Codon and mRNA sequence optimization of microdystrophin transgenes improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer

  • Helen Foster
  • , Paul S Sharp
  • , Takis Athanasopoulos
  • , Capucine Trollet
  • , Ian R Graham
  • , Keith Foster
  • , Dominic J Wells
  • , George Dickson

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1825-32
Number of pages8
JournalMolecular Therapy
Volume16
Issue number11
DOIs
Publication statusPublished - 2008

Keywords

  • Animals
  • Codon
  • Dependovirus
  • Dystrophin
  • Gene Transfer Techniques
  • Genetic Vectors
  • Humans
  • Mice
  • Mice, Inbred mdx
  • Muscular Dystrophy, Animal
  • RNA, Messenger
  • Transgenes

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