Diagnostic accuracy of autofluorescence-Raman spectroscopy for surgical margin assessment during Mohs micrographic surgery of basal cell carcinoma

Radu A. Boitor, Sandeep Varma, Ashish Sharma, Sunita Odedra, Somaia Elsheikh, Karim Eldib, Anand Patel, Alexey Koloydenko, Sonia Gran, Koen De Winne, Senada Koljenovic, Hywel C. Williams, Ioan Notingher

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Abstract

Autofluorescence (AF)-Raman spectroscopy has been shown to identify residual basal cell carcinoma (BCC) on frozen skin specimens and fresh skin specimens immediately after excision by Mohs surgery. This first diagnostic test of accuracy of AF-Raman on 130 full-face Mohs tissue layers (130 patients) shows that with improvement in tissue processing, the AF-Raman instrument is viable technique for intra-operative assessment of surgical margins.
Original languageEnglish
Number of pages18
JournalBritish Journal of Dermatology
Early online date13 May 2024
DOIs
Publication statusE-pub ahead of print - 13 May 2024

Keywords

  • Mohs, Basal cell carcinoma, Evidence-based dermatology

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