Centre of Gene and Cell Therapy

Projects

Projects per year 2009 2011 2012 2013 2014 2015 2016 2017 2024

• 1 Active
• 48 Finished

Projects per year

Search results

• Active

  Development of CRISPR/Cas Genome Editing as a Treatment for Ataxia Telangiectasia

  Yáñez-Muñoz, R. J.

  Action for AT

  1/11/17 → 11/03/24

  Project: Research

• Finished

  Establishing a mouse model of disease to test combined antisense oligonucleotides and AAV systemic gene therapy as new treatment for Oculopharyngeal muscular dystrophy

  Malerba, A.

  AFM Telethon

  1/09/21 → 31/08/22

  Project: Research

• Identifying metabolic signatures of pathology in muscle and blood to identify biomarkers of oculopharyngeal muscular dystrophy.

  Snowden, S. & Popplewell, L.

  AFM Telethon

  1/09/21 → 31/08/22

  Project: Research

• Plants and Minerals in Byzantine Popular Pharmacy. A New Multidisciplinary Approach

  Zipser, B. & Scott, A. C.

  Wellcome Trust

  1/11/19 → 31/10/22

  Project: Other

• ABI innovation: A Graph based Approach for the Genome Wide Prediction of Conditionally Essential Genes

  Paccanaro, A.

  National Science Foundation (NSF), National Science Foundation

  15/09/17 → 14/09/20

  Project: Research

• In vivo evaluation of muscle specific synthetic promoters

  Dickson, G.

  SynPromics Ltd

  1/08/17 → 30/04/18

  Project: Research

• Universal Microdystrophin (MD) Gene Therapy Clinical Trial for DMD (UNITE-DMD)

  Dickson, G., Popplewell, L. & Malerba, A.

  Muscular Dystrophy UK

  1/07/17 → 30/06/21

  Project: Other

• Enhancement of antisense oligonucleotide-mediated exon skipping as a therapy for Duchenne muscular dystrophy

  Popplewell, L.

  UCB Biopharma SPRL

  6/02/17 → 5/02/20

  Project: Research

• Genome Editing in Muscle Stem Cells for Duchenne Muscular Dystrophy

  Dickson, G.

  Rosetrees Trust

  1/02/17 → 31/01/18

  Project: Other

• Development of cell-penetrating peptide-conjugated antisense oligonucleotides for the treatment of fascioscapulohumeral muscular dystrophy

  Popplewell, L. & Dickson, G.

  1/10/16 → 30/09/19

  Project: Other

• In vivo activity assessment of four AAV OPMD clinical constructs – PhasesI&II

  Dickson, G.

  Benitec Ltd

  1/09/16 → 31/07/17

  Project: Other

• Development of genome editing surgery with applicability to all DMD patients

  Popplewell, L.

  1/07/16 → 31/12/16

  Project: Research

• Prediction of drug cocktails with anti-trypanosomal effect

  Paccanaro, A.

  Eng & Phys Sci Res Council EPSRC

  1/06/16 → 31/03/17

  Project: Research

• An investigation into the role of Rp131 and regulation of ribosome biogenesis in the pathogenesis of Duchenne muscular dystrophy implications for novel therapeutic strategies

  Popplewell, L.

  Neurological Foundation of New Zealand - Philip Wrightson Fellowship

  1/04/16 → 31/03/18

  Project: Other

• The UK Spinal Muscular Atrophy Research Consortium

  Yáñez-Muñoz, R. J.

  The SMA Trust

  1/01/16 → 3/03/20

  Project: Research

• Enhancement of splicing efficiency between trans-spliced DMD AAV vectors for the production of full-length fully functional dystrophin protein

  Dickson, G.

  1/01/16 → 1/01/17

  Project: Research

• Development of broadly applicable combinatorial genome editing and antisense therapies for Duchenne muscular dystrophy addressing dystrophin deficiency, muscle wasting and muscle fibrosis

  Popplewell, L.

  Muscular Dystrophy UK

  1/10/15 → 30/09/16

  Project: Research

• Inducing Immune-Tolerance to AAV Vector Capsid for Gene Therapy of Duchenne Muscular Dystrophy

  Dickson, G.

  Jesse's Journey

  1/10/15 → 31/08/20

  Project: Research

• Second generation hyper-active micro-dystrophin AAV vectors for Duchenne muscular dystrophy gene therapy

  Dickson, G.

  Muscular Dystrophy Campaign

  1/10/15 → 30/09/18

  Project: Research

• Stage 2 study on DNA-directed RNAi for the treatment of OPMd

  Dickson, G.

  Benitec Ltd

  1/09/15 → 31/08/16

  Project: Research

• Bilateral NSF/BIO-BBSRC - Translational landscape to link cell growth with proliferation in the root meristem

  Bogre, L. & Paccanaro, A.

  Biotechnology&BioSci Research BBSRC

  1/07/15 → 30/06/18

  Project: Research

• Development of dual/triple RNA and protein transpliced AAV vectors to restore quasi/full length co-dystrophin variants to muscle

  Dickson, G.

  Association Francais contre les Myopathies

  10/02/15 → 9/02/16

  Project: Research

• Research Programme towards a Phase 1 / 2 Clinical trial of Microdystrophin Gene Therapy

  Dickson, G.

  Join our Boys

  11/11/14 → 10/03/16

  Project: Research

• Development of antisense oligonucleotide drugs to supress expression of the DUX4 protein as a therapy for fascioscapulohumeral muscular dystrophy (FSHD)

  Dickson, G.

  1/08/14 → 31/07/18

  Project: Research

• Enhancement of splicing efficiency between trans-spliced DMD AAV vectors for the production of full-length fully functional dystrophin protein

  Dickson, G.

  Action Duchenne

  1/07/14 → 30/06/15

  Project: Research

• Towards a clinical trial for Oculopharyngeal Muscular Dystrophy (OPMD)

  Dickson, G.

  Association Francais contre les Myopathies

  1/07/14 → 30/06/19

  Project: Research

• Multi-level analysis of the evolution of cooperative behaviour in social insects Marie Curie Fellow – Dr Fabio Manfredini

  Brown, M. J. F. & Paccanaro, A.

  European Union

  1/04/14 → 31/03/16

  Project: Research

• Permanent reading frame correction of mutated DMD gene using single-stranded DNA homologous recombination strategies

  Dickson, G.

  Duchenne Parent Project

  1/02/14 → 31/01/16

  Project: Research

• Optimization of micro-dystrophin gene therapy for Duchenne muscular dystrophy (MD-AAV)

  Dickson, G.

  Genethon

  6/01/14 → 5/01/16

  Project: Research

• Destructive Exon Skipping of Myostatin mRNA with and without Open Reading Frame Rescue of Dystrophin

  Dickson, G.

  1/01/14 → 30/06/15

  Project: Research

• Correction of Duchenne Muscular Dystrophy Mutations using Endonuclease-Mediated Genome Surgery

  Dickson, G.

  Muscular Dystrophy Campaign

  1/10/13 → 30/09/14

  Project: Research

• Vectorisation of Chondroitinase for therapy in spinal cord injury

  Yáñez-Muñoz, R. J.

  International Spinal Research Trust

  1/10/13 → 30/09/15

  Project: Research

• Development of dual/triple transpliced AAV vectors to restore quasi/full length dystrophin variants to muscle

  Dickson, G.

  Muscular Dystrophy Campaign

  1/10/13 → 30/09/16

  Project: Research

• MAPK signalling network to adapt leaf growth to drought conditions

  Bogre, L., Paccanaro, A. & Papdi, C.

  European Commission

  1/05/13 → 30/04/15

  Project: Research

• Gene Surgery for Duchenne Muscular Dystrophy(DMD)

  Dickson, G. & Yáñez-Muñoz, R. J.

  Association Francais contre les Myopathies

  1/04/13 → 31/03/15

  Project: Research

• Inference of RBR network and dynamic RBR complexes during leaf development

  Paccanaro, A., Bogre, L. & Horvath, B.

  European Commission

  1/03/13 → 28/02/15

  Project: Research

• Phase I/IIa clinical trial in Duchenne muscular dystrophy using systematically delivered morpholino antisense oligomer to skip exon 53.

  Dickson, G.

  European Union

  1/11/12 → 31/10/15

  Project: Research

• Development of an antisense oligonucleotide based strategy to manipulate RNA editing of AMPA receptor subunits in cell lines and motor neurones

  Chen, P.

  Motor Neurone Disease Association

  1/10/12 → 30/09/15

  Project: Research

• A GPU-based high performance system for discovering consensus domain architecture and functional annotation of protein families

  Paccanaro, A.

  Biotechnology&BioSci Research BBSRC

  1/07/12 → 30/09/13

  Project: Research

• Long-term follow-up of transgene expression in vivo in mouse motor neurons after intra-uterine injection

  Yáñez-Muñoz, R. J.

  The Spinal Muscular Atrophy Trust

  1/04/12 → 30/06/12

  Project: Research

• Combination Antisense Treatment for Duchenne Muscular Dystrophy: Open Reading Frame Rescue of Dystrophin in conjunction with Destructive Exon Skipping of Myostatin mRNA

  Dickson, G.

  1/02/12 → 30/03/14

  Project: Research

• DNA-Directed RNAi (ddRNAi) to inhibit expression of the gene product (PABPN1) involved in the aetiology of the inclusion body disease, Oculopharyngeal Muscular Dystrophy (OPMD)

  Dickson, G.

  Benitec Ltd

  1/01/12 → 30/06/13

  Project: Research

• Pathophysiology and therapeutic approaches in Oculoparyngeal Muscular Dystropy (OPMD)

  Dickson, G.

  Association Francais contre les Myopathies

  1/05/11 → 30/04/13

  Project: Research

• Advances in oligonucleotide-mediated exon skipping for DMD and related disorders

  Dickson, G.

  Association Francais contre les Myopathies

  1/04/11 → 31/03/15

  Project: Research

• UK HVC

  Dickson, G.

  Wellcome Trust

  1/02/11 → 31/01/13

  Project: Research

• Advanced antisense oligonucleotide technology for Exon skipping in Duchenne Muscular Dystrophy

  Dickson, G.

  Wellcome Trust

  1/02/11 → 31/01/14

  Project: Research

• Investigating potential interactions between glutamatergic signalling and dopamine receptor interacting proteins (DRIPs) in psychiatric disorders

  Chen, P.

  SouthWest London Academic Network

  1/10/10 → 30/09/13

  Project: Research

• Meganuclease-Enhance Genome Correction Therapy for Duchenne Muscular Dystrophy

  Dickson, G.

  Association Francais contre les Myopathies

  1/04/10 → 31/03/12

  Project: Research

• Integration-deficient lentiviral vectors delivering neurotrophic factors for gene therapy of Parkinson’s disease

  Lu-Nguyen, N., Broadstock, M. & Yáñez-Muñoz, R. J.

  1/10/09 → 1/07/13

  Project: Research