Centre of Gene and Cell Therapy

Projects

Projects per year 2009 2011 2012 2013 2014 2015 2016 2017 2025

• 49 Finished

Projects per year

Search results

• Finished

  Establishing a mouse model of disease to test combined antisense oligonucleotides and AAV systemic gene therapy as new treatment for Oculopharyngeal muscular dystrophy

  Malerba, A. (PI)

  AFM Telethon

  1/09/21 → 31/08/22

  Project: Research

• Identifying metabolic signatures of pathology in muscle and blood to identify biomarkers of oculopharyngeal muscular dystrophy.

  Snowden, S. (PI) & Popplewell, L. (CoI)

  AFM Telethon

  1/09/21 → 31/08/22

  Project: Research

• Plants and Minerals in Byzantine Popular Pharmacy. A New Multidisciplinary Approach

  Zipser, B. (PI) & Scott, A. C. (CoI)

  Wellcome Trust

  1/11/19 → 31/10/22

  Project: Research

• Development of CRISPR/Cas Genome Editing as a Treatment for Ataxia Telangiectasia

  Yáñez-Muñoz, R. J. (PI)

  Action for A-T

  1/11/17 → 11/03/25

  Project: Research

• ABI innovation: A Graph based Approach for the Genome Wide Prediction of Conditionally Essential Genes

  Paccanaro, A. (PI)

  National Science Foundation (NSF), National Science Foundation

  15/09/17 → 14/09/20

  Project: Research

• In vivo evaluation of muscle specific synthetic promoters

  Dickson, G. (PI)

  SynPromics Ltd

  1/08/17 → 30/04/18

  Project: Research

• Universal Microdystrophin (MD) Gene Therapy Clinical Trial for DMD (UNITE-DMD)

  Dickson, G. (PI), Popplewell, L. (CoI) & Malerba, A. (Researcher)

  Muscular Dystrophy UK

  1/07/17 → 30/06/21

  Project: Research

• Enhancement of antisense oligonucleotide-mediated exon skipping as a therapy for Duchenne muscular dystrophy

  Popplewell, L. (PI)

  UCB Biopharma SPRL

  6/02/17 → 5/02/20

  Project: Research

• Genome Editing in Muscle Stem Cells for Duchenne Muscular Dystrophy

  Dickson, G. (PI)

  Rosetrees Trust

  1/02/17 → 31/01/18

  Project: Research

• Development of cell-penetrating peptide-conjugated antisense oligonucleotides for the treatment of fascioscapulohumeral muscular dystrophy

  Popplewell, L. (PI) & Dickson, G. (CoI)

  1/10/16 → 30/09/19

  Project: Research

• In vivo activity assessment of four AAV OPMD clinical constructs – Phases I & II

  Dickson, G. (PI)

  Benitec Ltd

  1/09/16 → 31/07/17

  Project: Research

• Development of genome editing surgery with applicability to all DMD patients

  Popplewell, L. (PI)

  1/07/16 → 31/12/16

  Project: Research

• Prediction of drug cocktails with anti-trypanosomal effect

  Paccanaro, A. (PI)

  Eng & Phys Sci Res Council EPSRC

  1/06/16 → 31/03/17

  Project: Research

• An investigation into the role of Rp131 and regulation of ribosome biogenesis in the pathogenesis of Duchenne muscular dystrophy implications for novel therapeutic strategies

  Popplewell, L. (PI)

  Neurological Foundation of New Zealand

  1/04/16 → 31/03/18

  Project: Research

• The UK Spinal Muscular Atrophy Research Consortium

  Yáñez-Muñoz, R. J. (PI)

  The SMA Trust

  1/01/16 → 3/03/20

  Project: Research

• Enhancement of splicing efficiency between trans-spliced DMD AAV vectors for the production of full-length fully functional dystrophin protein

  Dickson, G. (PI)

  1/01/16 → 1/01/17

  Project: Research

• Development of broadly applicable combinatorial genome editing and antisense therapies for Duchenne muscular dystrophy addressing dystrophin deficiency, muscle wasting and muscle fibrosis

  Popplewell, L. (PI)

  Muscular Dystrophy UK

  1/10/15 → 30/09/16

  Project: Research

• Inducing Immune-Tolerance to AAV Vector Capsid for Gene Therapy of Duchenne Muscular Dystrophy

  Dickson, G. (PI)

  Jesse's Journey

  1/10/15 → 31/08/20

  Project: Research

• Second generation hyper-active micro-dystrophin AAV vectors for Duchenne muscular dystrophy gene therapy

  Dickson, G. (PI)

  Muscular Dystrophy Campaign

  1/10/15 → 30/09/18

  Project: Research

• Stage 2 study on DNA-directed RNAi for the treatment of OPMd

  Dickson, G. (PI)

  Benitec Ltd

  1/09/15 → 31/08/16

  Project: Research

• Bilateral NSF/BIO-BBSRC - Translational landscape to link cell growth with proliferation in the root meristem

  Bogre, L. (PI) & Paccanaro, A. (PI)

  Biotechnology and Biological Sciences Research Council BBSRC

  1/07/15 → 30/06/18

  Project: Research

• Development of dual/triple RNA and protein transpliced AAV vectors to restore quasi/full length co-dystrophin variants to muscle

  Dickson, G. (PI)

  Association Francais contre les Myopathies

  10/02/15 → 9/02/16

  Project: Research

• Research Programme towards a Phase 1 / 2 Clinical trial of Microdystrophin Gene Therapy

  Dickson, G. (PI)

  Join our Boys

  11/11/14 → 10/03/16

  Project: Research

• Development of antisense oligonucleotide drugs to supress expression of the DUX4 protein as a therapy for fascioscapulohumeral muscular dystrophy (FSHD)

  Dickson, G. (PI)

  1/08/14 → 31/07/18

  Project: Research

• Towards a clinical trial for Oculopharyngeal Muscular Dystrophy (OPMD)

  Dickson, G. (PI)

  Association Francais contre les Myopathies

  1/07/14 → 30/06/19

  Project: Research

• Enhancement of splicing efficiency between trans-spliced DMD AAV vectors for the production of full-length fully functional dystrophin protein

  Dickson, G. (PI)

  Action Duchenne

  1/07/14 → 30/06/15

  Project: Research

• Multi-level analysis of the evolution of cooperative behaviour in social insects Marie Curie Fellow – Dr Fabio Manfredini

  Brown, M. J. F. (PI) & Paccanaro, A. (CoI)

  European Union

  1/04/14 → 31/03/16

  Project: Research

• Permanent reading frame correction of mutated DMD gene using single-stranded DNA homologous recombination strategies

  Dickson, G. (PI)

  Duchenne Parent Project Netherlands

  1/02/14 → 31/01/16

  Project: Research

• Optimization of micro-dystrophin gene therapy for Duchenne muscular dystrophy (MD-AAV)

  Dickson, G. (PI)

  Genethon

  6/01/14 → 5/01/16

  Project: Research

• Destructive Exon Skipping of Myostatin mRNA with and without Open Reading Frame Rescue of Dystrophin

  Dickson, G. (PI)

  1/01/14 → 30/06/15

  Project: Research

• Development of dual/triple transpliced AAV vectors to restore quasi/full length dystrophin variants to muscle

  Dickson, G. (PI)

  Muscular Dystrophy Campaign

  1/10/13 → 30/09/16

  Project: Research

• Correction of Duchenne Muscular Dystrophy Mutations using Endonuclease-Mediated Genome Surgery

  Dickson, G. (PI)

  Muscular Dystrophy Campaign

  1/10/13 → 30/09/14

  Project: Research

• Vectorisation of Chondroitinase for therapy in spinal cord injury

  Yáñez-Muñoz, R. J. (PI)

  International Spinal Research Trust

  1/10/13 → 30/09/15

  Project: Research

• MAPK signalling network to adapt leaf growth to drought conditions

  Bogre, L. (PI), Paccanaro, A. (CoI) & Papdi, C. (CoI)

  European Commission

  1/05/13 → 30/04/15

  Project: Research

• Gene Surgery for Duchenne Muscular Dystrophy(DMD)

  Dickson, G. (PI) & Yáñez-Muñoz, R. J. (CoI)

  Association Francais contre les Myopathies

  1/04/13 → 31/03/15

  Project: Research

• Inference of RBR network and dynamic RBR complexes during leaf development

  Paccanaro, A. (PI), Bogre, L. (CoI) & Horvath, B. (CoI)

  European Commission

  1/03/13 → 28/02/15

  Project: Research

• Phase I/IIa clinical trial in Duchenne muscular dystrophy using systematically delivered morpholino antisense oligomer to skip exon 53.

  Dickson, G. (PI)

  European Union

  1/11/12 → 31/10/15

  Project: Research

• Development of an antisense oligonucleotide based strategy to manipulate RNA editing of AMPA receptor subunits in cell lines and motor neurones

  Chen, P. (PI)

  Motor Neurone Disease Association

  1/10/12 → 30/09/15

  Project: Research

• A GPU-based high performance system for discovering consensus domain architecture and functional annotation of protein families

  Paccanaro, A. (PI)

  Biotechnology and Biological Sciences Research Council BBSRC

  1/07/12 → 30/09/13

  Project: Research

• Long-term follow-up of transgene expression in vivo in mouse motor neurons after intra-uterine injection

  Yáñez-Muñoz, R. J. (PI)

  The Spinal Muscular Atrophy Trust

  1/04/12 → 30/06/12

  Project: Research

• Combination Antisense Treatment for Duchenne Muscular Dystrophy: Open Reading Frame Rescue of Dystrophin in conjunction with Destructive Exon Skipping of Myostatin mRNA

  Dickson, G. (PI)

  1/02/12 → 30/03/14

  Project: Research

• DNA-Directed RNAi (ddRNAi) to inhibit expression of the gene product (PABPN1) involved in the aetiology of the inclusion body disease, Oculopharyngeal Muscular Dystrophy (OPMD)

  Dickson, G. (PI)

  Benitec Ltd

  1/01/12 → 30/06/13

  Project: Research

• Pathophysiology and therapeutic approaches in Oculoparyngeal Muscular Dystropy (OPMD)

  Dickson, G. (PI)

  Association Francais contre les Myopathies

  1/05/11 → 30/04/13

  Project: Research

• Advances in oligonucleotide-mediated exon skipping for DMD and related disorders

  Dickson, G. (PI)

  Association Francais contre les Myopathies

  1/04/11 → 31/03/15

  Project: Research

• UK HVC

  Dickson, G. (PI)

  Wellcome Trust

  1/02/11 → 31/01/13

  Project: Research

• Advanced antisense oligonucleotide technology for Exon skipping in Duchenne Muscular Dystrophy

  Dickson, G. (PI)

  Wellcome Trust

  1/02/11 → 31/01/14

  Project: Research

• Investigating potential interactions between glutamatergic signalling and dopamine receptor interacting proteins (DRIPs) in psychiatric disorders

  Chen, P. (PI)

  SouthWest London Academic Network

  1/10/10 → 30/09/13

  Project: Research

• Meganuclease-Enhance Genome Correction Therapy for Duchenne Muscular Dystrophy

  Dickson, G. (PI)

  Association Francais contre les Myopathies

  1/04/10 → 31/03/12

  Project: Research

• Integration-deficient lentiviral vectors delivering neurotrophic factors for gene therapy of Parkinson’s disease

  Lu-Nguyen, N. (Student), Broadstock, M. (Fellow) & Yáñez-Muñoz, R. J. (PI)

  1/10/09 → 1/07/13

  Project: Research