We present 14 new 10Be cosmogenic nuclide exposure ages quantifying asynchronous readvances during the Antarctic Cold Reversal from glaciers in the Baker Valley region of central Patagonia. We constrain glacier and ice-dammed palaeolake dynamics using a landsystems approach, concentrating on outlet glaciers from the eastern Northern Patagonian Icefield and Monte San Lorenzo. Soler Glacier (Northern Patagonian Icefield) produced lateral moraines above Lago Bertrand from 15.1±0.7 to 14.0±0.6 ka, when it dammed the drainage of Lago General Carrera/Buenos Aires through Río Baker at a bedrock pinning point. At this time, Soler Glacier terminated into the 400 m “Deseado” level of the ice-dammed palaeolake. Later, Calluqueo Glacier (Monte San Lorenzo) deposited subaerial and subaqueous moraines in an ice-dammed palaeolake (Lago Chalenko; 350 m asl) in the Salto Valley near Cochrane at 13.0±0.6 ka. The Salto Valley glaciolacustrine landsystem includes subaqueous morainal banks, ice-scoured bedrock, glacial diamicton plastered onto valley sides, perched delta terraces, kame terraces, ice-contact fans, palaeoshorelines and subaerial push and lateral moraines. Boulders from the subaqueous Salto Moraine became exposed at 12.1±0.6 years, indicating palaeolake drainage. These data show an asynchronous advance of outlet glaciers from the NPI and Monte San Lorenzo during the Antarctic Cold Reversal. These advances occurred during a period of regional climatic cooling, but differential moraine extent and timing of advance was controlled by topography and calving processes.