Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials

Linda J Popplewell; Carl Adkin; Virginia Arechavala-Gomeza; Annemieke Aartsma-Rus; Christa L de Winter; Steve D Wilton; Jennifer E Morgan; Francesco Muntoni; Ian R Graham; George Dickson

doi:10.1016/j.nmd.2009.10.013

Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials

Linda J Popplewell, Carl Adkin, Virginia Arechavala-Gomeza, Annemieke Aartsma-Rus, Christa L de Winter, Steve D Wilton, Jennifer E Morgan, Francesco Muntoni, Ian R Graham, George Dickson

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	102-10
Number of pages	9
Journal	Neuromuscular disorders
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.nmd.2009.10.013
Publication status	Published - 2010

Keywords

Animals
Base Sequence
Cells, Cultured
Disease Models, Animal
Dystrophin
Exons
Gene Expression Regulation
Gene Targeting
Gene Therapy
Humans
Male
Mice
Mice, Transgenic
Morpholines
Muscular Dystrophy, Duchenne
Mutation
Oligonucleotides, Antisense
Transcription, Genetic

Access to Document

10.1016/j.nmd.2009.10.013

Cite this

Popplewell, L. J., Adkin, C., Arechavala-Gomeza, V., Aartsma-Rus, A., de Winter, C. L., Wilton, S. D., Morgan, J. E., Muntoni, F., Graham, I. R., & Dickson, G. (2010). Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials. Neuromuscular disorders, 20(2), 102-10. https://doi.org/10.1016/j.nmd.2009.10.013

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title = "Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials",

keywords = "Animals, Base Sequence, Cells, Cultured, Disease Models, Animal, Dystrophin, Exons, Gene Expression Regulation, Gene Targeting, Gene Therapy, Humans, Male, Mice, Mice, Transgenic, Morpholines, Muscular Dystrophy, Duchenne, Mutation, Oligonucleotides, Antisense, Transcription, Genetic",

author = "Popplewell, {Linda J} and Carl Adkin and Virginia Arechavala-Gomeza and Annemieke Aartsma-Rus and {de Winter}, {Christa L} and Wilton, {Steve D} and Morgan, {Jennifer E} and Francesco Muntoni and Graham, {Ian R} and George Dickson",

year = "2010",

doi = "10.1016/j.nmd.2009.10.013",

language = "English",

volume = "20",

pages = "102--10",

journal = "Neuromuscular disorders",

issn = "1873-2364",

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Popplewell, LJ, Adkin, C, Arechavala-Gomeza, V, Aartsma-Rus, A, de Winter, CL, Wilton, SD, Morgan, JE, Muntoni, F, Graham, IR & Dickson, G 2010, 'Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials', Neuromuscular disorders, vol. 20, no. 2, pp. 102-10. https://doi.org/10.1016/j.nmd.2009.10.013

TY - JOUR

T1 - Comparative analysis of antisense oligonucleotide sequences targeting exon 53 of the human DMD gene: Implications for future clinical trials

AU - Popplewell, Linda J

AU - Adkin, Carl

AU - Arechavala-Gomeza, Virginia

AU - Aartsma-Rus, Annemieke

AU - de Winter, Christa L

AU - Wilton, Steve D

AU - Morgan, Jennifer E

AU - Muntoni, Francesco

AU - Graham, Ian R

AU - Dickson, George

PY - 2010

Y1 - 2010

KW - Animals

KW - Base Sequence

KW - Cells, Cultured

KW - Disease Models, Animal

KW - Dystrophin

KW - Exons

KW - Gene Expression Regulation

KW - Gene Targeting

KW - Gene Therapy

KW - Humans

KW - Male

KW - Mice

KW - Mice, Transgenic

KW - Morpholines

KW - Muscular Dystrophy, Duchenne

KW - Mutation

KW - Oligonucleotides, Antisense

KW - Transcription, Genetic

U2 - 10.1016/j.nmd.2009.10.013

DO - 10.1016/j.nmd.2009.10.013

M3 - Article

C2 - 20079639

SN - 1873-2364

VL - 20

SP - 102

EP - 110

JO - Neuromuscular disorders

JF - Neuromuscular disorders

IS - 2

ER -