Codon and mRNA sequence optimization of microdystrophin transgenes improves expression and physiological outcome in dystrophic mdx mice following AAV2/8 gene transfer

Helen Foster, Paul S Sharp, Takis Athanasopoulos, Capucine Trollet, Ian R Graham, Keith Foster, Dominic J Wells, George Dickson

Research output: Contribution to journalArticlepeer-review

Original languageEnglish
Pages (from-to)1825-32
Number of pages8
JournalMolecular Therapy
Issue number11
Publication statusPublished - 2008


  • Animals
  • Codon
  • Dependovirus
  • Dystrophin
  • Gene Transfer Techniques
  • Genetic Vectors
  • Humans
  • Mice
  • Mice, Inbred mdx
  • Muscular Dystrophy, Animal
  • RNA, Messenger
  • Transgenes

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