Centre of Gene and Cell Therapy

Research output

Research output per year 2010 2010 2011 2012 2013 2014 2015 2016 2017 2018 2019 2024

• 183 Article
• 16 Doctoral Thesis
• 11 Conference contribution
• 9 Review article
• 30 More
  • 6 Editorial
  • 5 Chapter
  • 3 Book
  • 3 Book/Film/Article review
  • 2 Chapter (peer-reviewed)
  • 2 Abstract
  • 2 Meeting abstract
  • 2 Literature review
  • 1 Entry for encyclopedia/dictionary
  • 1 Comment/debate
  • 1 Web publication/site
  • 1 Other contribution
  • 1 Patent

Research output per year

Research output per year

Search results

• 2024

  A systematic methodology to assess the identity of plants in historical texts: A case study based on the Byzantine pharmacy text John the Physician’s Therapeutics

  Lardos, A., Patmore, K., Allkin, R., Lazarou, R., Nesbitt, M., Scott, A. C. & Zipser, B., 25 Mar 2024, In: Journal of Ethnopharmacology. 322, 117622.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• LanDis: the disease landscape explorer

  Caniza, H., Caceres, J. J., Torres, M. & Paccanaro, A., 10 Jan 2024, (E-pub ahead of print) In: European Journal of Human Genetics.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2023

  AAV9-mediated SMN gene therapy rescues cardiac desmin but not Lamin A/C and elastin dysregulation in Smn 2B/- spinal muscular atrophy mice

  Brown, S. J., Šoltić, D., Synowsky, S. A., Shirran, S. L., Chilcott, E., Shorrock, H. K., Gillingwater, T. H., Yáñez-Muñoz, R. J., Schneider, B., Bowerman, M. & Fuller, H. R., 27 Jul 2023, In: Human Molecular Genetics. ddad121.

  Research output: Contribution to journal › Article › peer-review

  Open Access
  3 Downloads (Pure)

• An induced pluripotent stem cell-derived human blood-brain barrier (BBB) model to test the crossing by adeno-associated virus (AAV) vectors and antisense oligonucleotides

  Selvakumaran, J., Ursu, S., Bowerman, M., Lu-Nguyen, N., Wood, M. J., Malerba, A. & Yáñez-Muñoz, R. J., 4 Oct 2023, In: Biomedicines. 11, 10, 2700.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Enhanced expression of the human Survival motor neuron 1 gene from a codon-optimised cDNA transgene in vitro and in vivo

  Ali Mohammadi Nafchi, N., Chilcott, E., Brown, S., Fuller, H. R., Bowerman, M. & Yáñez-Muñoz, R. J., 15 Jun 2023, In: Gene Therapy.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  15 Downloads (Pure)

• Interpreting materia medica. A case study on Ioannes Archiatrus

  Zipser, B., Lardos, A., Lazarou, R., Allkin, R., Nesbitt, M. & Scott, A. C., 2023, (Submitted) In: Wellcome Open Research.

  Research output: Contribution to journal › Article

• Novel Metabolomic Approach for Identifying Pathology-Specific Biomarkers in Rare Diseases: A Case Study in Oculopharyngeal Muscular Dystrophy (OPMD)

  Harish, P., Malerba, A., Kroon, R., Shademan, M., van Engelan, B., Raz, V., Popplewell, L. & Snowden, S., 19 Jun 2023, In: Metabolites. 13, 6, 769.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Pharmaceutical terminology in Ancient and Medieval Time - "Andrachne", "Chrysocolla" and Others

  Zipser, B., Scott, A. C., Allkin, R., Gan, P., Lardos, A., Lazarou, R., Lev, E., Nesbitt, M. & Patmore, K., 30 Dec 2023, In: Studia Ceranea. 13, p. 715-736

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2022

  Heterogeneous Attitudinal Profiles Towards Gene Editing: Evidence From Latent Class Analysis

  Halstead, I., Boehnke, J. & Lewis, G., 24 Aug 2022, (E-pub ahead of print) In: Public Understanding of Science. 32, 2, p. 159-174 16 p.

  Research output: Contribution to journal › Article › peer-review

• Machine Learning Prediction of Side effects for Drugs in Clinical Trials

  Galeano, D. & Paccanaro, A., 19 Dec 2022, (E-pub ahead of print) In: Cell Reports Methods. 2, 12, 100358.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2021

  A new strategy to increase RNA Editing at the Q/R Site of GluA2 AMPA receptor subunits by targeting alternative splicing patterns of ADAR2

  Chaytow, H., Sethw Hassan, I., Akbar, S., Popplewell, L., Dickson, G. & Chen, P., 1 Dec 2021, In: Journal of Neuroscience Methods. 364, 109357.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  29 Downloads (Pure)

• Machine learning and network medicine approaches for drug repositioning for COVID-19

  de Siquiera Santos, S., Torres, M., Galeano Galeano, D., Sanchez, M. D. M., Cernuzzi, L. & Paccanaro, A., 9 Nov 2021, (E-pub ahead of print) In: Cell Patterns.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Protein Function Prediction for newly sequenced organisms

  Torres, M., Yang, H., Romero, A. E. & Paccanaro, A., 9 Dec 2021, In: Nature Machine Intelligence.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  165 Downloads (Pure)

• Systematic review and meta-analysis determining the benefits of in vivo genetic therapy in spinal muscular atrophy rodent models

  Chilcott, E., Muiruri, E., Hirst, T. C. & Yáñez-Muñoz, R. J., 6 Oct 2021, In: Gene Therapy.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The British Society for Gene and Cell Therapy

  Griesenbach, U. & Yáñez-Muñoz, R. J., 18 Oct 2021, In: Human Gene Therapy. 32, 19-20, p. 983-985 3 p.

  Research output: Contribution to journal › Article

  Open Access

  File
  22 Downloads (Pure)

• The Indirect Tradition of Paul of Aegina in Ioannes Archiatrus

  Zipser, B., 25 Mar 2021, In: Galenos. 14, p. 237-244 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2020

  Increased dystrophin production with golodirsen in patients with Duchenne muscular dystrophy

  on behalf of the SKIP-NMD Study Group, 5 Mar 2020, (E-pub ahead of print) In: Neurology. 94, 21, p. e2270-e2282 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Inhibition of Myostatin Reduces Collagen Deposition in a Mouse Model of Oculopharyngeal Muscular Dystrophy (OPMD) With Established Disease

  Harish, P., Forrest, L., Herath, S., Dickson, G., Malerba, A. & Popplewell, L., 5 Mar 2020, In: Frontiers in Physiology. 11, p. 1-8 8 p., 184.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• LUMI-PCR: An Illumina platform ligation-mediated PCR protocol for integration site cloning, provides molecular quantitation of integration sites

  Dawes, J. C., Webster, P., Iadarola, B., Garcia-Diaz, C., Dore, M., Bolt, B. J., Dewchand, H., Dharmalingam, G., McLatchie, A. P., Kaczor, J., Caceres, J. J., Paccanaro, A., Game, L., Parrinello, S. & Uren, A. G., 4 Feb 2020, In: Mobile DNA. 11, p. 1-16 16 p., 7.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Muscle overexpression of Klf15 via an AAV8-Spc5-12 construct does not provide benefits in spinal muscular atrophy mice

  Ahlskog, N., Hayler-Pountney, D., Krueger, A., Kubinski, S., Claus, P., Hammond, S. M., Wood, M. J. A., Yáñez-Muñoz, R. J. & Bowerman, M., 20 Apr 2020, In: Gene Therapy. p. 1-11 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Network modeling of patients’ biomolecular profiles for clinical phenotype/outcome prediction

  Gliozzo, J., Perlasca, P., Mesiti, M., Casiraghi, E., Vallacchi, V., Vergani, E., Frasca, M., Grossi, G., Petrini, A., Re, M., Paccanaro, A. & Valentini, G., 27 Feb 2020, In: Scientific Reports. 10, p. 1-15 15 p., 3612.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Predicting the Frequencies of Drug Side effects

  Galeano, D., Li, S., Gerstein, M. & Paccanaro, A., 11 Sept 2020, In: Nature Communications. 11, p. 1-14 14 p., 4575.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• The Corrected Gene Proximity map for analyzing the 3D genome organization using Hi-C data

  Ye, C., Paccanaro, A., Gerstein, M. & Yan, K-K., 29 May 2020, In: BMC Bioinformatics. 21, p. 1-18 18 p., 222.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Understanding opposition to human gene editing: A role for pathogen disgust sensitivity?

  Halstead, I. & Lewis, G. J., 18 Sept 2020, (E-pub ahead of print) In: Politics and the Life Sciences. 39, 2, p. 154-166 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  83 Downloads (Pure)
• 2019

  A pilot study to elucidate effects of artificial selection by size on the zebrafish (Danio rerio) fast skeletal muscle transcriptome

  Harish, P., Mareco, E. A. & Garcia de la serrana, D., Jul 2019, In: Comparative Biochemistry and Physiology -Part A : Molecular and Integrative Physiology. 233, p. 65-73 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  30 Downloads (Pure)

• A study to assess a novel automated electrocardiogram technology in screening for atrial fibrillation

  Sabar, M. I., Ara, F., Henderson, A., Ahmed, O., Potter, C., John, I., Mitchell, A. R. J., Yáñez-Muñoz, R. J. & Kaba, R. A., Oct 2019, In: Pacing and clinical electrophysiology : PACE. 42, 10, p. 1383-1389 7 p.

  Research output: Contribution to journal › Article › peer-review

• Carotenoid Skin Coloration Enhances Face and Body Attractiveness: A Cross-Cultural Study

  Ip, F., Lewis, G. & Lefevre, C., 29 Apr 2019, (E-pub ahead of print) In: The Quarterly Journal of Experimental Psychology. p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  92 Downloads (Pure)

• Disease gene prediction for molecularly uncharacterized diseases

  Caceres, J. & Paccanaro, A., 5 Jul 2019, In: PLoS Computational Biology. 15, 7, p. 1-14 14 p., e1007078.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• How Many Ways to Say Goodbye? The Latent Class Structure and Psychological Correlates of European Union Sentiment in a Large Sample of UK Adults

  Lewis, G. & de-Wit, L., 2 Jul 2019, In: Journal of Social and Political Psychology. 7, 1, p. 556-576 21 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Overexpression of the dopamine receptor‐interacting protein Alix/AIP1 modulates NMDA receptor‐triggered cell death

  Syed Salim, S., Nasir, J. & Chen, P., Jun 2019, In: FEBS Letters. 593, 12, p. 1381-1391 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  38 Downloads (Pure)

• Sex differences in emotion recognition: Evidence for a small overall female superiority on facial disgust

  Connolly, H., Lefevre, C., Young, A. & Lewis, G., Apr 2019, In: Emotion. 19, 3, p. 455-464 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  246 Downloads (Pure)

• The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens

  Zhou, N., Bhat, P., Torres Bobadilla, M., Paccanaro, A., Yang, H. & Romero, A. E., 19 Nov 2019, In: Genome Biology. 20, p. 1-23 23 p., 244 (2019).

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Vaccination of macaques with DNA followed by adenoviral vectors encoding SIV gag alone delays infection by repeated mucosal challenge with SIV

  Almond, N., Berry, N., Stebbings, R., Preston, M., Ham, C., Page, M., Ferguson, D., Rose, N., Li, B., Mee, E. T., Hassall, M., Stahl-Hennig, C., Athanasopoulos, T., Papagatsias, T., Herath, S., Benlahrech, A., Dickson, G., Meiser, A. & Patterson, S., 14 Aug 2019, (E-pub ahead of print) In: Journal of virology. p. 1-38 38 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2018

  A multicenter comparison of quantification methods for antisense oligonucleotide-induced DMD exon 51 skipping in Duchenne muscular dystrophy cell cultures

  Hiller, M., Falzarano, M. S., Garcia-Jimenez, I., Sardone, V., Verheul, R. C., Popplewell, L., Anthony, K., Ruiz-Del-Yerro, E., Osman, H., Goeman, J. J., Mamchaoui, K., Dickson, G., Ferlini, A., Muntoni, F., Aartsma-Rus, A., Arechavala-Gomeza, V., Datson, N. A. & Spitali, P., 2 Oct 2018, In: PLoS ONE. 13, 10, p. 1-15 15 p., e0204485.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Delta-Like 4 Activates Notch 3 to Regulate Self-Renewal in Skeletal Muscle Stem Cells

  Low, S. H., Barnes, J., Zammit, P. & Beauchamp, J., Mar 2018, In: Stem Cells. 36, 3, p. 458-466 9 p.

  Research output: Contribution to journal › Article › peer-review

• Early-Childhood Conduct Problems Predict Economic and Political Discontent in Adulthood: Evidence from Two Large, Longitudinal UK Cohorts

  Lewis, G., 1 May 2018, In: Psychological Science. 29, 5, p. 711-722 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  262 Downloads (Pure)

• Editorial of the Special Issue: Antisense Therapies

  Popplewell, L. J., 27 Sept 2018, In: Biomedicines. 6, 4, p. 1-2 2 p., 95.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Face Identity Recognition and the Social Difficulties Component of the Autism-Like Phenotype: Evidence for Phenotypic and Genetic Links

  Lewis, G., Aug 2018, In: Journal of Autism and Developmental Disorders. 48, 8, p. 2758–2765 8 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• High-efficiency transduction of spinal cord motor neurons by intrauterine delivery of integration-deficient lentiviral vectors

  Ahmed, S. G., Waddington, S. N., Boza-Morán, M. G. & Yáñez-Muñoz, R. J., 10 Mar 2018, In: Journal of Controlled Release. 273, p. 99-107 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Higher levels of childhood intelligence predict increased support for economic conservatism in adulthood

  Lewis, G. & Bates, T., Sept 2018, In: Intelligence. 70, p. 36-41 6 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  78 Downloads (Pure)

• Identity uncertainty and UK–Scottish relations: Different dynamics depending on relative identity centrality

  Jung, J., Hogg, M. & Lewis, G., 1 Sept 2018, In: Group Processes and Intergroup Relations. 21, 6, p. 861-873 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  201 Downloads (Pure)

• Molecular Evidence of Genome Editing in a Mouse Model of Immunodeficiency

  Abdul-Razak, H. H., Rocca, C. J., Howe, S. J., Alonso-Ferrero, M. E., Wang, J., Gabriel, R., Bartholomae, C. C., Gan, C. H. V., Garín, M. I., Roberts, A., Blundell, M. P., Prakash, V., Molina-Estevez, F. J., Pantoglou, J., Guenechea, G., Holmes, M. C., Gregory, P. D., Kinnon, C., Von Kalle, C., Schmidt, M., & 3 othersBueren, J. A., Thrasher, A. J. & Yáñez-Muñoz, R. J., 29 May 2018, In: Scientific Reports. 8, p. 1-13 13 p., 8214.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Perampanel and decanoic acid show synergistic action against AMPA receptors and seizures

  Augustin, K., Williams, S., Cunningham, M., Anita, D., Friedrich, M., Jayasekera, A., Hussain, M., Holliman, D., Mitchell, P., Jenkins, A., Chen, P., Walker, M. & Williams, R., Nov 2018, In: Epilepsia. 59, 11, p. e172-e178 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Recognition of facial expression and identity in part reflects a common ability, independent of general intelligence and visual short-term memory

  Connolly, H., Young, A. & Lewis, G., 18 Oct 2018, (E-pub ahead of print) In: Cognition and Emotion. p. 1-10 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  47 Downloads (Pure)

• Reversible immortalisation enables genetic correction of human muscle progenitors and engineering of next-generation human artificial chromosomes for Duchenne muscular dystrophy

  Benedetti, S., Uno, N., Hoshiya, H., Ragazzi, M., Ferrari, G., Kazuki, Y., Moyle, L. A., Tonlorenzi, R., Lombardo, A., Chaouch, S., Mouly, V., Moore, M., Popplewell, L., Kazuki, K., Katoh, M., Naldini, L., Dickson, G., Messina, G., Oshimura, M., Cossu, G., & 1 othersTedesco, F. S., 1 Feb 2018, In: EMBO Reports. 10, 2, p. 254-275 22 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Subclonal mutation selection in mouse lymphomagenesis identifies known cancer loci and suggests novel candidates

  Webster, P., Dawes, J., Dewchand, H., Takacs, K., Iadarola, B., Bolt, B., Caceres Silva, J., Kaczor, J., Dharmalingam, G., Dore, M., Game, L., Adejumo, T., Elliott, J., Naresh, K., Karimi, M., Rekopoulou, K., Tan, G., Paccanaro, A. & Uren, A., 9 Jul 2018, In: Nature Communications. 9, p. 1-14 14 p., 2649.

  Research output: Contribution to journal › Article › peer-review

  Open Access

• Widespread associations between trait conscientiousness and thickness of brain cortical regions

  Lewis, G., Dickie, D. A., Cox, S., Karama, S., Evans, A., Starr, J., Bastin, M., Wardlaw, J. & Deary, I., 1 Aug 2018, In: NeuroImage. 176, p. 22-28 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access
• 2017

  Chimeric Trojan Protein Insertion in Lentiviral Membranes Makes Lentiviruses Susceptible to Neutralization by Anti-Tetanus Serum Antibodies

  Le-Heron, A., Patterson, S., Yáñez-Muñoz, R. J. & Dickson, G., 2017, In: Human Gene Therapy. 28, 3, p. 242-254 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  57 Downloads (Pure)

• Dysfunctional transcripts are formed by alternative polyadenylation in OPMD

  Raz, V., Dickson, J. & 't Hoen, P. A. C., 5 Sept 2017, In: Oncotarget. 8, 43, p. 73516-73528 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  51 Downloads (Pure)

• Externalizing problems in childhood and adolescence predict subsequent educational achievement but for different genetic and environmental reasons

  Lewis, G., Asbury, K. & Plomin, R., Mar 2017, In: Journal of Child Psychology and Psychiatry. 58, 3, p. 292–304 13 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  File
  87 Downloads (Pure)