh, Somaia

AU - Eldib, Karim

AU - Patel, Anand

AU - Koloydenko, Alexey

AU - Gran, Sonia

AU - De Winne, Koen

AU - Koljenovic, Senada

AU - Williams, Hywel C.

AU - Notingher, Ioan

PY - 2024/5/13

Y1 - 2024/5/13

N2 - Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma (BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohs surgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130 patients) shows that with improvement in tissue processing, the AF-Raman instrument is viable technique for intra-operative assessment of surgical margins.

AB - Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma (BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohs surgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130 patients) shows that with improvement in tissue processing, the AF-Raman instrument is viable technique for intra-operative assessment of surgical margins.

KW - Mohs, Basal cell carcinoma, Evidence-based dermatology

U2 - 10.1093/bjd/ljae196

DO - 10.1093/bjd/ljae196

M3 - Article

JO - British Journal of Dermatology

JF - British Journal of Dermatology

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