Sime is a lecturer in Entrepreneurship and Innovation at the Business and Management School of the Royal Holloway University of London (RHUL). He holds a PhD in Innovation and Strategy from RHUL, an MBA, and a Master’s degree in Human Rights and Democratisation from the Institute of Advanced Legal Studies at the University of London.

Sime's research interests focus on Innovation and Technology Management, particularly the collaborative strategy of firms in high-tech industries. He approaches these phenomena from an alliance, network, and ecosystem perspective. He mainly employs econometric techniques and draws upon a diverse array of novel data sources to link networks resulting from inter-firm collaborations to firm-level outcomes. His research has been published in internationally recognized journals such as Technovation and presented at conferences such as the Wharton Science Conference, the Strategic Management Society, and the British and European Academy of Management Conference. His work was awarded the Best Paper Award at the British Academic Management Conference 2017.

Before joining the Royal Holloway University of London, Sime was the lead for Students' Enterprise and Entrepreneurship at South Bank University. He also held academic positions at De Montfort University of London, Queen Mary University of London, and the University of Montpellier in France. He is a distinguished teacher who received a distinction for his fellowship from the UK Higher Education Academy.

Sime has also been involved in several technological ventures and currently advises several start-ups in semiconductors, mobile apps, and digital marketing. He is interested in working with nascent AI, Blockchain, and Fintech entrepreneurs. He welcomes potential PhD candidates interested in Entrepreneurship, Innovation, and Strategy.